10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

_____________________

FORM 10-Q

_____________________

(Mark One)

☒    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended March 31, 2022

OR

☐    TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from                        to                        

Commission File Number: 001-38683

_____________________

GUARDANT HEALTH, INC.

(Exact Name of Registrant as Specified in its Charter)

_____________________

Delaware	45-4139254
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)

3000 Hanover Street

Palo Alto, California, 94304

Registrant’s telephone number, including area code: (855) 698-8887

_______________

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common Stock, $0.00001 par value per share	GH	The Nasdaq Global Select Market

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.     Yes  ☒    No  ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).    Yes  ☒    No  ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large Accelerated Filer	☒	Accelerated filer	☐
Non-accelerated filer	☐	Smaller reporting company	☐
Emerging growth company	☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes  ☐    No  ☒

As of April 29, 2022, the registrant had 101,923,322 shares of common stock, $0.00001 par value per share, outstanding.

GUARDANT HEALTH, INC.

FORM 10-Q

TABLE OF CONTENTS

	PART I – FINANCIAL INFORMATION
		Page
Item 1.	Unaudited Condensed Consolidated Financial Statements	4
	Condensed Consolidated Balance Sheets	4
	Condensed Consolidated Statements of Operations	5
	Condensed Consolidated Statements of Comprehensive Loss	6
	Condensed Consolidated Statements of Redeemable Noncontrolling Interest and Stockholders’ Equity	7
	Condensed Consolidated Statements of Cash Flows	8
	Notes to the Unaudited Condensed Consolidated Financial Statements	10
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	35
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	45
Item 4.	Controls and Procedures	46
	PART II – OTHER INFORMATION
Item 1.	Legal Proceedings	47
Item 1A.	Risk Factors	47
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	47
Item 3.	Defaults Upon Senior Securities	47
Item 4.	Mine Safety Disclosures	47
Item 5.	Other Information	47
Item 6.	Exhibits	48
	Signatures	49

FORWARD-LOOKING STATEMENTS

This Quarterly Report on Form 10-Q, including the section titled “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” contains forward-looking statements regarding future events and our future results that are based on our current expectations, estimates, forecasts and projections as well as the current beliefs and assumptions of our management, including about our business, our financial condition, our results of operations, our cash flows, and the industry and environment in which we operate. Statements that include words such as “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “would,” “could,” “should,” “intend” and “expect,” variations of these words, and similar expressions, are intended to identify forward-looking statements. These forward-looking statements speak only as of the date of this Quarterly Report on Form 10-Q and are subject to risks, uncertainties and assumptions that are difficult to predict. Therefore, actual results may differ materially and adversely from those expressed in any forward-looking statements. Factors that might cause or contribute to such differences include, but are not limited to, those discussed in Part I, Item 1A,“Risk Factors” and elsewhere in our Annual Report on Form 10-K for the year ended December 31, 2021, in Part II, Item 1A, “Risk Factors” and elsewhere in this Quarterly Report on Form 10-Q, and in other reports we file with the U.S. Securities and Exchange Commission, or the SEC. While forward-looking statements are based on the reasonable expectations of our management at the time that they are made, you should not rely on them. We undertake no obligation to revise or update publicly any forward-looking statements for any reason, whether as a result of new information, future events or otherwise, except as may be required by law.

Each of the terms the “Company,” “we,” “our,” “us” and similar terms used herein refer collectively to Guardant Health, Inc., a Delaware corporation, and its consolidated subsidiaries, unless otherwise stated. 

PART I—FINANCIAL INFORMATION

Item 1. Unaudited Condensed Consolidated Financial Statements

Guardant Health, Inc.

Condensed Consolidated Balance Sheets (unaudited)

(in thousands, except share and per share data)

	March 31, 2022		December 31, 2021
ASSETS
Current assets:
Cash and cash equivalents	$	573,604	$	492,202
Short-term marketable securities	388,662		440,546
Accounts receivable, net	84,331		97,652
Inventory	36,613		30,674
Prepaid expenses and other current assets, net	30,070		53,052
Total current assets	1,113,280		1,114,126
Long-term marketable securities	588,453		698,034
Property and equipment, net	151,322		124,461
Right-of-use assets, net	188,607		189,443
Intangible assets, net	13,727		14,207
Goodwill	3,290		3,290
Other assets, net	70,919		60,938
Total Assets(1)	$	2,129,598	$	2,204,499
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable	$	32,230	$	17,580
Accrued compensation	56,158		42,496
Accrued expenses	51,851		45,285
Noncontrolling interest liability	78,000		78,000
Deferred revenue	10,570		11,326
Total current liabilities	228,809		194,687
Convertible senior notes, net	1,135,463		1,134,821
Long-term operating lease liabilities	225,377		226,053
Other long-term liabilities	6,909		3,933
Total Liabilities(1)	1,596,558		1,559,494
Stockholders’ equity:
Preferred stock, par value of $0.00001 per share; 10,000,000 shares authorized, no shares issued and outstanding as of March 31, 2022 and December 31, 2021	—		—
Common stock, par value of $0.00001 per share; 350,000,000 shares authorized as of March 31, 2022, and December 31, 2021; 101,895,835 and 101,767,446 shares issued and outstanding as of March 31, 2022, and December 31, 2021, respectively	1		1
Additional paid-in capital	1,682,406		1,657,593
Accumulated other comprehensive loss	(18,314)		(4,764)
Accumulated deficit	(1,131,053)		(1,007,825)
Total Stockholders’ Equity	533,040		645,005
Total Liabilities and Stockholders’ Equity	$	2,129,598	$	2,204,499

(1) As of March 31, 2022 and December 31, 2021, this balance includes $16.9 million and $20.4 million of assets, respectively, that can be used only to settle obligations of the consolidated variable interest entity, or VIE and VIE’s subsidiaries, and $4.3 million and $4.3 million of liabilities of the consolidated VIE and VIE’s subsidiaries, respectively, for which their creditors do not have recourse to the general credit of the Company. See Note 3, Investment in Joint Venture.

The accompanying notes are an integral part of these condensed consolidated financial statements.

Guardant Health, Inc.

Condensed Consolidated Statements of Operations (unaudited)

(in thousands, except per share data)

	Three Months Ended March 31,
	2022		2021
Revenue:
Precision oncology testing	$	84,136	$	63,729
Development services and other	11,963		14,936
Total revenue	96,099		78,665
Costs and operating expenses:
Cost of precision oncology testing	30,684		23,590
Cost of development services and other	1,297		5,157
Research and development expense	81,757		55,508
Sales and marketing expense	64,432		34,338
General and administrative expense	41,267		67,935
Total costs and operating expenses	219,437		186,528
Loss from operations	(123,338)		(107,863)
Interest income	778		1,551
Interest expense	(644)		(646)
Other income (expense), net	(48)		(290)
Loss before provision for income taxes	(123,252)		(107,248)
Provision for (benefit from) income taxes	(24)		110
Net loss	(123,228)		(107,358)
Adjustment of redeemable noncontrolling interest	—		(2,300)
Net loss attributable to Guardant Health, Inc. common stockholders	$	(123,228)	$	(109,658)
Net loss per share attributable to Guardant Health, Inc. common stockholders, basic and diluted	$	(1.21)	$	(1.09)
Weighted-average shares used in computing net loss per share attributable to Guardant Health, Inc. common stockholders, basic and diluted	101,853		100,955

The accompanying notes are an integral part of these condensed consolidated financial statements.

5

Guardant Health, Inc.

Condensed Consolidated Statements of Comprehensive Loss (unaudited)

(in thousands)

	Three Months Ended March 31,
	2022		2021
Net loss	$	(123,228)	$	(107,358)
Other comprehensive loss, net of tax impact:
Unrealized loss on available-for-sale securities	(12,758)		(706)
Foreign currency translation adjustments	(792)		(1,087)
Other comprehensive loss	(13,550)		(1,793)
Comprehensive loss	$	(136,778)	$	(109,151)
Comprehensive loss attributable to redeemable noncontrolling interest	—		(2,300)
Comprehensive loss attributable to Guardant Health, Inc.	$	(136,778)	$	(111,451)

The accompanying notes are an integral part of these condensed consolidated financial statements.

6

Guardant Health, Inc.

Condensed Consolidated Statements of Redeemable Noncontrolling Interest and Stockholders’ Equity (unaudited)

(in thousands, except share data)

	Three Months Ended March 31, 2022
	Common Stock			Additional Paid-in Capital		Accumulated Other Comprehensive Income (Loss)		Accumulated Deficit		Total Stockholders’ Equity
	Shares	Amount
Balance as of January 1, 2022	101,767,446	$	1	$	1,657,593	$	(4,764)	$	(1,007,825)	$	645,005
Issuance of common stock upon exercise of stock options	105,218	—		963		—		—		963
Vesting of restricted stock units	23,171	—		—		—		—		—
Vesting of common stock exercised early	—	—		8		—		—		8
Taxes paid related to net share settlement of restricted stock units	—	—		(957)		—		—		(957)
Stock-based compensation	—	—		24,799		—		—		24,799
Other comprehensive loss	—	—		—		(13,550)		—		(13,550)
Net loss	—	—		—		—		(123,228)		(123,228)
Balance as of March 31, 2022	101,895,835	$	1	$	1,682,406	$	(18,314)	$	(1,131,053)	$	533,040

			Three Months Ended March 31, 2021
	Redeemable Noncontrolling Interest		Common Stock			Additional Paid-in Capital		Accumulated Other Comprehensive Income (Loss)		Accumulated Deficit		Total Stockholders’ Equity
			Shares	Amount
Balance as of January 1, 2021	$	57,100	100,213,985	$	1	$	1,902,389	$	2,697	$	(606,592)	$	1,298,495
Cumulative effect adjustment for ASU 2020-06 adoption	—		—	—		(330,403)		—		4,437		(325,966)
Issuance of common stock upon exercise of stock options	—		282,879	—		4,462		—		—		4,462
Vesting of restricted stock units	—		588,789	—		—		—		—		—
Vesting of common stock exercised early	—		—	—		13		—		—		13
Taxes paid related to net share settlement of restricted stock units	—		—	—		(73,576)		—		—		(73,576)
Stock-based compensation	—		—	—		55,069		—		—		55,069
Adjustment of redeemable noncontrolling interest	2,300		—	—		—		—		(2,300)		(2,300)
Other comprehensive loss, net of tax impact	—		—	—		—		(1,793)		—		(1,793)
Net loss	—		—	—		—		—		(107,358)		(107,358)
Balance as of March 31, 2021	$	59,400	101,085,653	$	1	$	1,557,954	$	904	$	(711,813)	$	847,046

The accompanying notes are an integral part of these condensed consolidated financial statements.

7

Guardant Health, Inc.

Condensed Consolidated Statements of Cash Flows (unaudited)

(in thousands)

	Three Months Ended March 31,
	2022		2021
OPERATING ACTIVITIES:
Net loss	$	(123,228)	$	(107,358)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	7,201		5,010
Non-cash operating lease costs	6,949		3,932
Re-valuation of contingent consideration	2,390		—
Non-cash stock-based compensation	24,799		55,069
Amortization of debt issuance costs	642		641
Amortization of premium (discount) on marketable securities	2,449		3,259
Other	21		—
Changes in operating assets and liabilities:
Accounts receivable, net	13,299		5,260
Inventory	(5,937)		(6,160)
Prepaid expenses and other current assets, net	21,882		521
Other assets, net	3,846		1,202
Accounts payable	(753)		11,986
Accrued compensation	13,662		8,900
Accrued expenses and other liabilities	8,022		4,399
Operating lease liabilities	(3,106)		(2,762)
Deferred revenue	(757)		(190)
Net cash used in operating activities	(28,619)		(16,291)
INVESTING ACTIVITIES:
Purchase of marketable securities	(163,742)		(70,654)
Maturity of marketable securities	310,000		204,110
Purchase of non-marketable equity and other related investments	(12,750)		—
Purchase of property and equipment	(22,700)		(9,586)
Net cash provided by investing activities	110,808		123,870
FINANCING ACTIVITIES:
Payments made on finance lease obligations	(18)		(55)
Proceeds from issuance of common stock upon exercise of stock options	963		4,462
Taxes paid related to net share settlement of restricted stock units	(957)		(73,576)
Payment of offering costs related to borrowings on convertible senior notes	—		(784)
Net cash used in financing activities	(12)		(69,953)
Net effect of foreign exchange rate changes on cash, cash equivalents and restricted cash	(792)		(1,087)
Net increase in cash, cash equivalents and restricted cash	81,385		36,539
Cash, cash equivalents and restricted cash—Beginning of period	492,288		832,977
Cash, cash equivalents and restricted cash—End of period	$	573,673	$	869,516
Supplemental Disclosures of Cash Flow Information:
Operating lease liabilities arising from obtaining right-of-use assets	$	3,940	$	170,847

8

	Three Months Ended March 31,
	2022		2021
Supplemental Disclosures of Noncash Investing and Financing Activities:
Purchase of property and equipment included in accounts payable and accrued expenses	$	19,751	$	5,881
Property and equipment acquired under finance leases	$	—	$	238
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	$	573,604	$	869,372
Restricted cash – included in other assets, net	69		144
Total cash, cash equivalents and restricted cash	$	573,673	$	869,516

The accompanying notes are an integral part of these condensed consolidated financial statements.

