144 0001790214 XXXXXXXX LIVE 0001576885 Acumen Pharmaceuticals, Inc. 001-40551 427 PARK ST. CHARLOTTESVILLE VA 22902 925-368-8508 Zuga Matt Officer Common Stock Merrill Lynch

225 Liberty St Floor 37 New York NY 10281

4364 6986.22 60079778 01/21/2025 NASDAQ Common Stock 01/17/2025 Vesting of restricted stock unit award Acumen Pharmaceuticals, Inc. N 4364 01/17/2025 Granted as part of issuer equity compensation plan N Matt Zuga

427 PARK ST. CHARLOTTESVILLE VA 22902

Common Stock 01/03/2025 13235 24366.39 01/21/2025 08/30/2024 Matt Zuga