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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001578850</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001070081</issuerCik>
      <issuerName>PTC THERAPEUTICS, INC.</issuerName>
      <secFileNumber>001-35969</secFileNumber>
      <issuerAddress>
        <com:street1>500 WARREN CORPORATE CENTER DRIVE</com:street1>
        <com:city>WARREN</com:city>
        <com:stateOrCountry>NJ</com:stateOrCountry>
        <com:zipCode>07059</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>9082227000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Almstead Neil Gregory</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2464</noOfUnitsSold>
      <aggregateMarketValue>222368.23</aggregateMarketValue>
      <noOfUnitsOutstanding>82949338</noOfUnitsOutstanding>
      <approxSaleDate>07/09/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/09/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2464</amountOfSecuritiesAcquired>
      <paymentDate>07/09/2026</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Neil G. Almstead</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/22/2026</saleDate>
      <amountOfSecuritiesSold>23749</amountOfSecuritiesSold>
      <grossProceeds>1921431.84</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Neil G. Almstead</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/24/2026</saleDate>
      <amountOfSecuritiesSold>5323</amountOfSecuritiesSold>
      <grossProceeds>452591.41</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Neil G. Almstead</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/25/2026</saleDate>
      <amountOfSecuritiesSold>20960</amountOfSecuritiesSold>
      <grossProceeds>1801869.07</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Neil G. Almstead</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/26/2026</saleDate>
      <amountOfSecuritiesSold>8130</amountOfSecuritiesSold>
      <grossProceeds>693145.82</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Neil G. Almstead</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/06/2026</saleDate>
      <amountOfSecuritiesSold>22161</amountOfSecuritiesSold>
      <grossProceeds>1905798.18</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Neil G. Almstead</name>
        <address>
          <com:street1>500 Warren Corporate Center Drive</com:street1>
          <com:city>Warren</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07059</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/07/2026</saleDate>
      <amountOfSecuritiesSold>24613</amountOfSecuritiesSold>
      <grossProceeds>2187694.51</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>07/09/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>11/11/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Neil G. Almstead</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