9

 Guardant Health, Inc.

Notes to Unaudited Condensed Consolidated Financial Statements

1.    Description of Business

Guardant Health, Inc., or the Company, is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. Today the Company's proprietary tests are helping to realize the full potential of precision oncology by providing patients and their doctors critical insights that can inform decisions at all stages of the disease, from detecting early signs of cancer, to monitoring cancer recurrence, to guiding treatment decisions. By looking at the unique dimensions of cancer found in blood, including genomic alterations, methylation, and fragmentomics, the Company is unlocking insights that can increasingly help patients across all stages of cancer, including at its earliest, when it’s most treatable. The Company provides its Guardant360 LDT, Guardant360 CDx and GuardantOMNI blood-based tests and Guardant360 TissueNext tissue-based tests for advanced stage cancer, Guardant Reveal blood-based tests to detect residual and recurring disease in Stage II-III colorectal cancer patients, and Guardant360 Response blood-based tests to predict patient response to immunotherapy or targeted therapy 8 weeks earlier than current standard-of-care imaging. In April 2022, the Company presented new data from its broad portfolio of blood tests at the American Association for Cancer Research Annual Meeting which demonstrated the ability of the Company’s investigational next-generation Guardant SHIELD multi-cancer assay to accurately detect early-stage cancers and identify the tumor tissue of origin with high accuracy. To help identify cancer at the earliest stages, in May 2022, the Company launched Shield LDT, a blood-based test to detect early signs of colorectal cancer in average-risk adults age 45 or older who show no symptoms and are not up to date with recommended screening guidelines. From a simple blood draw, the test uses a novel multimodal approach to detect colorectal cancer signals in the bloodstream, including DNA that is shed by tumors. Using data collected from the Company's tests, the Company has also developed the GuardantINFORM platform to further accelerate precision oncology drug development by biopharmaceutical companies by offering them an in-silico research platform to further unlock insights into tumor evolution and treatment resistance across various biomarker-driven cancers.

The Company was incorporated in Delaware in December 2011 and is headquartered in Palo Alto, California. In May 2018, the Company formed and capitalized Guardant Health AMEA, Inc., or the Joint Venture, in the United States with an affiliate of SoftBank Vision Fund (AIV M1) L.P., or SoftBank. Under the terms of the joint venture agreement, the Company holds a 50% ownership interest in the Joint Venture. In November 2021, the Company exercised its call right contained in the Joint Venture agreement with SoftBank to purchase all of the shares held by SoftBank and its affiliates (see Note 3, Investment in Joint Venture).

2.    Summary of Significant Accounting Policies

Basis of Presentation

The Company’s condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America, or GAAP. The accompanying condensed consolidated financial statements include the accounts of Guardant Health, Inc., its consolidated Joint Venture and majority owned subsidiaries. Other stockholders’ interests in the Joint Venture are shown in the condensed consolidated financial statements as noncontrolling interest liability. All significant intercompany balances and transactions have been eliminated in consolidation.

The Company believes that its existing cash and cash equivalents and marketable securities as of March 31, 2022, will be sufficient to allow the Company to fund its current operating plan through at least a period of one year after the date the accompanying condensed consolidated financial statements are issued. As the Company continues to incur losses, its transition to profitability is dependent upon a level of revenues adequate to support the Company’s cost structure. If the Company’s transition to profitability is not consistent with its current operating plan, the Company may have to seek additional capital.

Use of Estimates

The preparation of condensed consolidated financial statements in conformity with GAAP requires management to make certain estimates, judgments and assumptions that affect the reported amounts of assets and liabilities and the related disclosures at the date of the condensed consolidated financial statements, as well as the reported amounts of revenues and expenses during the periods presented. The Company bases its estimates on historical experience and other market-specific or other relevant assumptions that it believes to be reasonable under the circumstances. Estimates are used in several areas including, but not limited to, estimation of variable consideration, estimation of credit losses, standalone selling price allocation included in contracts with multiple performance obligations,

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goodwill and identifiable intangible assets, stock-based compensation, incremental borrowing rate for operating leases, contingencies, certain inputs into the provision for (benefit from) income taxes, including related reserves, valuation of non-marketable securities, valuation of redeemable noncontrolling interest and noncontrolling interest liability, among others. These estimates generally involve complex issues and require judgments, involve the analysis of historical results and prediction of future trends, can require extended periods of time to resolve and are subject to change from period to period. Actual results may differ materially from management’s estimates.

The severity of the impact on the Company's business for the remainder of calendar year 2022 and beyond will depend on a number of factors, including, but not limited to, the duration and severity of the pandemic, and the impact of any variants of the virus, the extent and severity of the impact on the Company's customers and suppliers, the continued disruption to demand for the Company's products and services, and the impact of the global business and economic environment on liquidity and the availability of capital, all of which are uncertain and cannot be predicted.

Unaudited Interim Condensed Financial Statements

The accompanying condensed consolidated balance sheet as of March 31, 2022, the condensed consolidated statements of operations for the three months ended March 31, 2022, and 2021, the condensed consolidated statements of comprehensive loss for the three months ended March 31, 2022, and 2021, the condensed consolidated statements of redeemable noncontrolling interest and stockholders’ equity for the three months ended March 31, 2022, and 2021, and cash flows for the three months ended March 31, 2022, and 2021, and the related interim condensed consolidated disclosures are unaudited. The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with GAAP for interim financial information and in accordance with the instructions to Form 10-Q and Rule 10-01 of Regulation S-X of the Securities Act of 1933, as amended, or the Securities Act. Accordingly, they do not include all of the information and notes required by GAAP for complete financial statements. These unaudited condensed consolidated financial statements include all adjustments, consisting only of normal recurring accruals that the Company believes are necessary to fairly state the financial position and the results of the Company’s operations and cash flows for interim periods in accordance with GAAP. Interim-period results are not necessarily indicative of results of operations or cash flows for a full year or any subsequent interim period.

The accompanying condensed consolidated financial statements should be read in conjunction with the Company’s audited financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021.

Foreign Currency

The functional currency of the subsidiaries of the consolidated Joint Venture is the local currency. The assets and liabilities of the subsidiaries are translated into U.S. dollars at exchange rates in effect at each balance sheet date, with the resulting translation adjustments recorded to a separate component of accumulated other comprehensive loss within stockholders’ equity. Income and expense accounts are translated at average exchange rates during the period. Foreign currency transaction gains and losses resulting from transactions denominated in a currency other than the functional currency are recognized in the condensed consolidated statements of operations. For the three months ended March 31, 2022, and 2021, foreign currency transaction gains and losses were immaterial.

Restricted Cash

Restricted cash consists of payroll withholding related to the Company's enrollment in certain voluntary disability insurance plan. Restricted cash balance was $0.1 million and $0.1 million as of March 31, 2022, and December 31, 2021, respectively, which was included in other assets in the accompanying condensed consolidated balance sheets.

Non-Marketable Securities

The Company acquires certain equity investments in private companies to promote business and strategic objectives. The Company's investments in non-marketable equity securities do not give the Company the ability to control or exercise significant influence over the investee. The Company's non-marketable equity and other related investments totaled $52.2 million and $39.4 million as of March 31, 2022, and December 31, 2021, respectively, and are included in other assets, net on the accompanying condensed consolidated balance sheets. Non-marketable securities are subject to periodic impairment reviews and adjustments for observable price changes from orderly transactions. The Company's evaluation of impairment of such non-marketable securities is based on adverse changes in market conditions and the regulatory or economic environment, qualitative and quantitative analysis of the operating performance of the investee; changes in operating structure or management of the investee; additional funding requirements; and the investee’s ability to remain in business. Pursuant to one of the investments in non-marketable

11

securities purchased by the Company, the Company acquired rights to purchase the investee at a pre-determined price subject to additional adjustments based on the performance of the investee, on or before December 31, 2022. As of March 31, 2022, no impairment or downward adjustments to the carrying value of non-marketable securities have been recorded. The Company’s assessment of these factors in determining whether an impairment exists could change in the future due to new developments or changes in applied assumptions.

Concentration of Risk

The Company is subject to credit risk from its portfolio of cash equivalents held at one commercial bank and investments in marketable securities. The Company limits its exposure to credit losses by investing in money market funds through a U.S. bank with high credit ratings. The Company’s cash may consist of deposits held with banks that may at times exceed federally insured limits, however, its exposure to credit risk in the event of default by the financial institution is limited to the extent of amounts recorded on the condensed consolidated balance sheets. The Company performs evaluations of the relative credit standing of these financial institutions to limit the amount of credit exposure.

The Company also invests in investment-grade debt instruments and has policy limits for the amount it can invest in any one type of security, except for securities issued or guaranteed by the U.S. government. The goals of the Company’s investment policy, in order of priority, are as follows: safety and preservation of principal and diversification of risk; liquidity of investments sufficient to meet cash flow requirements; and a competitive after-tax rate of return. Under its investment policy, the Company limits amounts invested in such securities by credit rating, maturity, investment type and issuer, as a result, the Company is not exposed to any significant concentrations of credit risk from these financial instruments.

The Company is subject to credit risk from its accounts receivable. The majority of the Company’s accounts receivable arises from the provision of precision oncology services and development services and other in the United States and are primarily with biopharmaceutical companies with high credit ratings. The Company has not experienced any material losses related to receivables from individual customers, or groups of customers. The Company does not require collateral. Accounts receivable are recorded at net amount.

A significant customer is a biopharmaceutical customer or a clinical testing payer that represents 10% or more of the Company’s total revenue or accounts receivable balance. Revenue attributable to each significant customer, including its affiliated entities, as a percentage of the Company’s total revenue, for the respective period, and accounts receivable balance attributable to each significant customers, including its affiliated entities, as a percentage of the Company’s total accounts receivable balance, at the respective condensed consolidated balance sheet date, are as follows:

	Revenue				Accounts Receivable, Net
	Three Months Ended March 31,				March 31, 2022		December 31, 2021
	2022		2021
	(unaudited)				(unaudited)
Customer A	30	%	25	%	10	%	13	%
Customer B	*		*		11	%	10	%
Customer C	*		*		*		13	%
Customer D	*		*		16	%	*

*    less than 10%

The Company is also subject to credit risk from its other receivables and other assets. The Company's other receivables and other assets include payments due from a third-party in relation to the settlement of a patent dispute reached in August 2020 for $8.0 million payable over a period of 6 years. In December 2020, the Company received the first installment payment of $1.0 million, and in December 2021, the Company received the second installment payment of $1.1 million. The Company has evaluated and recorded a credit loss for the remaining $5.9 million considering the third-party's credit worthiness and lack of financial history.

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The following table presents the receivable and the related credit loss amounts:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Prepaid expenses and other current assets:
Gross Amount	$	1,100	$	—
Allowance for Credit Losses	(1,100)		—
Net Amount	$	—	$	—
Other assets:
Gross Amount	$	4,800	$	5,900
Allowance for Credit Losses	(4,800)		(5,900)
Net Amount	$	—	$	—

The following table summarizes the allowance for credit losses activities:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
Prepaid expenses and other current assets:
Allowance for credit losses—Beginning of period	$	—	$	—
Reclassification	1,100		1,100
Allowance for credit losses—End of period	$	1,100	$	1,100
Other assets:
Allowance for credit losses—Beginning of period	$	5,900	$	7,000
Reclassification	(1,100)		(1,100)
Allowance for credit losses—End of period	$	4,800	$	5,900

Accounts Receivable, Net

Accounts receivable represent valid claims against commercial and governmental payers, biopharmaceutical companies, research institutes and international distributors, including unbilled receivables, and royalty payments due from third parties for licensing the Company’s technologies. Unbilled receivables include balances due from biopharmaceutical customers related to development services and other revenues that are recognized upon the achievement of performance-based milestones but prior to the achievement of contractual billing rights. As of March 31, 2022, and December 31, 2021, the Company had unbilled receivables of $3.1 million and $5.7 million, respectively.

The Company evaluates the collectability of its accounts receivable based on historical collection trends, the financial condition of payment partners, and external market factors and provides for an allowance for potential credit losses based on management’s best estimate of the amount of probable credit losses. As of March 31, 2022, and December 31, 2021, the Company had immaterial allowance for credit losses related to its accounts receivable.

Asset Acquisition

If an acquisition of an asset or group of assets does not meet the definition of a business, the transaction is accounted for as an asset acquisition rather than a business combination. An asset acquisition does not result in the recognition of goodwill and transaction costs are capitalized as part of the cost of the asset or group of assets acquired. Transaction costs allocated to in-process research and development technology with no future alternate use is expensed as incurred. The total consideration is allocated to the various intangible assets acquired on a relative fair value basis. Cash paid in connection of purchase of in-process research and development technology in an asset acquisition is presented within the investing section of the condensed consolidated statement of cash flows.

Goodwill and Intangible Assets, net

Intangible assets related to in-process research and development costs, or IPR&D, acquired in a business combination are considered to be indefinite-lived until the completion or abandonment of the associated research

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and development efforts. If and when development is complete, the associated assets would be deemed finite-lived and would then be amortized based on their respective estimated useful lives at that point in time. Prior to completion of the research and development efforts, the assets are considered indefinite-lived. During this period, the assets will not be amortized but will be tested for impairment on an annual basis and between annual tests if the Company becomes aware of any events occurring or changes in circumstances that would indicate a reduction in the fair value of the IPR&D projects below their respective carrying amounts.

