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Stockholders' Equity (Tables)
6 Months Ended
Jun. 30, 2022
Equity [Abstract]  
Summary of Stock Option Activity

The following table sets forth the stock option activity for the six months ended June 30, 2022:

 

 

 

​Number
of shares

 

 

​Weighted
average
exercise price

 

 

Weighted
average
contractual
term

 

 

​Aggregate
intrinsic
value

 

Outstanding at December 31, 2021

 

 

5,090,377

 

 

$

28.89

 

 

 

 

 

 

 

Granted

 

 

1,590,426

 

 

 

31.62

 

 

 

 

 

 

 

Exercised

 

 

(24,706

)

 

 

14.49

 

 

 

 

 

 

 

Forfeited

 

 

(111,376

)

 

 

41.51

 

 

 

 

 

 

 

Expired

 

 

(22,160

)

 

 

46.50

 

 

 

 

 

 

 

Outstanding at June 30, 2022

 

 

6,522,561

 

 

$

28.98

 

 

 

7.5

 

 

$

95,081,479

 

Vested and expected to vest at June 30, 2022

 

 

6,522,561

 

 

$

28.98

 

 

 

7.5

 

 

$

95,081,479

 

Exercisable at June 30, 2022

 

 

3,170,564

 

 

$

17.70

 

 

 

5.8

 

 

$

76,800,643

 

Schedule of RSU Activity

The following table sets forth the RSU activity for the six months ended June 30, 2022:

 

 

Number
of shares

 

 

Weighted
average
grant date
fair value

 

Outstanding at December 31, 2021

 

 

302,764

 

 

$

42.93

 

Granted

 

 

482,793

 

 

 

23.85

 

Vested

 

 

(63,330

)

 

 

42.19

 

Forfeited

 

 

(8,916

)

 

 

40.51

 

Outstanding at June 30, 2022

 

 

713,311

 

 

$

30.12

 

Schedule of Stock-Based Compensation Expense Recognized

Stock-based compensation expense recognized for the three and six months ended June 30, 2022 and 2021 was allocated as follows:

 

 

Three Months Ended June 30,

 

 

Six Months Ended June 30,

 

 

2022

 

 

2021

 

 

2022

 

 

2021

 

Research and development

 

$

2,679,848

 

 

$

2,302,504

 

 

$

4,489,325

 

 

$

3,836,899

 

General and administrative

 

 

7,481,830

 

 

 

3,153,738

 

 

 

13,270,682

 

 

 

5,350,440

 

Total

 

$

10,161,678

 

 

$

5,456,242

 

 

$

17,760,007

 

 

$

9,187,339

 

Schedule of Warrant Activity

The following table summarizes warrant activity for the six months ended June 30, 2022:

 

 

 

 

 

 

Weighted

 

 

 

 

 

 

average

 

 

 

Warrants

 

 

exercise price

 

Outstanding at December 31, 2021

 

 

15,541

 

 

$

80.43

 

Issued

 

 

35,255

 

 

 

31.91

 

Exercised

 

 

 

 

 

 

Outstanding at June 30, 2022

 

 

50,796

 

 

$

46.75