Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
OPERATING ACTIVITIES:
Net loss	$ (217,613)	$ (206,304)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	21,335	20,976
Operating lease costs	15,226	14,708
Stock-based compensation	54,276	44,620
Amortization of debt issuance costs	1,290	1,287
Amortization of premium (discount) on marketable debt securities	107	(3,085)
Unrealized losses (gains) on marketable equity securities	45,539	(67,879)
Impairment of non-marketable equity securities and other related assets	0	29,054
Other	1,385	108
Cash effect of changes in operating assets and liabilities:
Accounts receivable, net	(11,737)	10,695
Inventory, net	(5,035)	(8,931)
Prepaid expenses and other current assets, net	(8,661)	(891)
Other assets, net	(130)	1,700
Accounts payable and accrued liabilities	(15,025)	16,512
Operating lease liabilities	(17,696)	(14,970)
Deferred revenue	12,453	(6,056)
Net cash used in operating activities	(124,286)	(168,456)
INVESTING ACTIVITIES:
Purchase of marketable debt securities	0	(561,339)
Maturity of marketable debt securities	35,000	492,700
Purchase of non-marketable equity securities and other related assets	0	(1,227)
Purchase of property and equipment	(12,011)	(14,037)
Net cash provided by (used in) investing activities	22,989	(83,903)
FINANCING ACTIVITIES:
Proceeds from issuance of common stock upon exercise of stock options	2,577	220
Proceeds from issuances of common stock under employee stock purchase plan	7,212	6,697
Taxes paid related to net share settlement of restricted stock units	(4,784)	(5,109)
Proceeds from follow-on public offering	0	402,500
Payment of offering costs related to follow-on public offering	0	(21,271)
Other	(181)	(37)
Net cash provided by financing activities	4,824	383,000
Net effect of foreign exchange rate changes on cash, cash equivalents and restricted cash	(1,975)	(1,415)
Net (decrease) increase in cash, cash equivalents and restricted cash	(98,448)	129,226
Cash, cash equivalents and restricted cash—Beginning of period	1,133,687	141,948
Cash, cash equivalents and restricted cash—End of period	1,035,239	271,174
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	933,694	271,073
Restricted cash – included in cash, cash equivalents and restricted cash	101,545	101
Total cash, cash equivalents and restricted cash	$ 1,035,239	$ 271,174