Goodwill represents the excess of the purchase price over the fair value of net identifiable assets and liabilities. Goodwill and IPR&D are not amortized but are tested for impairment at least annually during the fourth fiscal quarter, or if circumstances indicate their value may no longer be recoverable. The Company continues to operate in one segment, which is considered to be the sole reporting unit and, therefore, goodwill was tested for impairment at the enterprise level. As of March 31, 2022, there has been no impairment of goodwill or IPR&D.

Intangible assets are carried at cost, net of accumulated amortization. The Company does not have intangible assets with indefinite useful lives other than goodwill and the acquired IPR&D. Amortization is recorded on a straight-line basis over the intangible asset's useful life, which is approximately 6—12 years.

Post-acquisition Contingent Consideration

Post-acquisition contingent consideration is recognized over the service period, subject to meeting the respective service requirements and performance metrics. For the three months ended March 31, 2022, and 2021, the Company recorded post-acquisition contingent consideration expense of $2.1 million and zero, respectively, in research and development expenses on the Company's condensed consolidated statement of operations.

Leases

The Company determines if an arrangement contains a lease at inception. Operating lease right-of-use, or ROU, assets and operating leases liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. ROU assets also include any initial direct costs incurred and any lease payments made at or before the lease commencement date, less lease incentives received or receivable. The Company uses its incremental borrowing rate based on the information available at the commencement date in determining the lease liabilities, as the Company's leases generally do not provide an implicit rate. Lease terms may include options to extend or terminate when the Company is reasonably certain the option will be exercised. Lease expense is recognized on a straight-line basis over the lease term. The Company also has lease arrangements with lease and non-lease components. The Company elected the practical expedient not to separate non-lease components from lease components for the Company’s facility leases. The Company also elected to apply the short-term lease measurement and recognition exemption in which ROU assets and lease liabilities are not recognized for leases with terms of 12 months or less.

Convertible Senior Notes

Upon early adoption of ASU 2020-06, Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity on January 1, 2021, the Company reclassified the carrying amount of the equity component of the cash conversion feature including the allocated debt issuance costs from additional paid-in capital to convertible senior notes, net. Convertible senior notes are accounted for as a liability and measured at their amortized cost. Transaction costs related to the issuance of the notes are netted with the liability and are amortized to interest expense over the term of the notes, using an effective interest rate method.

Revenue Recognition

The Company derives revenue from the provision of precision oncology testing services provided to its ordering physicians and biopharmaceutical customers, as well as from biopharmaceutical research and development services provided to its biopharmaceutical customers. Precision oncology testing services include genomic profiling and the delivery of other genomic information derived from the Company’s platform. Development services and other include companion diagnostic development, clinical study setup, monitoring and maintenance, information solutions and laboratory services, and other miscellaneous revenue streams. The Company currently receives payments from third-party commercial and governmental payers, certain hospitals and oncology centers and individual patients, as well as biopharmaceutical companies, research institutes and international distributors.

Revenues are recognized when control of services is transferred to customers, in an amount that reflects the consideration the Company expects to be entitled to in exchange for those services. ASC 606 provides for a five-step model that includes identifying the contract with a customer, identifying the performance obligations in the contract,

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determining the transaction price, allocating the transaction price to the performance obligations, and recognizing revenue when, or as, an entity satisfies a performance obligation.

Precision oncology testing

The Company recognizes revenue from the sale of its precision oncology tests for clinical customers, including certain hospitals, cancer centers, other institutions and patients, at the time results of the test are reported to physicians. Most precision oncology tests requested by clinical customers are sold without a written agreement; however, the Company determines an implied contract exists with its clinical customers. The Company identifies each sale of its test to a clinical customer as a single performance obligation. With the exception of certain limited contracted arrangements with insurance carriers and other institutions where the transaction price is fixed, a stated contract price does not exist and the transaction price for each implied contract with clinical customers represents variable consideration. The Company estimates the variable consideration under the portfolio approach and considers the historical reimbursement data from third-party commercial and governmental payers and patients, as well as known or anticipated reimbursement trends not reflected in the historical data. The Company monitors the estimated amount to be collected in the portfolio at each reporting period based on actual cash collections in order to assess whether a revision to the estimate is required. Both the estimate and any subsequent revision contain uncertainty and require the use of significant judgment in the estimation of the variable consideration and application of the constraint for such variable consideration. The Company analyzes its actual cash collections over the expected reimbursement period and compares it with the estimated variable consideration for each portfolio and any difference is recognized as an adjustment to estimated revenue after the expected reimbursement period, subject to assessment of the risk of future revenue reversal. For the three months ended March 31, 2022, and 2021, the Company recorded $2.0 million and $5.1 million as revenue, respectively, resulting from cash collections exceeding the estimated variable consideration related to samples processed in previous periods, including revenue received from successful appeals of reimbursement denials, net of recoupments.

Revenue from sales of precision oncology tests to biopharmaceutical customers are based on a negotiated price per test or on the basis of an agreement to provide certain testing volume over a defined period. The Company identifies its promise to transfer a series of distinct tests to biopharmaceutical customers as a single performance obligation. Precision oncology tests to biopharmaceutical customers are generally billed at a fixed price for each test performed. For agreements involving testing volume to be satisfied over a defined period, revenue is recognized over time based on the number of tests performed as the performance obligation is satisfied over time. Results of the Company’s precision oncology services are delivered electronically, and as such there are no shipping or handling fees incurred by the Company or billed to customers.

Development services and other

The Company performs development services for its biopharmaceutical customers utilizing its precision oncology information platform. Development services typically represent a single performance obligation as the Company performs a significant integration service, such as analytical validation and regulatory submissions. The individual promises are not separately identifiable from other promises in the contracts and, therefore, are not distinct. However, under certain contracts, a biopharmaceutical customer may engage the Company for multiple distinct development services which are both capable of being distinct and separately identifiable from other promises in the contracts and, therefore, distinct performance obligations.

The Company collaborates with pharmaceutical companies in the development of new drugs. As part of these collaborations, the Company provides services related to regulatory filings to support companion diagnostic device submissions for the Company’s testing panels. Under these collaborations, the Company generates revenue from achievement of milestones, as well as provision of on-going support. For development services performed, the Company is compensated through a combination of an upfront fee and performance-based, non-refundable regulatory and other developmental milestone payments. The transaction price of the Company's development services contracts typically represents variable consideration. Application of the constraint for variable consideration to milestone payments is an area that requires significant judgment. The Company evaluates factors such as the scientific, clinical, regulatory, commercial, and other risks that must be managed to achieve the respective milestone and the level of effort and investment required to achieve the respective milestone. In making this assessment, the Company considers its historical experience with similar milestones, the degree of complexity and uncertainty associated with each milestone, and whether achievement of the milestone is dependent on parties other than the Company. The constraint for variable consideration is applied such that it is probable a significant reversal of revenue will not occur when the uncertainty associated with the contingency is resolved. Application of the constraint for variable consideration is assessed and updated at each reporting period as a revision to the estimated transaction price.

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The Company recognizes development services revenue over the period in which biopharmaceutical research and development services are provided. Specifically, the Company recognizes revenue using an input method to measure progress, utilizing costs incurred to-date relative to total expected costs as its measure of progress. The Company assesses the changes to the total expected cost estimates as well as any incremental fees negotiated resulting from changes to the scope of the original contract in determining the revenue recognition at each reporting period. For development of new products or services under these arrangements, costs incurred before technological feasibility is reached are included as research and development expenses in the Company’s condensed consolidated statements of operations, while costs incurred thereafter are recorded as cost of development services and other.

The Company also has other miscellaneous revenue streams that are recognized in addition to development services noted above such as clinical study setup, monitoring and maintenance, testing development and support, GuardantConnect, GuardantINFORM, and kits fulfillment related revenues. Revenues related to clinical study setup, monitoring and maintenance, testing development and support, GuardantConnect, and GuardantINFORM are generally recognized over time based on an input method to measure progress in the period when the associated services have been performed. Kits fulfillment related revenues are recognized when such products are delivered. In addition, the Company derives sales-based royalty revenues from licensing its technologies. Royalty revenues are recognized in the period when royalty-bearing sales occur.

Contracts with multiple performance obligations

Contracts with biopharmaceutical customers may include multiple distinct performance obligations, such as provision of precision oncology testing, biopharmaceutical research and development services, and clinical study enrollment assistance, among others. The Company evaluates the terms and conditions included within its contracts with biopharmaceutical customers to ensure appropriate revenue recognition, including whether services are considered distinct performance obligations that should be accounted for separately versus together. The Company first identifies material promises, in contrast to immaterial promises or administrative tasks, under the contract, and then evaluates whether these promises are both capable of being distinct and distinct within the context of the contract. In assessing whether a promised service is capable of being distinct, the Company considers whether the customer could benefit from the service either on its own or together with other resources that are readily available to the customer, including factors such as the research, development, and commercialization capabilities of a third party as well as the availability of the associated expertise in the general marketplace. In assessing whether a promised service is distinct within the context of the contract, the Company considers whether it provides a significant integration of the services, whether the services significantly modify or customize one another, or whether the services are highly interdependent or interrelated.

For contracts with multiple performance obligations, the transaction price is allocated to the separate performance obligations on a relative standalone selling price basis. The Company determines standalone selling price by considering the historical selling price of these performance obligations in similar transactions as well as other factors, including, but not limited to, the price that customers in the market would be willing to pay, competitive pricing of other vendors, industry publications and current pricing practices, and expected costs of satisfying each performance obligation plus appropriate margin.

Deferred revenue

Deferred revenue, which is a contract liability, consists primarily of payments received in advance of revenue recognition from contracts with customers. For example, development services and other contracts with biopharmaceutical customers often contain upfront payments which results in the recording of deferred revenue to the extent cash is received prior to the Company's performance of the related services. Contract liabilities are relieved as the Company performs its obligations under the contract and revenue is consequently recognized. As of March 31, 2022, and December 31, 2021, the deferred revenue balance was $10.6 million and $11.3 million, respectively. Revenue recognized in the three months ended March 31, 2022 that was included in the deferred revenue balance as of December 31, 2021 was $3.5 million, and revenue recognized in the three months ended March 31, 2021 that was included in the deferred revenue balance as of December 31, 2020 was $5.0 million, respectively.

Transaction price allocated to the remaining performance obligations

Transaction price allocated to remaining performance obligations represents contracted revenue that has not yet been recognized, which includes deferred revenue and non-cancelable amounts that will be invoiced and recognized as revenues in future periods. The Company expects to recognize substantially all of the remaining transaction price in the next 12 months.

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Costs of Precision Oncology Testing

Cost of precision oncology testing generally consists of cost of materials, direct labor including bonus, benefit and stock-based compensation, equipment and infrastructure expenses associated with processing test samples (including sample accessioning, library preparation, sequencing, quality control analyses and shipping charges to transport blood samples), freight, curation of test results for physicians and license fees due to third parties. Infrastructure expenses include depreciation of laboratory equipment, rent costs, amortization of leasehold improvements and information technology costs. Costs associated with performing the Company’s tests are recorded as the tests are performed regardless of whether revenue was recognized with respect to that test. Royalties for licensed technology calculated as a percentage of revenues generated using the associated technology are recorded as expense at the time the related revenues are recognized. One-time royalty payments related to signing of license agreements or other milestones, such as issuance of new patents, are amortized to expense over the expected useful life of the applicable patent rights.

Cost of Development Services and Other

Cost of development service and other primarily includes costs incurred for the performance of development services requested by the Company’s biopharmaceutical customers and other revenues included as noted above. For development of new products, costs incurred before technological feasibility has been achieved are reported as research and development expenses, while costs incurred thereafter are reported as cost of development services and other.

Research and Development Expenses

Research and development expenses are comprised of costs incurred to develop technology and include compensation and benefits, reagents and supplies used in research and development laboratory work, infrastructure expenses, including allocated facility occupancy and information technology costs, contract services and other outside costs. Research and development costs are expensed as incurred. Payments made prior to the receipt of goods or services to be used in research and development are deferred and recognized as expense in the period in which the related goods are received or services are rendered. Costs to develop the Company’s technology capabilities are recorded as research and development unless they meet the criteria to be capitalized as internal-use software costs.

Stock-Based Compensation

Stock-based compensation related to stock options granted to the Company’s and the Joint Venture's employees, directors and nonemployees is measured at the grant date based on the fair value of the award. The fair value is recognized as expense over the requisite service period, which is generally the vesting period of the respective awards. Compensation expense for stock options with performance metrics is calculated based upon expected achievement of the metrics specified in the grant.

The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock options granted under the 2012 Stock Plan, the 2018 Incentive Award Plan, and the Joint Venture's 2020 Equity Incentive Plan, and stock purchase rights granted under the 2018 Employee Stock Purchase Plan. The Black-Scholes option-pricing model requires assumptions to be made related to the expected term of an award, expected volatility, risk-free rate and expected dividend yield. The board of directors of the Joint Venture has determined the fair value of common stock of the Joint Venture. Forfeitures are accounted for as they occur.

