X0306 4 2017-02-08 0 0001590750 SIGNAL GENETICS, INC. SGNL 0001578768 Gonyer David A C/O SIGNAL GENETICS, INC. 5740 FLEET STREET CARLSBAD CA 92008 1 0 0 0 Common Stock 2017-02-08 4 M 0 1200 7.65 A 1899 D Stock Option (Right to Buy) 7.65 2017-02-08 4 M 0 1200 0.00 D 2026-06-15 Common Stock 1200 0 D On November 4, 2016, the issuer effected a one-for-15 reverse split of its Common Stock (the "Reverse Split"), and the number of securities and/or the exercise price reported reflect the Reverse Split. The option initially vested and became exercisable in twelve equal monthly installments beginning on June 30, 2016 and ending on May 31, 2017. However, upon approval of the issuer's board of directors, vesting was accelerated and the option became fully vested. /s/ Samuel D. Riccitelli, Attorney-in-Fact for David A. Gonyer 2017-02-08