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Stockholders' Equity - Additional Information (Details)
1 Months Ended 6 Months Ended
Dec. 05, 2019
USD ($)
Mar. 31, 2022
USD ($)
Dec. 31, 2019
USD ($)
Jun. 30, 2022
USD ($)
Vote
Days
$ / shares
shares
Dec. 31, 2021
$ / shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Common stock, voting right per share | Vote       1  
Weighted average grant date fair value | $ / shares       $ 23.70  
Unrecognized compensation cost related to non-vested stock options expected to be recognized       $ 90,300,000  
Expected vesting period for non-vested share-based compensation       3 years 1 month 6 days  
Non-vested options outstanding | shares       6,169  
Exercise price of warrants (in dollars per share) | $ / shares       $ 46.75 $ 80.43
Warrants | 2020 warrants          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Common stock to be issued if warrants are exercised (in shares) | shares       15,541  
Exercise price of warrants (in dollars per share) | $ / shares       $ 80.43  
Trading days | Days       10  
Term of warrants (in years)       7 years  
Fair value       $ 800,000  
Warrants | 2022 warrants          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Common stock to be issued if warrants are exercised (in shares) | shares       35,255  
Exercise price of warrants (in dollars per share) | $ / shares       $ 31.91  
Term of warrants (in years)       7 years  
Fair value       $ 900,000  
Restricted Stock Units          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Vesting period       4 years  
Compensation cost not yet recognized related to unvested RSUs       $ 19,200,000  
Weighted average contractual term       3 years 3 months 18 days  
2015 Plan          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Shares available for future grant | shares       3,341,813  
2019 Shelf Registration          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Proceeds from issuance of common stock, gross $ 292,900,000        
SVB Leerink | December 2019 Sales Agreement          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Common stock sales agreement, commission percentage     3.00%    
SVB Leerink | March 2022 Sales Agreement          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Common stock sales agreement, commission percentage   3.00%      
SVB Leerink | December 2019 and March 2022 Sales Agreement          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Proceeds from issuance of common stock, gross       $ 58,600,000  
Shares issued | shares       1,914,747  
Proceeds from issuance of common stock, net       $ 56,800,000  
Maximum | SVB Leerink | December 2019 Sales Agreement          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Common stock sales agreement, authorized amount     $ 80,000,000    
Maximum | SVB Leerink | March 2022 Sales Agreement          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Common stock sales agreement, authorized amount   $ 200,000,000      
Hercules Capital Inc          
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]          
Shares issued | shares       152,487  
Proceeds from issuance of common stock, net       $ 5,000,000.0  
Share Price | $ / shares       $ 32.79