For market-based restricted stock units, the Company derives the requisite service period using the Monte Carlo simulation model and the related compensation expense is recognized over the derived service period using an accelerated attribution model commencing on the grant date. Stock-based compensation expense will be recorded regardless of whether the market conditions are achieved or not. If the related market condition is achieved earlier than its estimated derived service period, the stock-based compensation expense will be accelerated, and a cumulative catch-up expense will be recorded during the period in which the market condition is met.

The Company measures the grant date fair value of its service-based and performance-based restricted stock units issued to employees based on the closing market price of the common stock on the date of grant. For restricted stock units with only service-based vesting conditions, compensation expense is recognized in the Company’s condensed consolidated statement of operations on a straight-line basis over the requisite service period. Compensation expense for restricted stock units with performance metrics is calculated based upon expected achievement of the metrics specified in the grant, and is recognized in the Company’s condensed consolidated statement of operations using an accelerated attribution model over the requisite service period for each separately vesting portion of the award.

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Net Loss Per Share Attributable to Common Stockholders

The Company calculates basic net loss per share attributable to common stockholders by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding for the period. The diluted net loss per share attributable to common stockholders is computed by giving effect to all potential dilutive common stock equivalents outstanding for the period determined using the treasury stock method or the as-if converted method, as appropriate. For purposes of this calculation, stock options, restricted stock units, shares issuable pursuant to the employee stock purchase plan, shares subject to repurchase from early exercised options and contingently issuable shares under the convertible senior notes are considered common stock equivalents but have been excluded from the calculation of diluted net loss per share attributable to common stockholders as their effect is anti-dilutive.

3.    Investment in Joint Venture

Variable Interest Entity, or VIE

In May 2018, the Company and an affiliate of SoftBank formed and capitalized the Joint Venture for the sale, marketing and distribution of the Company’s tests in all areas worldwide, outside of North America, Central America, South America, the United Kingdom, all other member states of the European Union as of May 9, 2017, Iceland, Norway, Switzerland and Turkey. The Company expects to rely on the Joint Venture to accelerate commercialization of its products in Asia, the Middle East and Africa.

Under the terms of the joint venture agreement, the Company paid $9.0 million for 40,000 shares of common stock, or 50% ownership interest, of the Joint Venture, and the affiliate of SoftBank contributed $41.0 million for 40,000 shares of common stock, or the other 50% ownership interest, of the Joint Venture. In June 2020, an amended and restated certificate of incorporation of the Joint Venture, as approved by the board of directors of the Joint Venture, was filed with the Secretary of State of the State of Delaware. The amended and restated certificate of incorporation, among other things, increased the number of authorized shares of common stock to 89,000,000 shares consisting of 80,000,000 shares of Class A common stock and 9,000,000 shares of Class B (non-voting) common stock; and authorized 80,000,000 shares of Series A preferred stock. Pursuant to the amended and restated certificate of incorporation, each share of common stock held by the Company and the affiliate of SoftBank was reclassified and exchanged for 1,000 shares of Series A preferred stock. As a result, each of the Company and the affiliate of SoftBank held 40,000,000 shares of Series A preferred stock. The holders of Series A preferred stock are entitled to receive dividends at the rate of $0.05 per share if and when declared by the board of directors of the Joint Venture. In June 2020, the board of directors of the Joint Venture authorized the adoption of the Joint Venture’s 2020 Equity Incentive Plan pursuant to which 4,595,555 shares of Class B common stock have been reserved for issuance. As of March 31, 2022, and December 31, 2021, 1,184,428 and 602,408 shares of Class B common stock have been issued and outstanding, respectively, and no shares of Class A common stock have been issued and outstanding. As of March 31, 2022, and December 31, 2021, 80,000,000 shares of Series A preferred stock have been issued and outstanding.

Under the terms of the joint venture agreement, neither party is obligated to make any further capital contribution, in cash or otherwise, to the Joint Venture. The Joint Venture is deemed to be a VIE and the Company has been identified as the VIE’s primary beneficiary. As the primary beneficiary, the Company has consolidated the financial position, results of operations and cash flows of the Joint Venture in its financial statements and all intercompany balances have been eliminated in consolidation.

As of March 31, 2022, and December 31, 2021, the Joint Venture had total assets of approximately $16.9 million and $20.4 million, respectively, which were primarily comprised of cash, property and equipment and right-of-use assets. Although the Company consolidates the Joint Venture, the legal structure of the Joint Venture limits the recourse that its creditors will have over the Company’s general credit or assets. Similarly, the assets held in the Joint Venture can be used only to settle obligations of the Joint Venture. As of March 31, 2022, and December 31, 2021, the Company has not provided financial or other support to the Joint Venture that was not previously contracted or required.

Put-call arrangements

The joint venture agreement includes a put-call arrangement with respect to the shares of the Joint Venture held by SoftBank and its affiliates. Under certain specified circumstances and on terms specified in the joint venture agreement, including timely written notice, SoftBank has the right to cause the Company to purchase all shares of the Joint Venture held by SoftBank and its affiliates, or the put right, and the Company has a right to purchase all such shares, or the call right.

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In November 2021, the Company exercised its call right contained in the joint venture agreement with SoftBank to purchase all of the shares held by SoftBank and its affiliates in consideration for the payment of the aggregate purchase price to be determined based on an independent third-party valuation. Upon the Company's exercise of the call right in November 2021, SoftBank no longer has the option to exercise its put right. The Company and SoftBank have initiated a process to determine the independent valuation of the Joint Venture, which includes the appointment of independent appraisers by both SoftBank and the Company. As of March 31, 2022, the estimated aggregate purchase price was $78.0 million, which represented the minimum contractual purchase price and was recorded in current liabilities in the Company’s condensed consolidated balance sheet. The minimum aggregate purchase price has been calculated based on a 20% annual internal rate of return on the $41.0 million of capital invested by SoftBank in May 2018 as stipulated in the joint venture agreement up through the date the Company exercised the call right. The Company expects to complete this transaction before the end of the second quarter of 2022.

The Company may pay the purchase price for the shares of the Joint Venture in cash, in shares of its capital stock (which may be a non-voting security with senior preferences to all other classes of its equity or, if its common stock is publicly traded on a national exchange, its common stock), or in a combination thereof, based on SoftBank’s election.

Prior to November 2021, the noncontrolling interest held by SoftBank contained embedded put-call redemption features that were not solely within the Company’s control and had been classified outside of permanent equity in the consolidated balance sheets. The put-call feature embedded in the redeemable noncontrolling interest did not require bifurcation as it did not meet the definition of a derivative and was considered to be clearly and closely related to the redeemable noncontrolling interest. The Company elected to recognize the changes in redemption value immediately as they occur as if the put-call redemption feature were exercisable at the end of the reporting period. The carrying value of the redeemable noncontrolling interest was first adjusted for the earnings or losses attributable to the redeemable noncontrolling interest based on the percentage of the economic or ownership interest retained in the consolidated VIE by the noncontrolling parties, and then adjusted to equal to its redemption amount, or the fair value of the noncontrolling interest held by SoftBank, as if the redemption occurred at the end of the reporting date. The adjustment of redeemable noncontrolling interest was recorded as an adjustment to net loss attributable to Guardant Health, Inc. common stockholders in the Company's condensed consolidated statement of operations.

4.     Condensed Consolidated Balance Sheet Components

Property and Equipment, Net

Property and equipment, net consist of the following:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Machinery and equipment	$	69,583	$	63,022
Leasehold improvements	75,295		38,702
Computer hardware	21,787		16,685
Construction in progress(1)	37,104		55,873
Furniture and fixtures	7,596		3,683
Computer software	1,439		1,320
Property and equipment, gross	$	212,804	$	179,285
Less: accumulated depreciation	(61,482)		(54,824)
Property and equipment, net	$	151,322	$	124,461

(1)    As of March 31, 2022, and December 31, 2021, $16.2 million and $45.8 million of construction in progress was related to leasehold improvements, furniture and equipment for the office in Palo Alto, California, respectively. In February 2022, part of the Palo Alto office was put in service and related construction in progress was transferred to fixed assets.

Depreciation expense related to property and equipment was $6.7 million and $4.5 million for the three months ended March 31, 2022, and 2021, respectively.

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Accrued Expenses

Accrued expenses consist of the following:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Operating lease liabilities	$	16,556	$	12,856
Accrued tax liabilities	4,401		4,223
Accrued professional services	8,410		6,994
Accrued clinical studies	5,151		3,332
Accrued legal expenses	6,429		4,166
Purchases of property and equipment included in accrued expenses	1,349		5,893
Others	9,555		7,821
Total accrued expenses	$	51,851	$	45,285

5.    Fair Value Measurements, Cash Equivalents and Marketable Securities

Financial instruments consist of cash equivalents, marketable securities, accounts receivable, net, prepaid expenses and other current assets, net, accounts payable and accrued expenses. Cash equivalents and marketable securities are stated at fair value. Prepaid expenses and other current assets, net, accounts payable and accrued expenses are stated at their carrying value, which approximates fair value due to the short time to the expected receipt or payment date.

Fair value is defined as the exchange price that would be received from sale of an asset or paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. The identification of market participant assumptions provides a basis for determining what inputs are to be used for pricing each asset or liability. A financial instrument’s classification within the fair value hierarchy is based upon the lowest level of input that is significant to the fair value measurement.

A fair value hierarchy has been established which gives precedence to fair value measurements calculated using observable inputs over those using unobservable inputs. This hierarchy prioritized the inputs into three broad levels as follows:

Level 1 - Quoted prices in active markets for identical assets or liabilities.

Level 2 - Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3 - Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

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The Company’s financial assets and liabilities subject to fair value measurements on a recurring basis and the level of inputs used in such measurements were as follows:

	March 31, 2022
	Fair Value		Level 1		Level 2		Level 3
	(unaudited)
	(in thousands)
Financial Assets:
Money market funds	$	447,032	$	447,032	$	—	$	—
Total cash equivalents	$	447,032	$	447,032	$	—	$	—
U.S. government debt securities	$	388,662	$	—	$	388,662	$	—
Total short-term marketable securities	$	388,662	$	—	$	388,662	$	—
U.S. government debt securities	$	588,453	$	—	$	588,453	$	—
Total long-term marketable securities	$	588,453	$	—	$	588,453	$	—
Total	$	1,424,147	$	447,032	$	977,115	$	—
Financial Liabilities:
Contingent consideration	$	6,015	$	—	$	—	$	6,015
Total	$	6,015	$	—	$	—	$	6,015

	December 31, 2021
	Fair Value		Level 1		Level 2		Level 3
	(in thousands)
Financial Assets:
Money market funds	$	357,785	$	357,785	$	—	$	—
Total cash equivalents	$	357,785	$	357,785	$	—	$	—
U.S. government debt securities	$	440,546	$	—	$	440,546	$	—
Total short-term marketable securities	$	440,546	$	—	$	440,546	$	—
U.S. government debt securities	$	698,034	$	—	$	698,034	$	—
Total long-term marketable securities	$	698,034	$	—	$	698,034	$	—
Total	$	1,496,365	$	357,785	$	1,138,580	$	—
Financial Liabilities:
Contingent consideration	$	3,625	$	—	$	—	$	3,625
Total	$	3,625	$	—	$	—	$	3,625

The Company measures the fair value of money market funds based on quoted prices in active markets for identical securities. U.S. government debt securities are valued taking into consideration valuations obtained from third-party pricing services. The pricing services utilize industry standard valuation models, including both income and market-based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include reported trades of and broker/dealer quotes on the same or similar securities, issuer credit spreads; benchmark securities; prepayment/default projections based on historical data and other observable inputs.

There were no transfers between Level 1, Level 2 and Level 3 during the periods presented.

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Acquisition-related contingent consideration is measured at fair value on a quarterly basis and change in estimated contingent consideration to be paid are included in operating expenses in the condensed consolidated statements of operations. The fair value of acquisition-related contingent consideration is estimated using a multiple-outcome discounted cash flow valuation technique. Contingent consideration is classified within Level 3 of the fair value hierarchy, as it is based on a probability that includes significant unobservable inputs. The significant unobservable inputs include a probability-weighted estimate of achievement of certain commercialization milestones, and discount rate to present value the expected payments. A significant change in any of these input factors in isolation could have a material impact to fair value measurement. As of March 31, 2022, the Company recorded contingent consideration liability of $6.0 million, of which $4.5 million is considered long-term and was recorded within other long-term liabilities on the accompanying condensed consolidated balance sheets. As of December 31, 2021, the Company recorded contingent consideration liability of $3.6 million within other long-term liabilities on the accompanying condensed consolidated balance sheets.

As of March 31, 2022, and December 31, 2021, the fair value of the noncontrolling interest liability is considered to be a Level 3 measurement and was determined based on an annual internal rate of return of 20% on the initial amount of $41.0 million invested by SoftBank in May 2018, to the date of Company's exercising the call right in November 2021.

The following table summarizes the activities for the Level 3 financial instruments:

	Noncontrolling Interest Liability		Redeemable Noncontrolling Interest		Contingent Consideration
	Three Months Ended March 31,		Three Months Ended March 31,		Three Months Ended March 31,
	2022		2021		2022		2021
	(unaudited)
	(in thousands)
Fair value — beginning of period	$	78,000	$	57,100	$	3,625	$	1,245
Increase in fair value	—		4,287		2,390		—
Net loss for the period	—		(1,987)		—		—
Fair value — end of period	$	78,000	$	59,400	$	6,015	$	1,245

The Company considers the fair value of the Convertible Notes as of March 31, 2022, and December 31, 2021, to be a Level 2 measurement. The fair value of the Convertible Notes is primarily affected by the trading price of the Company's common stock and market interest rates. As such, the carrying value of the Convertible Notes does not reflect the market rate. See Note 7, Debt, for additional information related to the fair value of the Convertible Notes.

