X0306 4 2018-06-07 0 0001581720 Loxo Oncology, Inc. LOXO 0001579310 Flaherty Keith T. C/O LOXO ONCOLOGY, INC. 281 TRESSER BLVD, 9TH FLOOR STAMFORD CT 06901 1 0 0 0 Common Stock 2018-06-07 4 M 0 50000 1.184 A 59732 D Common Stock 2018-06-07 4 S 0 1900 169.8458 D 57832 D Common Stock 2018-06-07 4 S 0 5021 171.1530 D 52811 D Common Stock 2018-06-07 4 S 0 4634 172.0348 D 48177 D Common Stock 2018-06-07 4 S 0 12243 173.3220 D 35934 D Common Stock 2018-06-07 4 S 0 16037 174.0446 D 19897 D Common Stock 2018-06-07 4 S 0 4743 175.1004 D 15154 D Common Stock 2018-06-07 4 S 0 5422 175.9712 D 9732 D Director Stock Option (right to buy) 1.184 2018-06-07 4 M 0 50000 0 D 2023-12-16 Common Stock 50000 32345 D Represents the aggregate of sales effected on the same day at different prices. Represents the weighted average sales price per share. The shares sold at prices ranging from $169.44 to $170.11 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $170.55 to $171.48 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $171.57 to $172.56 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $172.60 to $173.585 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $173.60 to $174.545 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $174.61 to $175.595 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $175.63 to $176.59 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. The stock option is immediately exercisable in full. /s/ Jennifer Burstein, by power of attorney 2018-06-11