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Stockholders' Equity - Additional Information (Details)
1 Months Ended 3 Months Ended
Dec. 05, 2019
USD ($)
Dec. 31, 2019
USD ($)
Mar. 31, 2022
USD ($)
Vote
d
$ / shares
shares
Dec. 31, 2021
$ / shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Common stock, voting right per share | Vote     1  
Weighted average grant date fair value | $ / shares     $ 21.00  
Unrecognized compensation cost related to non-vested stock options expected to be recognized     $ 91,000,000.0  
Expected vesting period for non-vested share-based compensation     3 years 3 months 18 days  
Non-vested options outstanding | shares     6,169  
Exercise price of warrants (in dollars per share) | $ / shares     $ 80.43 $ 80.43
Warrants | Term loan 2020 tranche one        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Common stock to be issued if warrants are exercised (in shares) | shares     15,541  
Exercise price of warrants (in dollars per share) | $ / shares     $ 80.43  
Trading days | d     10  
Term of warrants (in years)     7 years  
Fair value     $ 900,000  
Restricted Stock Units        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Vesting period     4 years  
Compensation cost not yet recognized related to unvested RSUs     $ 19,500,000  
Weighted average contractual term     3 years 7 months 6 days  
2015 Plan        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Shares available for future grant | shares     2,187,058  
2019 Shelf Registration        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Proceeds from issuance of common stock, gross $ 261,200,000      
SVB Leerink | December 2019 Sales Agreement        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Common stock sales agreement, commission percentage   3.00%    
SVB Leerink | March 2022 Sales Agreement        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Common stock sales agreement, commission percentage     3.00%  
SVB Leerink | December 2019 and March 2022 Sales Agreement        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Proceeds from issuance of common stock, gross     $ 32,000,000.0  
Shares issued | shares     1,044,081  
Proceeds from issuance of common stock, net     $ 31,000,000.0  
Maximum | SVB Leerink | December 2019 Sales Agreement        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Common stock sales agreement, authorized amount   $ 80,000,000    
Maximum | SVB Leerink | March 2022 Sales Agreement        
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Common stock sales agreement, authorized amount     $ 200,000,000