Cash Equivalents and Marketable Securities

The following tables summarizes the Company’s cash equivalents and marketable securities’ amortized costs, gross unrealized gains, gross unrealized losses and estimated fair values by significant investment category:

	March 31, 2022
	Amortized Cost		Gross Unrealized Gain		Gross Unrealized Loss		Estimated Fair Value
	(unaudited)
	(in thousands)
Money market fund	$	447,032	$	—	$	—	$	447,032
U.S. government debt securities	993,465		—		(16,350)		977,115
Total	$	1,440,497	$	—	$	(16,350)	$	1,424,147

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	December 31, 2021
	Amortized Cost		Gross Unrealized Gain		Gross Unrealized Loss		Estimated Fair Value
	(in thousands)
Money market fund	$	357,785	$	—	$	—	$	357,785
U.S. government debt securities	1,142,172		2		(3,594)		1,138,580
Total	$	1,499,957	$	2	$	(3,594)	$	1,496,365

There have been no material realized gains or losses on marketable securities for the periods presented. None of the Company’s investments in marketable securities has been in an unrealized loss position for more than one year. The Company determined that it did have the ability and intent to hold all marketable securities that have been in a continuous loss position until maturity or recovery and the loss position was temporary due to market volatility, thus there has been no recognition of credit losses in the three months ended March 31, 2022, and 2021, respectively. The maturities of the Company’s long-term marketable securities range from 1.0 to 1.8 years as of March 31, 2022.

6.    Intangible Assets, Net and Goodwill

The following table presents details of purchased intangible assets as of March 31, 2022, and December 31, 2021:

	March 31, 2022
	Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount		Remaining Weighted-Average Useful Life
	(unaudited)
	(in thousands)						(in years)
Intangible assets subject to amortization:
Acquired license	$	11,886	$	(2,746)	$	9,140	8.5
Non-compete agreements and other covenant rights	5,100		(2,113)		2,987		3.7
Total intangible assets subject to amortization	16,986		(4,859)		12,127
Intangible assets not subject to amortization:
IPR&D	1,600		—		1,600
Goodwill	3,290		—		3,290
Total purchased intangible assets	$	21,876	$	(4,859)	$	17,017

	December 31, 2021
	Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount		Remaining Weighted-Average Useful Life
	(in thousands)						(in years)
Intangible assets subject to amortization:
Acquired license	$	11,886	$	(2,473)	$	9,413	8.8
Non-compete agreements and other covenant rights	5,100		(1,906)		3,194		3.9
Total intangible assets subject to amortization	16,986		(4,379)		12,607
Intangible assets not subject to amortization:
IPR&D	1,600		—		1,600
Goodwill	3,290		—		3,290
Total purchased intangible assets	$	21,876	$	(4,379)	$	17,497

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Amortization of finite-lived intangible assets was $0.5 million and $0.5 million for the three months ended March 31, 2022, and 2021, respectively.

The following table summarizes estimated future amortization expense of finite-lived intangible assets, net:

Year Ending December 31,
	(unaudited)
	(in thousands)
Remainder of 2022	$	1,467
2023	1,947
2024	1,953
2025	1,670
2026	1,212
2027 and thereafter	3,878
Total	$	12,127

7. Debt

Convertible Senior Notes

In November 2020, the Company issued $1.15 billion principal amount of its 0% Convertible Senior Notes due 2027, or the 2027 Notes. The 2027 Notes do not bear interest, and the principal amount of the Notes will not accrete. However, special interest and additional interest may accrue on the 2027 Notes at a rate per annum not exceeding 0.50% (subject to certain exceptions) upon the occurrence of certain events such as the failure to file certain reports to the Securities and Exchange Commission, or to remove certain restrictive legends from the Notes. The Notes will mature on November 15, 2027, unless repurchased, redeemed or converted earlier.

Before August 15, 2027, holders of the 2027 Notes will have the right to convert their 2027 Notes only under the following circumstances:

•during any calendar quarter (and only during such calendar quarter) commencing after the calendar quarter ending on March 31, 2021, if the last reported sale price of the Company's common stock exceeds 130% of the conversion price for each of at least 20 trading days (whether or not consecutive) during the 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter, or the sale price condition;

•during the five consecutive business days immediately after any ten consecutive trading day period, or the measurement period, if the trading price per $1,000 principal amount of the Notes for each trading day of the measurement period is less than 98% of the product of the last reported sale price of the Company's common stock on such trading day and the conversion rate on such trading day; or

•upon the occurrence of specified corporate events

From and after August 15, 2027, holders of the 2027 Notes may convert their 2027 Notes at any time at their election until the close of business on the second scheduled trading day immediately before the maturity date.

The Company will settle conversions by paying or delivering, as applicable, cash, shares of its common stock or a combination of cash and shares of its common stock, at the Company’s election.

The initial conversion rate is 7.1523 shares of common stock per $1,000 principal amount of 2027 Notes, which represents an initial conversion price of approximately $139.82 per share of common stock. The conversion rate and conversion price will be subject to customary adjustments upon the occurrence of certain events. In addition, if certain corporate events that constitute a “Make-Whole Fundamental Change” occur, then the conversion rate will, in certain circumstances, be increased for a specified period of time.

The Company may not redeem the 2027 Notes at its option at any time before November 20, 2024. The Notes will be redeemable, in whole or in part, at the Company’s option at any time, and from time to time, on or after November 20, 2024 and on or before the 25th scheduled trading day immediately before the maturity date, at a cash redemption price equal to the principal amount of the Notes to be redeemed, plus accrued and unpaid special interest and additional interest, if any, to, but excluding, the redemption date, but only if the last reported sale price per share of the Company’s common stock exceeds 130% of the conversion price on (i) each of at least 20 trading days,

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whether or not consecutive, during the 30 consecutive trading days ending on, and including, the trading day immediately before the date the Company sends the related redemption notice; and (ii) the trading day immediately before the date the Company sends such notice. In addition, calling any Note for redemption will constitute a Make-Whole Fundamental Change with respect to that Note, in which case the conversion rate applicable to the conversion of that Note will be increased in certain circumstances if it is converted after it is called for redemption.

If certain corporate events that constitute a “Fundamental Change” occur, then, subject to a limited exception for certain cash mergers, holders of Notes may require the Company to repurchase their 2027 Notes at a cash repurchase price equal to the principal amount of the 2027 Notes to be repurchased, plus accrued and unpaid special interest and additional interest, if any, to, but excluding, the fundamental change repurchase date. The definition of Fundamental Change includes certain business combination transactions involving the Company and certain de-listing events with respect to the Company’s common stock.

Since the 2027 Notes were not convertible as of March 31, 2022, the net carrying amount of the 2027 Notes was classified as a long-term liability.

The following table sets forth the net carrying amounts of the 2027 Notes as of March 31, 2022, and December 31, 2021:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Liability component:
Principal	$	1,150,000	$	1,150,000
Less: debt issuance costs, net of amortization	(14,537)		(15,179)
Net carrying amount	$	1,135,463	$	1,134,821

The total estimated fair value of the 2027 Notes was $0.9 billion and $1.2 billion as of March 31, 2022, and December 31, 2021, respectively. The fair value was determined based on the closing trading price per $100 of the 2027 Notes as of the last day of trading for the period.

The interest expense recognized in relation to amortization of debt issuance costs was $0.6 million and $0.6 million for the three months ended March 31, 2022, and 2021, respectively, which represented an effective interest rate of 0.2% and 0.2% for the three months ended March 31, 2022, and 2021, respectively.

Note Hedges

To minimize the impact of potential economic dilution upon conversion of the 2027 Notes, the Company entered into convertible note hedge transactions, or the 2027 Note Hedges, with respect to its common stock concurrent with the issuance of the Notes. The 2027 Note Hedges cover, subject to customary adjustments, the number of shares of common stock initially underlying the Notes. The strike price of the 2027 Note Hedges will initially be approximately $182.60 per share, which represents a premium of 75% over the last reported sale price of the Company’s common stock of $104.34 per share on November 16, 2020, and is subject to certain adjustments under the terms of the 2027 Note Hedges.

The 2027 Note Hedges will expire upon maturity of the 2027 Notes. The 2027 Note Hedges are separate transactions and are not part of the terms of the 2027 Notes. Holders of the 2027 Notes will not have any rights with respect to the 2027 Note Hedges. The shares receivable related to the 2027 Note Hedges are excluded from the calculation of diluted earnings per share as they are anti-dilutive.

As these transactions meet certain accounting criteria, the 2027 Note Hedges are recorded in stockholders’ equity and are not accounted for as derivatives. The Company paid an aggregate amount of $90.0 million for the 2027 Note Hedges, which has been recorded as a reduction to additional paid-in capital and will not be remeasured.

8. Leases

The Company has entered into various operating lease agreements for office space, data center, lab and warehouse use, with remaining terms ranging from 1 year to 12 years some of which include one or more options to renew. As leases approach maturity, the Company considers various factors such as market conditions and the terms of any renewal options that may exist to determine whether it will renew the lease, as such, the Company does not include renewal options in its lease terms for calculating its lease liability, as the renewal options allow it to maintain

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operational flexibility and the Company is not reasonably certain it will exercise these renewal options at the time of the lease commencement. In July 2020, the Company entered into two lease agreements for additional office space in Palo Alto, California, or the Palo Alto Lease, and in San Diego, California, or the San Diego Lease. The San Diego Lease has a term of 8 years with rent payments commencing in May 2022. The Palo Alto Lease has a term of 12 years with an option to renew the lease term for an additional ten years which has not been considered in the determination of ROU or the lease liability as the Company does not consider it reasonably certain of exercising the renewal option. After the initial payment of $0.9 million in February 2022, the remaining rent payments for the Palo Alto Lease will commence in June 2022. Both leases consist of fixed and variable payments and are being accounting for as operating leases. The Company took possession of these facilities in March 2021. The Company estimated the incremental borrowing rate to determine the present value of lease payments for the San Diego and Palo Alto leases using trading data of the Company's convertible debt adjusted for credit rating and market yield curves.

Operating lease expense was $6.9 million and $3.9 million for the three months ended March 31, 2022, and 2021, respectively, which includes both lease and non-lease components (primarily common area maintenance charges and property taxes).

	March 31, 2022		December 31, 2021
	(unaudited)
Weighted-average remaining lease term (in years)	9.7		10.0
Weighted-average discount rate	4.02	%	4.01	%

The following table summarizes the Company's future principal contractual obligations for operating lease commitments as of March 31, 2022:

Year Ending December 31,
	(unaudited)
	(in thousands)
Remainder of 2022	$	17,030
2023	30,363
2024	32,891
2025	32,238
2026	27,753
2027 and thereafter	149,637
Total operating lease payments	$	289,912
Less: imputed interest	(47,979)
Total operating lease liabilities	$	241,933

Finance leases are not material to the Company's condensed consolidated financial statements.

9.    Commitments and Contingencies

Legal Proceedings

In addition to commitments and obligations incurred in the ordinary course of business, from time to time the Company may be subject to a variety of claims and legal proceedings, including claims from customers and vendors, pending and potential legal actions for damages, governmental investigations and other matters. For example, the Company has received, and may in the future continue to receive letters, claims or complaints from others alleging false advertising, patent infringement, violation of employment practices and trademark infringement. The Company has also instituted, and may in the future institute, additional legal proceedings to enforce its rights and seek remedies, such as monetary damages, injunctive relief and declaratory relief. The Company cannot predict the results of any such disputes, and despite the potential outcomes, the existence thereof may have an adverse material impact on the Company because of diversion of management time and attention as well as the financial costs related to resolving such disputes.

The Company and its affiliates are parties to the legal claims and proceedings described below. The Company is vigorously defending itself against those claims and in those proceedings. Significant developments in those matters

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are described below. If the Company is unsuccessful in defending, or if it determines to settle, any of these matters, it may be required to pay substantial sums, be subject to injunction and/or be forced to change how it operates its business, which could have a material adverse impact on its financial position or results of operations.

Unless otherwise stated, the Company is unable to reasonably estimate the loss or a range of possible loss for the matters described below. Often, it is not reasonably possible for the Company to determine that a loss is probable for a claim, or to reasonably estimate the amount of loss or a range of loss, because of the limited information available and the potential effects of future events and decisions by third parties, such as courts and regulators, that will determine the ultimate resolution of the claim. Many of the matters described are at preliminary stages, raise novel theories of liability or seek an indeterminate amount of damages. It is not uncommon for claims to be resolved over a number of years. The Company reviews loss contingencies at least quarterly to determine whether the loss probability has changed and whether it can make a reasonable estimate of the possible loss or range of loss. When the Company determines that a loss from a claim is probable and reasonably estimable, it records a liability in the amount of its estimate for the ultimate loss. The Company also provides disclosure when it is reasonably possible that a loss may be incurred or when it is reasonably possible that the amount of a loss will exceed its recorded liability.

