<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001214130</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001576280</issuerCik>
      <issuerName>Guardant Health, Inc.</issuerName>
      <secFileNumber>001-38683</secFileNumber>
      <issuerAddress>
        <com:street1>3100 HANOVER STREET</com:street1>
        <com:city>PALO ALTO</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94304</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>855-698-8887</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>POTTER MYRTLE S</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Charles Schwab &amp; Co., Inc.</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>26</noOfUnitsSold>
      <aggregateMarketValue>1534.52</aggregateMarketValue>
      <noOfUnitsOutstanding>124705857</noOfUnitsOutstanding>
      <approxSaleDate>08/19/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>08/15/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Lapse</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Guardant Health, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>26</amountOfSecuritiesAcquired>
      <paymentDate>08/15/2025</paymentDate>
      <natureOfPayment>Equity Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>MYRTLE S POTTER</name>
        <address>
          <com:street1>3100 HANOVER STREET</com:street1>
          <com:city>PALO ALTO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94303</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Guardant Health, Inc.</securitiesClassTitle>
      <saleDate>06/16/2025</saleDate>
      <amountOfSecuritiesSold>2626</amountOfSecuritiesSold>
      <grossProceeds>130512.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>MYRTLE S POTTER</name>
        <address>
          <com:street1>3100 HANOVER STREET</com:street1>
          <com:city>PALO ALTO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94303</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Guardant Health, Inc.</securitiesClassTitle>
      <saleDate>06/18/2025</saleDate>
      <amountOfSecuritiesSold>26</amountOfSecuritiesSold>
      <grossProceeds>1286.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>MYRTLE S POTTER</name>
        <address>
          <com:street1>3100 HANOVER STREET</com:street1>
          <com:city>PALO ALTO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94303</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Guardant Health, Inc.</securitiesClassTitle>
      <saleDate>07/17/2025</saleDate>
      <amountOfSecuritiesSold>26</amountOfSecuritiesSold>
      <grossProceeds>1253.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>08/19/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>03/15/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>MYRTLE S POTTER</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
