144 0001753159 XXXXXXXX LIVE 0001576280 Guardant Health, Inc. 001-38683 3100 HANOVER STREET PALO ALTO CA 94304 855-698-8887 Talasaz AmirAli Officer Common Stock Stifel Nicolaus & Company Inc

501 N Broadway St. Louis MO 63102

260000 26083200.00 132599929 05/12/2026 Nasdaq Common Stock 11/23/2021 Open Market Purchase Open Market N 50565 11/23/2021 Cash Common Stock 06/30/2024 Restricted Stock Units Issuer N 5653 06/30/2024 Equity Compensation Common Stock 03/13/2023 Open Market Purchase Open Market N 40000 03/13/2023 Cash Common Stock 03/14/2023 Open Market Purchase Open Market N 8500 03/14/2023 Cash Common Stock 09/30/2024 Restricted Stock Units Issuer N 5652 09/30/2024 Equity Compensation Common Stock 03/31/2024 Restricted Stock Units Issuer N 6952 03/31/2024 Equity Compensation Common Stock 12/23/2020 Stock Options Issuer N 23923 12/23/2020 Equity Compensation Common Stock 08/17/2021 Stock Options Issuer N 23293 08/17/2021 Equity Compensation Common Stock 08/24/2021 Stock Options Issuer N 630 08/24/2021 Equity Compensation Common Stock 09/22/2018 Founder Shares Issuer N 100000 09/22/2018 Founder Shares Y Shares were sold out of Talasaz & Eskandari 2017 Family Trust 05/12/2026 12/05/2025 /s/ Brian Schneiweiss, as a duly authorized representative of STIFEL, as attorney-in-fact for AmirAli Talasaz