Intellectual Property Disputes

In August 2021, TwinStrand Biosciences, Inc., or TwinStrand Biosciences, and the University of Washington filed a patent infringement suit in the United States District Court for the District of Delaware alleging that the Company infringes U.S. Patent Nos. 10,287,631; 10,689,699; 10,752,951; and 10,760,127. The Company answered the complaint in October 2021, denying TwinStrand Biosciences’ allegations and asserted counterclaims of invalidity, unenforceability due to inequitable conduct and infringement of four of the Company’s patents. Discovery in the case is ongoing and trial is scheduled to commence in November 2023.

In March 2022, Illumina Inc., or Illumina, filed suit in the United States District Court for the District of Delaware against the Company and its Co-Chief Executive Officers, Dr. Helmy Eltoukhy, or Dr. Eltoukhy, and Dr. AmirAli Talasaz, or Dr. Talasaz, or collectively the Defendants, alleging that Illumina is the owner of certain of the Company’s patents and patent applications, and that the Defendants allegedly misappropriated Illumina trade secrets. Illumina also alleges that Drs. Eltoukhy and Talasaz breached various Illumina employment contracts, company policies, and implied covenants of good faith and fair dealing as part of their former employment with Illumina prior to starting the Company. Illumina is requesting unspecified compensatory and punitive damages, attorneys’ fees, and specific performance in the form of a declaration of ownership and assignment of intellectual property filed for or obtained by the Defendants that derives from the alleged misuse of Illumina confidential information. The Defendants deny the allegations of misconduct. The court has not yet entered a scheduling order.

False Advertising Dispute

In May 2021, the Company also filed a lawsuit against Natera, Inc., or Natera, in the United States District Court for the Northern District of California, wherein the Company alleged that Natera is misleading healthcare providers about the performance of the Company’s new oncology test, Guardant Reveal, by suggesting the test is inaccurate and/or insensitive, and inferior to Natera’s Signatera assay. The Company is seeking an injunction to prevent Natera from continuing to make false and misleading statements and to require Natera to take corrective actions. Natera has asserted counterclaims of false and misleading statements, false advertising, unlawful trade practices and unfair competition. The Company moved to dismiss Natera’s counterclaims, and in January 2022, the court granted in part and denied in part the Company's motion to dismiss. Discovery is ongoing and trial is scheduled to commence in February 2023.

Civil Investigative Demand

In January 2022, the Company received a Civil Investigative Demand, or CID, from the United States Attorney for the Northern District of California in connection with an investigation under the False Claims Act. The CID requests information and documents regarding billing of government-funded programs for the Company’s panel of genetic tests known as Guardant360. The Company is fully cooperating with the investigation. At this time, the Company is unable to predict the outcome of this investigation.

10.    Common Stock

The Company’s common stockholders are entitled to dividends if and when declared by the Company’s Board of Directors, or the Board of Directors. As of March 31, 2022, and December 31, 2021, no dividends on the Company's common stock had been declared by the Board of Directors.

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The Company’s common stock has been reserved for the following potential future issuances:

	March 31, 2022	December 31, 2021
	(unaudited)
Shares underlying outstanding stock options	2,509,506	2,624,974
Shares underlying unvested restricted stock units	1,506,378	1,498,553
Market-based restricted stock units	2,260,764	2,260,764
Performance-based restricted stock units	345,082	374,596
Shares available for issuance under the 2018 Incentive Award Plan	8,925,158	5,231,624
Shares available for issuance under the 2018 Employee Stock Purchase Plan	1,426,264	1,426,264
Total	16,973,152	13,416,775

11.    Stock-Based Compensation

Stock Option Activity

A summary of the Company’s stock option activity under the 2012 Stock Plan (as amended and restated), or the 2012 Plan, and the 2018 Incentive Award Plan, or the 2018 Plan, and related information is as follows:

		Options Outstanding
	Shares Available for Grant	Shares Subject to Options Outstanding	Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (Years)	Aggregate Intrinsic Value
	(unaudited)
						(in thousands)
Balance as of January 1, 2022	5,231,624	2,624,974	$	29.17	6.5	$	193,014
2018 Plan annual increase(1)	3,689,000	—
Granted	(7,252)	7,252	62.10
Exercised	—	(105,218)	5.94
Canceled	13,268	(17,502)	74.71
Restricted stock units granted	(128,855)	—	—
Restricted stock units canceled	97,859	—	—
Performance-based restricted stock units canceled	29,514	—	—
Balance as of March 31, 2022	8,925,158	2,509,506	$	29.92	6.3	$	115,462
Vested and Exercisable as of March 31, 2022		1,957,910	$	12.56	5.6	$	109,604

(1)Effective as of January 1, 2022, an additional 3,689,000 shares of common stock became available for issuance under the 2018 Plan, as a result of the operation of an automatic annual increase provision therein.

Aggregate intrinsic value represents the difference between the estimated fair value of the underlying common stock and the exercise price of outstanding, in-the-money options. The total intrinsic value of the options exercised was $7.3 million and $38.3 million for the three months ended March 31, 2022, and 2021, respectively.

The weighted-average grant date fair value of options granted was $36.32 and $101.21 per share for the three months ended March 31, 2022, and 2021, respectively.

Future stock-based compensation for unvested options as of March 31, 2022 was $27.9 million, which is expected to be recognized over a weighted-average period of 2.9 years.

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Restricted Stock Units

A summary of the Company’s restricted stock unit activity excluding the performance-based and market-based restricted stock units under the 2012 Plan and the 2018 Plan and related information is as follows:

	Restricted Stock Units Outstanding	Weighted-Average Grant Date Fair Value
	(unaudited)
Balance as of January 1, 2022	1,498,553	$	109.72
Granted	128,855	62.10
Vested and released	(23,171)	105.58
Canceled	(97,859)	108.53
Balance as of March 31, 2022	1,506,378	$	105.78

Future stock-based compensation for unvested restricted stock units as of March 31, 2022 was $130.1 million, which is expected to be recognized over a weighted-average period of 3.0 years.

Performance-based Restricted Stock Units

Since November 2020, the Compensation Committee of the Board of Directors started to approve, and the Company started to grant performance-based restricted stock units, or PSUs, under the 2018 Plan. The PSUs granted to employees consist of financial and operational metrics to be met over a performance period of 4 years and an additional service period requirement of six months after the performance metrics are met. The PSUs granted to a consultant consistent of operational metrics to be met over a performance period of 4 years. The PSUs are expected to be expensed over a period of approximately 4 years to 4.5 years subject to meeting the respective performance metrics and service requirements. As of March 31, 2022, a significant portion of these PSUs are not expected to achieve the related performance metrics, and therefore, no stock-based compensation expense was recorded for the PSUs that were not probable to vest.

A summary of the Company’s performance-based restricted stock unit activity under the 2018 Plan and related information is as follows:

	Performance-based Restricted Stock Units Outstanding	Weighted-Average Grant Date Fair Value
	(unaudited)
Balance as of January 1, 2022	374,596	$	116.58
Canceled	(29,514)	113.40
Balance as of March 31, 2022	345,082	$	116.86

Stock-based compensation recorded for the PSUs was $0.3 million and $0.3 million for the three months ended March 31, 2022, and 2021, respectively. Future stock-based compensation for unvested PSUs that are probable to vest as of March 31, 2022 was $3.5 million, which is expected to be recognized over a weighted-average period of 2.9 years.

Market-based Restricted Stock Units

In May 2020, the Board of Directors approved and granted 1,695,574 market-based restricted stock units, or MSUs, under the 2018 Plan to each of the Company's Co-Chief Executive Officers, which is subject to the achievement of market-based share price goals established by the Board of Directors. The MSUs consist of three separate tranches and the vesting of each tranche is subject to the Company's common stock closing price being maintained at or above a predetermined share price goal for a period of 30 consecutive calendar days. The share price goal can be met any time during the seven-year performance period from the date of grant. Upon vesting, the MSUs must be held for a period of six to twelve months depending on the time of vesting within the seven-year performance period. The vesting of the MSUs can also be triggered upon a change in control event and achievement of a certain change in

29

control price goal, or when there is a qualifying termination or in the event of death or disability. The following table presents additional information relating to each MSU award:

Tranche	Price Goal	Number of RSUs
Tranche 1	$120 per share	565,192
Tranche 2	$150 per share	565,191
Tranche 3	$200 per share	565,191

The grant date fair values of the MSUs were determined using a Monte Carlo valuation model for each tranche. The related stock-based compensation expense for each tranche is recognized based on an accelerated attribution method over the estimated derived service period. If the related share price goal is achieved earlier than its expected derived service period, the stock-based compensation expense will be recognized as a cumulative catch-up expense from the grant date to that point in time in achieving the share price goal. The derived service period is the median duration of the successful stock price paths to meet the price goal for each tranche as simulated in the Monte Carlo valuation model. The Monte Carlo valuation model uses assumptions such as volatility, risk-free interest rate, cost of equity and dividend estimated for the performance period of the MSU. The weighted-average grant date fair value of the MSUs was $67.00 per share and the weighted-average derived service period was estimated to be in the range of 0.83 – 2.07 years.

On January 1, 2021, Tranche 1 of the MSUs became vested because it had met both service requirement and market-based performance metrics as the predetermined share price goal of $120 per share was achieved for a period of 30 consecutive calendar days. As of March 31, 2022 and December 31, 2021, 2,260,764 shares of market-based restricted stock units, with a weighted-average grant date fair value of $65.20 per share, were outstanding under the 2018 Plan. No MSUs were granted, vested or canceled during the three months ended March 31, 2022.

Stock-based compensation for the MSUs was $8.5 million and $43.9 million, for the three months ended March 31, 2022, and 2021, respectively, which was recorded in general and administrative expenses on the Company's condensed consolidated statement of operations. Future stock-based compensation for unvested MSUs as of March 31, 2022 was $7.6 million, which is expected to be recognized over a weighted-average period of 0.2 years. In the event of a change in control, a qualifying termination, death, disability or the share price goal occurring earlier than the estimated derived service period, the stock-based compensation relating to these MSUs could be accelerated. Any MSUs that remain unvested at the end of the seven-year performance period will automatically be forfeited and terminated without further consideration.

AMEA 2020 Equity Incentive Plan

In August 2020, the board of directors of the Joint Venture approved its 2020 Equity Incentive Plan, or the AMEA 2020 Plan, under which the Joint Venture may grant equity incentive awards such as stock options, restricted stock, restricted stock units, stock appreciation rights and cash-based awards to its employees and non-employees. Stock options granted may be either incentive stock options or nonstatutory stock options. Incentive stock options may be granted only to employees of the Joint Venture or its affiliates. Nonstatutory stock options may be granted to employees, directors and non-employee consultants. Stock options may be granted at an exercise price of not less than the fair market value of the Joint Venture's common stock on the date of grant, determined by the board of directors of the Joint Venture. Options generally vest over 4 years and expire as determined by the board of directors of the Joint Venture, provided that the term of options may not exceed 10 years from the date of grant. For individuals holding more than 10% of the total combined voting power of all classes of stock of the Joint Venture, the exercise price of an option will not be less than 110% of the fair market value of the Joint Venture's common stock on the date of grant, and the term of the option will not exceed 5 years. A total of 4,595,555 shares of the Joint

30

Venture's Class B common stock are initially reserved for issuance under the AMEA 2020 Plan, and the number of shares may be increased in accordance with the terms of the AMEA 2020 Plan.

A summary of the Joint Venture's stock option activity under the AMEA 2020 Plan and related information is as follows:

		Options Outstanding
	Shares Available for Grant	Shares Subject to Options Outstanding	Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (Years)	Aggregate Intrinsic Value
	(unaudited)
						(in thousands)
Balance as of January 1, 2022	340,928	3,652,219	$	0.58	8.8	$	—
Exercised	—	(582,020)	0.58
Canceled	74,999	(74,999)	0.58
Balance as of March 31, 2022	415,927	2,995,200	$	0.58	8.6	$	—
Vested and Exercisable as of March 31, 2022		1,809,430	$	0.58	8.4	$	—

No stock options were granted under the AMEA 2020 Plan for the three months ended March 31, 2022. The weighted-average grant date fair value of options granted under the AMEA 2020 Plan was $0.33 per share for the three months ended March 31, 2021. Future stock-based compensation for unvested options as of March 31, 2022 was $0.3 million, which is expected to be recognized over a weighted-average period of 2.4 years.

Stock-Based Compensation Expense

The following table presents the effect of employee and non-employee related stock-based compensation expense including the Joint Venture:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
Cost of precision oncology testing	$	1,164	$	767
Research and development expense	5,343		4,300
Sales and marketing expense	5,525		2,880
General and administrative expense	12,767		47,122
Total stock-based compensation expense	$	24,799	$	55,069

Valuation of Stock Options

The grant date fair value of stock options was estimated using a Black-Scholes option-pricing model with the following weighted-average assumptions including the Joint Venture:

	Three Months Ended March 31,
	2022	2021
	(unaudited)
Expected term (in years)	5.97	6.01 – 6.04
Expected volatility	63.3%	63.6% – 66.4%
Risk-free interest rate	1.9%	0.3% – 0.8%
Expected dividend yield	—%	—%

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The determination of the fair value of stock options on the date of grant using a Black-Scholes option-pricing model is affected by the estimated fair value of common stock of the Company and the Joint Venture, as well as assumptions regarding a number of variables that are complex, subjective and generally require significant judgment to determine. The valuation assumptions were determined as follows:

Fair Value of Common Stock

The fair value of the Company’s common stock is determined by the closing price, on the date of grant, of its common stock, which is traded on the Nasdaq Global Select Market. The grant date fair value of the Joint Venture's common stock has been determined by the board of directors of the Joint Venture. The grant date fair value of the Joint Venture’s common stock was determined using valuation methodologies which utilize certain assumptions including probability weighting of events, volatility, time to liquidation, a risk-free interest rate and an assumption for a discount for lack of marketability. In determining the fair value of the Joint Venture’s common stock, the methodologies used to estimate the enterprise value of the Joint Venture were performed using methodologies, approaches, and assumptions consistent with the American Institute of Certified Public Accountants Accounting and Valuation Guide, Valuation of Privately-Held-Company Equity Securities Issued as Compensation.

