X0306 4 2023-01-04 0 0001576885 Acumen Pharmaceuticals, Inc. ABOS 0001706400 Porter Derrell C/O ACUMEN PHARMACEUTICALS, INC. 427 PARK ST., CHARLOTTESVILLE VA 22902 1 0 0 0 Stock Option Grant (right to buy) 5.46 2023-01-04 4 A 0 50000 0.00 A 2033-01-04 Common Stock 50000 50000 D The shares subject to the option will vest in equal monthly installments over a three year period such that the option is fully vested on the third anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date and shall vest and become immediately exercisable prior to the effectiveness of a change in control. /s/ Derrell Porter 2023-01-04