Consolidated Statements of Stockholders' Equity - USD ($)	Total	License Agreement	Common Stock	Common Stock License Agreement	Additional Paid-in Capital	Additional Paid-in Capital License Agreement	Accumulated Deficit
Beginning balance at Dec. 31, 2018	$ 937,921		$ 3,009		$ 108,485,219		$ (107,550,307)
Balance (in shares) at Dec. 31, 2018			30,087,213
Stock-based compensation	6,115,160				6,115,160
Issuance of common stock upon exercise of options	1,143,841		$ 25		1,143,816
Issuance of common stock upon exercise of options (in shares)			252,773
Exercise of warrants	249,836		$ 10		249,826
Exercise of warrants (in shares)			97,541
Issuance of warrants upon debt financing	387,000				387,000
Issuance of common stock upon financing	238,233,817		$ 649		238,233,168
Issuance of common stock upon financing (in shares)			6,495,690
Net loss	(68,345,186)						(68,345,186)
Ending balance at Dec. 31, 2019	178,722,389		$ 3,693		354,614,189		(175,895,493)
Balance (in shares) at Dec. 31, 2019			36,933,217
Stock-based compensation	14,756,206				14,756,206
Issuance of common stock upon exercise of options	1,049,849		$ 13		1,049,836
Issuance of common stock upon exercise of options (in shares)			127,778
Exercise of warrants	6		$ 6
Exercise of warrants (in shares)			63,831
Issuance of warrants upon debt financing	884,216				884,216
Issuance of common stock upon financing	14,125,506	$ 7,155,337	$ 17	$ 8	14,125,489	$ 7,155,329
Issuance of common stock upon financing (in shares)			167,243	82,019
Net loss	(102,900,600)						(102,900,600)
Ending balance at Dec. 31, 2020	$ 113,792,909		$ 3,737		392,585,265		(278,796,093)
Balance (in shares) at Dec. 31, 2020	37,374,088		37,374,088
Stock-based compensation	$ 20,801,380				20,801,380
Issuance of common stock upon exercise of options	$ 4,402,400		$ 33		4,402,367
Issuance of common stock upon exercise of options (in shares)	326,219		326,219
Issuance of common stock upon vesting of RSUs	$ 1		$ 1
Issuance of common stock upon vesting of RSUs (in shares)			6,191
Issuance of common stock upon financing	7,212,367		$ 11		7,212,356
Issuance of common stock upon financing (in shares)			110,296
Shares tendered for withholding taxes	(175,713)				(175,713)
Net loss	(130,402,992)						(130,402,992)
Ending balance at Dec. 31, 2021	$ 15,630,352		$ 3,782		$ 424,825,655		$ (409,199,085)
Balance (in shares) at Dec. 31, 2021	37,816,794		37,816,794