Expected Term

The expected term represents the period that the options granted are expected to be outstanding and is determined using the simplified method (based on the mid-point between the vesting date and the end of the contractual term) as the Company has concluded that its stock option exercise history does not provide a reasonable basis upon which to estimate expected term.

Expected Volatility

Prior to the commencement of trading of the Company’s common stock on the Nasdaq Global Select Market on October 4, 2018 in connection with the IPO, there was no active trading market for the Company's common stock. Due to limited historical data for the trading of the Company’s common stock, expected volatility is estimated based on the average volatility for comparable publicly traded peer group companies in the same industry plus the Company's expected volatility for the available periods. The comparable companies are chosen based on their similar size, stage in the life cycle or area of specialty.

The Joint Venture derived the expected volatility from the average historical volatility over a period approximately equal to the expected term of comparable publicly traded companies within its peer group that were deemed to be representative of future stock price trends as the Joint Venture does not have any trading history for its common stock. The Joint Venture will continue to apply this process until a sufficient amount of historical information regarding the volatility of its own stock price becomes available.

Risk-Free Interest Rate

The risk-free interest rate is based on the U.S. Treasury rate, with maturities similar to the expected term of the stock options.

Expected Dividend Yield

The Company and the Joint Venture does not anticipate paying any dividends in the foreseeable future and, therefore, uses an expected dividend yield of zero.

2018 Employee Stock Purchase Plan

In September 2018, the Company’s Board of Directors adopted and its stockholders approved the 2018 Employee Stock Purchase Plan, or the ESPP. A total of 922,250 shares of common stock were initially reserved for issuance under the ESPP. Effective as of January 1, 2020, an additional 942,614 shares of common stock became available for issuance under the ESPP.

Subject to any plan limitations, the ESPP allows eligible employees to contribute, normally through payroll deductions, up to 10% of their earnings for the purchase of the Company’s common stock at a discounted price per share. The price at which common stock is purchased under the ESPP is equal to 85% of the fair market value of the Company’s common stock on the first or last day of the offering period, whichever is lower. The ESPP provides for separate six-month offering periods beginning on May 15 and November 15 of each year.

No ESPP shares were granted or purchased for the three months ended March 31, 2022 and 2021. The total compensation expense related to the ESPP was $1.0 million and $0.8 million for the three months ended March 31, 2022, and 2021, respectively.

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The fair value of the stock purchase right granted under the ESPP was estimated on the first day of each offering period using the Black-Scholes option pricing model. The valuation assumptions used were substantially consistent with the assumption used to value stock options with the exception of the expected term which was based on the term of each purchase period.

As of March 31, 2022, the unrecognized stock-based compensation expense related to the ESPP was $0.5 million, which is expected to be recognized over the remaining term of the offering period of 0.1 years.

12.    Net Loss Per Share Attributable to Guardant Health, Inc. Common Stockholders

The following table sets forth the computation of the basic and diluted net loss per share attributable to Guardant Health, Inc. common stockholders:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands, except per share data)
Net loss	$	(123,228)	$	(107,358)
Adjustment of redeemable noncontrolling interest	—		(2,300)
Net loss attributable to Guardant Health, Inc. common stockholders, basic and diluted	$	(123,228)	$	(109,658)
Net loss per share attributable to Guardant Health, Inc. common stockholders, basic and diluted	$	(1.21)	$	(1.09)
Weighted-average shares used in computing net loss per share attributable to Guardant Health, Inc. common stockholders, basic and diluted	101,853		100,955

Since the Company was in a loss position for all periods presented, basic net loss per share attributable to Guardant Health, Inc. common stockholders is the same as diluted net loss per share attributable to Guardant Health, Inc. common stockholders, as the inclusion of all potential shares of common stock outstanding would have been anti-dilutive. The following weighted-average common stock equivalents were excluded from the calculation of diluted net loss per share attributable to Guardant Health, Inc. common stockholders for the periods presented as they had an anti-dilutive effect:

	Three Months Ended March 31,
	2022	2021
	(unaudited)
	(in thousands)
Stock options issued and outstanding (1)	2,550	2,912
Restricted stock units	1,484	1,120
MSUs	2,261	2,646
PSUs	357	407
ESPP obligation	84	47
Common stock subject to repurchase	—	11
Convertible senior notes	8,225	8,225
Total	14,961	15,368

(1)    Excludes outstanding stock options to purchase 2,995,200 shares of the Joint Venture's Class B common stock under the AMEA 2020 Plan as of March 31, 2022.

13.    Income Taxes

The income tax expense for the three months ended March 31, 2022 was determined based upon estimates of the Company’s effective income tax rates in various jurisdictions. The difference between the Company’s effective income tax rate and the U.S. federal statutory rate is primarily attributable to state income taxes, foreign income taxes, the effect of certain permanent differences, and full valuation allowance against net deferred tax assets.

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The income tax expense for the three months ended March 31, 2022, and 2021, relates primarily to state minimum income tax and income tax on the Company’s earnings in foreign jurisdictions.

14.    Segment and Geographic Information

The Company operates as one operating segment. The Company's chief operating decision makers are its Co-Chief Executive Officers, who review financial information presented on a consolidated basis for the purposes of making operating decisions, assessing financial performance and allocating resources.

The following table sets forth the Company’s revenue by geographic areas based on the customers’ locations:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
United States	$	90,871	$	72,300
International (1)	5,228		6,365
Total revenue	$	96,099	$	78,665

(1)    No single country outside of the United States accounted for more than 10% of total revenue during the three months ended March 31, 2022, and 2021, respectively.

As of March 31, 2022, and December 31, 2021, 98% and 98%, respectively, of the Company’s long-lived assets and right-of-use assets are located in the United States.

15.    Related Party Transactions

As discussed in Note 3, Investment in Joint Venture, the Company and an affiliate of SoftBank formed and capitalized the Joint Venture to accelerate commercialization of its products in Asia, the Middle East and Africa. The Company has consolidated the financial position, results of operations and cash flows of the Joint Venture in its financial statements and all intercompany balances have been eliminated in consolidation.

The Company and its subsidiaries may, in the ordinary course of business, have transactions with unaffiliated companies of which certain of the Company’s directors are directors and/or executive officers. The Company believes that such transactions are on the same terms generally offered by such other companies to other entities in comparable transactions. The Company does not consider the amounts involved in such transactions to be material in relation to its businesses, the businesses of such other companies or the interests of the directors involved.

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

You should read the following discussion and analysis of our financial condition and results of operations together with the unaudited condensed consolidated financial statements and related notes included elsewhere in this Quarterly Report on Form 10-Q. This discussion and other parts of this Quarterly Report on Form 10-Q contain forward-looking statements that involve risk and uncertainties, such as statements of our plans, objectives, beliefs, expectations and intentions. Our actual results could differ materially from those discussed in these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed in Part I, Item 1A, “Risk Factors,” of our Annual Report on Form 10-K for the year ended December 31, 2021 and in Part II, Item 1A, “Risk Factors” of this Quarterly Report on Form 10-Q.

Overview

We are a leading precision oncology company focused on helping conquer cancer globally through use of our proprietary tests, vast data sets and advanced analytics. Today our proprietary tests are helping to realize the full potential of precision oncology by providing patients and their doctors critical insights that can inform decisions at all stages of the disease, from detecting early signs of cancer, to monitoring cancer recurrence, to guiding treatment decisions. We believe that the key to conquering cancer is unprecedented access to its molecular information throughout all stages of the disease, which we intend to enable by our tests. By looking at the unique dimensions of cancer found in blood, including genomic alterations, methylation, and fragmentomics, we are unlocking insights that can increasingly help patients across all stages of cancer, including at its earliest, when it’s most treatable. We provide our Guardant360 LDT, Guardant360 CDx and GuardantOMNI blood-based tests and Guardant360 TissueNext tissue-based tests for advanced stage cancer, Guardant Reveal blood-based tests to detect residual and recurring disease in Stage II-III colorectal cancer patients, and Guardant360 Response blood-based tests to predict patient response to immunotherapy or targeted therapy 8 weeks earlier than current standard-of-care imaging. Our Guardant360 CDx test was the first comprehensive liquid biopsy test approved by the U.S. Food and Drug Administration, or the FDA, to provide tumor mutation profiling with solid tumors and to be used as a companion diagnostic in connection with non-small cell lung cancer, or NSCLC. In April 2022, we presented new data from our broad portfolio of blood tests at the American Association for Cancer Research Annual Meeting which demonstrated the ability of our investigational next-generation Guardant SHIELD multi-cancer assay to accurately detect early-stage cancers and identify the tumor tissue of origin with high accuracy. To help identify cancer at the earliest stages, in May 2022, we launched Shield LDT, a blood-based test to detect early signs of colorectal cancer in average-risk adults age 45 and older who show no symptoms and are not up to date with recommended screening guidelines. From a simple blood draw, the test uses a novel multimodal approach to detect colorectal cancer signals in the bloodstream, including DNA that is shed by tumors. Using data collected from our tests, we have also developed our GuardantINFORM platform to further accelerate precision oncology drug development by biopharmaceutical companies by offering them an in-silico research platform to unlock further insights into tumor evolution and treatment resistance across various biomarker-driven cancers.

We currently perform our tests in our clinical laboratory located in Redwood City, California. Our Redwood City laboratory is certified pursuant to the Clinical Laboratory Improvement Amendments of 1988, or CLIA, accredited by the College of American Pathologists, or CAP, permitted by the New York State Department of Health, or NYSDOH, and licensed in California and four other states. Our San Diego laboratory is CLIA-certified, and we expect to commence testing in the San Diego laboratory by the end of June 2022, upon receipt of CAP accreditation for research and limited clinical purposes. In February 2022, we received CAP accreditation for our laboratory in Japan where we expect to commence processing samples following receipt of additional certification for processing In Vitro Diagnostic, or IVD, samples and reimbursement approval.

We generated total revenue of $96.1 million and $78.7 million for the three months ended March 31, 2022, and 2021, respectively. We also incurred net losses of $123.2 million and $107.4 million for the three months ended March 31, 2022, and 2021, respectively. We have funded our operations to date principally from the sale of our stock, convertible senior notes, and revenue from our precision oncology testing and development services and other. As of March 31, 2022, we had cash, cash equivalents and marketable securities of approximately $1.6 billion.

Factors affecting our performance

We believe there are several important factors that have impacted and that we expect will impact our operating performance and results of operations, including:

•Testing volume, pricing and customer mix. Our revenue and costs are affected by the volume of testing and mix of customers from period to period. We evaluate both the volume of tests that we perform for patients on behalf of clinicians and the number of tests we perform for biopharmaceutical companies. Our performance

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depends on our ability to retain and broaden adoption with existing customers, as well as attract new customers. We believe that the test volume we receive from clinicians and biopharmaceutical companies are indicators of growth in each of these customer verticals. Customer mix for our tests has the potential to significantly affect our results of operations, as the average selling price for biopharmaceutical sample testing is currently higher than our average reimbursement for clinical tests because we are not a contracted provider for, or our tests are not covered by clinical patients’ insurance for, the majority of the tests that we perform for patients on behalf of clinicians. Revenue from clinical tests for patients covered by Medicare represented approximately 44% and 39% of our precision oncology revenue from clinical customers during the three months ended March 31, 2022, and 2021, respectively.

