Condensed Consolidated Statements of Stockholders’ Equity (Deficit) (unaudited) - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2022		102,619,383
Beginning balance at Dec. 31, 2022	$ 60,180	$ 1	$ 1,742,114	$ (19,522)	$ (1,662,413)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon follow-on public offering, net of offering costs (in shares)		14,375,000
Issuance of common stock in public offering, net of offering costs of $21,131	381,369		381,369
Issuance of common stock upon exercise of stock options (in shares)		31,879
Issuance of common stock upon exercise of stock options	220		220
Vesting of restricted stock units (in shares)		337,091
Common stock issued under employee stock purchase plan (in shares)		298,781
Common stock issued under employee stock purchase plan	6,697		6,697
Taxes paid related to net share settlement of restricted stock units	(5,109)		(5,109)
Stock-based compensation	44,620		44,620
Other comprehensive income (loss)	11,053			11,053
Net loss	(206,304)				(206,304)
Ending balance (in shares) at Jun. 30, 2023		117,662,134
Ending balance at Jun. 30, 2023	292,726	$ 1	2,169,911	(8,469)	(1,868,717)
Beginning balance (in shares) at Mar. 31, 2023		102,708,305
Beginning balance at Mar. 31, 2023	(44,551)	$ 1	1,763,544	(12,150)	(1,795,946)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon follow-on public offering, net of offering costs (in shares)		14,375,000
Issuance of common stock in public offering, net of offering costs of $21,131	381,369		381,369
Issuance of common stock upon exercise of stock options (in shares)		10,830
Issuance of common stock upon exercise of stock options	63		63
Vesting of restricted stock units (in shares)		269,218
Common stock issued under employee stock purchase plan (in shares)		298,781
Common stock issued under employee stock purchase plan	6,697		6,697
Taxes paid related to net share settlement of restricted stock units	(4,116)		(4,116)
Stock-based compensation	22,354		22,354
Other comprehensive income (loss)	3,681			3,681
Net loss	(72,771)				(72,771)
Ending balance (in shares) at Jun. 30, 2023		117,662,134
Ending balance at Jun. 30, 2023	292,726	$ 1	2,169,911	(8,469)	(1,868,717)
Beginning balance (in shares) at Dec. 31, 2023		121,629,861
Beginning balance at Dec. 31, 2023	$ 158,684	$ 1	2,304,220	(3,675)	(2,141,862)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)	577,352	577,352
Issuance of common stock upon exercise of stock options	$ 2,577		2,577
Vesting of restricted stock units (in shares)		390,541
Common stock issued under employee stock purchase plan (in shares)		371,826
Common stock issued under employee stock purchase plan	7,212		7,212
Taxes paid related to net share settlement of restricted stock units	(4,784)		(4,784)
Stock-based compensation	54,276		54,276
Other comprehensive income (loss)	(1,965)			(1,965)
Net loss	(217,613)				(217,613)
Ending balance (in shares) at Jun. 30, 2024		122,969,580
Ending balance at Jun. 30, 2024	(1,613)	$ 1	2,363,501	(5,640)	(2,359,475)
Beginning balance (in shares) at Mar. 31, 2024		121,787,297
Beginning balance at Mar. 31, 2024	68,285	$ 1	2,329,930	(4,799)	(2,256,847)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)		540,561
Issuance of common stock upon exercise of stock options	2,364		2,364
Vesting of restricted stock units (in shares)		269,896
Common stock issued under employee stock purchase plan (in shares)		371,826
Common stock issued under employee stock purchase plan	7,212		7,212
Taxes paid related to net share settlement of restricted stock units	(3,240)		(3,240)
Stock-based compensation	27,235		27,235
Other comprehensive income (loss)	(841)			(841)
Net loss	(102,628)				(102,628)
Ending balance (in shares) at Jun. 30, 2024		122,969,580
Ending balance at Jun. 30, 2024	$ (1,613)	$ 1	$ 2,363,501	$ (5,640)	$ (2,359,475)