Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023
OPERATING ACTIVITIES:
Net loss	$ (325,367)	$ (292,406)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	31,933	32,013
Operating lease costs	23,357	22,146
Stock-based compensation	104,045	66,439
Amortization of debt issuance costs	1,935	1,931
Amortization of discount on marketable debt securities	(2,815)	(10,913)
Unrealized and realized losses (gains) on marketable equity securities	47,225	(84,513)
Impairment of non-marketable equity securities and other related assets	0	29,054
Other	2,372	334
Cash effect of changes in operating assets and liabilities:
Accounts receivable, net	316	8,360
Inventory, net	(10,349)	(25,435)
Prepaid expenses and other current assets, net	(9,192)	(2,558)
Other assets, net	(1,561)	2,280
Accounts payable and accrued liabilities	(19,813)	26,577
Operating lease liabilities	(27,029)	(22,724)
Deferred revenue	9,598	3,168
Net cash used in operating activities	(175,345)	(246,247)
INVESTING ACTIVITIES:
Purchases of marketable debt securities	(307,323)	(629,902)
Maturities of marketable debt securities	35,000	828,700
Sales of marketable equity securities	19,195	0
Purchases of non-marketable equity securities and other related assets	(2,500)	(5,593)
Purchases of property and equipment	(16,210)	(16,409)
Net cash (used in) provided by investing activities	(271,838)	176,796
FINANCING ACTIVITIES:
Proceeds from issuance of common stock upon exercise of stock options	2,597	290
Proceeds from issuances of common stock under employee stock purchase plan	7,212	6,697
Taxes paid related to net share settlement of restricted stock units	(7,658)	(8,112)
Proceeds from follow-on public offering	0	402,500
Payment of offering costs related to follow-on public offering	0	(20,478)
Other	(212)	5,910
Net cash provided by financing activities	1,939	386,807
Net effect of foreign exchange rate changes on cash, cash equivalents and restricted cash	(75)	(1,941)
Net (decrease) increase in cash, cash equivalents and restricted cash	(445,319)	315,415
Cash, cash equivalents and restricted cash—Beginning of period	1,133,687	141,948
Cash, cash equivalents and restricted cash—End of period	688,368	457,363
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	585,022	457,339
Restricted cash – included in cash, cash equivalents and restricted cash	103,346	24
Total cash, cash equivalents and restricted cash	$ 688,368	$ 457,363