•Payer coverage and reimbursement. Our revenue depends on achieving broad coverage and reimbursement for our tests from third-party payers, including both commercial and government payers. Precision oncology revenue from tests for clinical customers is calculated based on our expected cash collections, using the estimated variable consideration. The variable consideration is estimated based on historical collection patterns as well as the potential for changes in future reimbursement behavior by one or more payers. Estimation of the impact of the potential for changes in reimbursement requires significant judgment and considers payers' past patterns of changes in reimbursement as well as any stated plans to implement changes. Any cash collections over the expected reimbursement period exceeding the estimated variable consideration are recorded in future periods based on actual cash received. Payment from commercial payers can vary depending on whether we have entered into a contract with the payers as a “participating provider” or do not have a contract and are considered a “non-participating provider”. Payers often reimburse non-participating providers, if at all, at a lower amount than participating providers. Because we are not contracted with these payers, they determine the amount that they are willing to reimburse us for any of our tests and they can prospectively and retrospectively adjust the amount of reimbursement, adding to the complexity in estimating the variable consideration. When we contract with a payer to serve as a participating provider, reimbursements by the payer are generally made pursuant to a negotiated fee schedule and are limited to only covered indications or where prior approval has been obtained. Becoming a participating provider can result in higher reimbursement amounts for covered uses of our tests and, potentially, no reimbursement for non-covered uses identified under the payer’s policies or the contract. As a result, the potential for more favorable reimbursement associated with becoming a participating provider may be offset by a potential loss of reimbursement for non-covered uses of our tests. Current Procedural Terminology, or CPT, coding plays a significant role in how our tests are reimbursed both from commercial and governmental payers. In addition, Z-Code Identifiers are used by certain payers, including under Medicare's Molecular Diagnostic Services Program, or MolDx, to supplement CPT codes for our molecular diagnostics tests. Changes to the codes used to report to payers may result in significant changes in its reimbursement. If their policies were to change in the future to cover additional cancer indications, we anticipate that our total reimbursement would increase. In January 2021, a proprietary laboratory analyses, or PLA code was issued for our Guardant360 CDx with an effective date in April 2021. Additionally, based on this new PLA code, we applied to the Centers for Medicare and Medicaid Services or CMS for our Guardant360 CDx test to become an advanced diagnostic laboratory test, or ADLT. In March 2021, CMS approved ADLT status to the Guardant360 CDx test, based on which Medicare paid us at the lowest available commercial rate per test, from April 1, 2021 to December 31, 2021. Effective January 1, 2022, Medicare has started to reimburse Guardant360 CDx services at the median rate of claims paid by commercial payers and this rate will apply until December 2023. In March 2022, Palmetto GBA, the Medicare administrative contractor for MolDX, has conveyed coverage for our Guardant360 TissueNext test under the existing local coverage determination. The policy covers our Guardant360 TissueNext test for Medicare fee-for-service patients with advanced solid tumor cancers. We are in the process of negotiating reimbursement for our Guardant Reveal and Guardant Response tests from commercial and governmental payers. Due to the inherent variability and unpredictability of the reimbursement landscape, including related to the amount that payers reimburse us for any of our tests, we estimate the amount of revenue to be recognized at the time a test is provided and record revenue adjustments if and when the cash subsequently received differs from the revenue recorded. Due to this variability and unpredictability, previously recorded revenue adjustments are not indicative of future revenue adjustments from actual cash collections, which may fluctuate significantly. Additionally, if coding changes were to occur, payments for certain uses of our tests could be reduced, put on hold, or eliminated. This variability and unpredictability could increase the risk of future revenue reversal and result in our failing to meet any previously publicly stated guidance we may provide.

•Biopharmaceutical customers. Our revenue also depends on our ability to attract, maintain and expand relationships with biopharmaceutical customers. As we continue to develop these relationships, we expect to support a growing number of clinical studies globally and continue to have opportunities to offer our platform to such customers for development services, including companion diagnostic development, novel target discovery

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and validation, as well as clinical study enrollment. For example, our tests are being developed as companion diagnostics under collaborations with biopharmaceutical companies, including AstraZeneca, Amgen, Daiichi Sankyo, Janssen Biotech, and Radius Health.

•Research and development. A significant aspect of our business is our investment in research and development, including the development of new products. In particular, we have invested heavily in clinical studies as we believe these studies are critical to gaining physician adoption and driving favorable coverage decisions by payers. With respect to Guardant Reveal, in October 2021, we initiated a 1,000-patient prospective, observational, multi-center study, which we refer to as the ORACLE study, designed to evaluate the performance of our Guardant Reveal liquid biopsy test to predict cancer recurrence after curative intent treatment, across 11 solid tumor types. With respect to Shield, in December 2021, we completed enrollment toward a prospective screening study, which we refer to as the ECLIPSE study, aiming to evaluate the performance of our Shield assay in detecting colorectal cancer in average-risk adults. In addition, in January 2022, we enrolled the first patient in a nearly 10,000-patient prospective, registrational study, which we refer to as the SHIELD study, to evaluate the performance of our next-generation Guardant SHIELD assay in detecting lung cancer in high-risk individuals ages 50-80 and the study is anticipated to run in approximately 100 centers in the United States and Europe. We have expended considerable resources, and expect to increase such expenditures over the next few years, to support our research and development programs with the goal of fueling further innovation.

•International expansion. A component of our long-term growth strategy is to expand our commercial footprint internationally, and we expect to increase our sales and marketing expense to execute on this strategy. We currently offer our tests in countries outside the United States primarily through distributor relationships, direct contracts with hospitals or partnerships with research organizations. In May 2018, we formed and capitalized a joint venture, Guardant Health AMEA, Inc., which we refer to as the Joint Venture, with SoftBank, relating to the sale, marketing and distribution of our tests generally outside the Americas and Europe. We expect to rely on the Joint Venture to accelerate commercialization of our products in Asia, the Middle East and Africa. In February 2021, an affiliate of the Joint Venture with SoftBank, submitted an application to Ministry of Health, Labour and Welfare, or the MHLW, for regulatory approval of Guardant360 CDx. In December 2021, MHLW granted regulatory approval of Guardant360 CDx as a companion diagnostic for identifying patients with metastatic NSCLC who may benefit from treatment with LUMAKRAS™ (sotorasib). In March 2022, MHLW granted regulatory approval of Guardant360® CDx in patients with advanced solid tumors. MHLW also approved Guardant360 CDx as a companion diagnostic to identify patients with microsatellite instability-high (MSI-High) solid tumors who may benefit from Keytruda® (pembrolizumab) and patients with MSI-High advanced colorectal cancer who may benefit from Opdivo® (nivolumab).

In November 2021, we exercised our call right contained in the joint venture agreement with SoftBank to purchase all of the shares held by SoftBank and its affiliates in consideration for the payment of the aggregate purchase price to be determined based on an independent third-party valuation. The aggregate purchase price will be no less than $78.0 million, which was determined based on 20% internal rate of return on the $41.0 million of capital invested by SoftBank in May 2018 as stipulated in the joint venture agreement. SoftBank and us have initiated a process to determine the independent valuation of the Joint Venture, which includes the appointment of independent appraisers by both SoftBank and us. We expect to complete this transaction before the end of the second quarter of 2022.

•Sales and marketing expense. Our financial results have historically, and will likely continue to, fluctuate significantly based upon the impact of our sales and marketing expense, increase in headcount, and in particular, our various marketing programs around existing and new product introductions.

•General and administrative expense. Our financial results have historically, and will likely continue to, fluctuate significantly based upon the impact of our general and administrative expense, and in particular, our stock-based compensation expense. Our equity awards, including market-based and performance-based restricted stock units, are intended to retain and incentivize employees to lead us to sustained, long-term superior financial and operational performance.

•COVID-19 Global Pandemic. The global coronavirus 2019, or COVID-19, pandemic has negatively affected, and we expect will continue to negatively affect, our revenue and our clinical studies. For example, our biopharmaceutical customers are facing challenges in recruiting patients and in conducting clinical studies to advance their pipelines, for which our tests could be utilized. In addition, disruptions caused by the pandemic have adversely affected the quantity and quality of certain sequencers, reagents, blood tubes and other similar materials that are critical to our commercial and research and development programs. We currently have a limited amount of stock of these components. Failure in the future to secure sufficient supply of critical

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components could materially and adversely affect our ability to manufacture or supply marketed products and product candidates or complete our ongoing research and development programs on the timelines previously established, which could materially and adversely affect our business and future prospects. The severity of the impact on our business will depend on a number of factors, including the duration and severity of the pandemic and the impact of any variants of the virus on us, our customers, and our suppliers.

While each of these areas presents significant opportunities for us, they also pose significant risks and challenges that we must address. See Part I, Item 1A, “Risk Factors” of our Annual Report on Form 10-K for the year ended December 31, 2021, and Part II, Item 1A, “Risk Factors” of this Quarterly Report on Form 10-Q, for more information.

Components of results of operations

Revenue

We derive our revenue from two sources: (i) precision oncology testing and (ii) development services and other.

Precision oncology testing. Precision oncology testing revenue is generated from sales of our tests to clinical and biopharmaceutical customers. In the United States, through March 31, 2022, we generally performed tests as an out-of-network service provider without contracts with health insurance companies. We submit claims for payment for tests performed for patients covered by U.S. private payers. We submit claims to Medicare for reimbursement for Guardant360 clinical testing performed for qualifying patients diagnosed with solid tumor cancers of non-central nervous system origin and for Guardant360 CDx clinical testing performed for qualifying patients diagnosed with solid tumor cancers who meet the criteria of Medicare’s National Coverage Determination for Next Generation Sequencing established since March 2018. Revenue from clinical tests for patients covered by Medicare represented approximately 44% and 39% of our precision oncology revenue from clinical customers during the three months ended March 31, 2022, and 2021, respectively.

Development services and other. Development services and other revenue primarily represents services, other than precision oncology testing, that we provide to biopharmaceutical companies and large medical institutions. We collaborate with biopharmaceutical companies in the development and clinical studies of new drugs. As part of these collaborations, we provide services related to regulatory filings to support companion diagnostic device submissions for our test panels. Under these arrangements, we generate revenue from progression of our collaboration efforts, as well as from provision of on-going support. In addition to companion diagnostic development and regulatory approval services, we also provide clinical study setup, monitoring and maintenance, testing development and support, GuardantConnect, GuardantINFORM, and kits fulfillment related services for our biopharmaceutical customers. In addition, we derive royalty revenues from licensing our technologies. Development services and other revenue can vary over time as different projects start and complete.

Costs and operating expenses

Cost of precision oncology testing. Cost of precision oncology testing generally consists of cost of materials, inventory write-downs, direct labor, including employee benefits, bonus, and stock-based compensation; equipment and infrastructure expenses associated with processing test samples, such as sample accessioning, library preparation, sequencing, quality control analyses and shipping charges to transport blood samples; freight; curation of test results for physicians; and license fees due to third parties. Infrastructure expenses include depreciation of laboratory equipment, rent costs, depreciation of leasehold improvements and information technology costs. Costs associated with performing our tests are recorded as the tests are performed regardless of whether revenue was recognized with respect to the tests. Royalties for licensed technology are calculated as a percentage of revenues generated using the associated technology and recorded as expense at the time the related revenue is recognized. One-time royalty payments related to signing of license agreements or other milestones, such as issuance of new patents, are amortized to expense over the expected useful life of the patents. While we do not believe the technologies underlying these licenses are necessary to permit us to provide our tests, we do believe these technologies are potentially valuable and of possible strategic importance to us or our competitors.

We expect the cost of precision oncology testing to generally increase in line with the increase in the number of tests we perform, but we expect the cost per test to decrease modestly over time due to the efficiencies we may gain as test volume increases, and from automation and other cost reductions.

Cost of development services and other. Cost of development services and other primarily includes costs incurred for the performance of development services requested by our customers comprising of direct labor and material costs including any inventory write-downs. For development of new products, costs incurred before technological feasibility has been achieved are reported as research and development expenses, while costs incurred thereafter are

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reported as cost of revenue. Cost of development services and other will vary depending on the nature, timing and scope of customer projects.

Research and development expense. Research and development expenses consist of costs incurred to develop technology and include salaries and benefits including stock-based compensation, reagents and supplies used in research and development laboratory work, infrastructure expenses, including allocated facility occupancy and information technology costs, contract services, other outside costs and costs to develop our technology capabilities. Research and development expenses also include costs related to activities performed under contracts with biopharmaceutical companies before technological feasibility has been achieved. Research and development costs are expensed as incurred. Payments made prior to the receipt of goods or services to be used in research and development are deferred and recognized as expense in the period in which the related goods are received or services are rendered. Costs to develop our technology capabilities are recorded as research and development unless they meet the criteria to be capitalized as internal-use software costs. We expect that our research and development expenses will continue to increase in absolute dollars as we continue to innovate and develop additional products, expand our genomic and medical data management resources and conduct our ongoing and new clinical studies.

Sales and marketing expense. Our sales and marketing expenses are expensed as incurred and include costs associated with our sales organization, including our direct sales force and sales management, client services, marketing and reimbursement, medical affairs, as well as business development personnel who are focused on our biopharmaceutical customers. These expenses consist primarily of salaries, commissions, bonuses, employee benefits, travel expenses and stock-based compensation, as well as marketing, sales incentives, and educational activities and allocated overhead expenses. We expect our sales and marketing expenses to increase in absolute dollars as we expand our sales force, increase our presence within and outside of the United States, and increase our marketing activities to drive further awareness and adoption of our tests.

General and administrative expense. Our general and administrative expenses include costs for our executive, accounting and finance, information technology, legal and human resources functions. These expenses consist principally of salaries, bonuses, employee benefits, travel expenses and stock-based compensation, as well as professional services fees such as consulting, audit, tax and legal fees, and general corporate costs and allocated overhead expenses. We expect that our general and administrative expenses will continue to increase as we incur additional costs to support the growth of our business. These expenses, though expected to increase in absolute dollars, are expected to decrease modestly as a percentage of revenue in the long term, though they may fluctuate as a percentage of revenue from period to period due to the timing and extent of these expenses being incurred.

Interest income

Interest income consists of interest earned on our cash, cash equivalents and marketable securities.

Interest expense

Interest expense consists primarily of charges relating to amortization of debt issuance costs.

Other income (expense), net

Other income (expense), net consists of foreign currency exchange gains and losses, non-recurring payments due and received in relation to the settlement of license and patent disputes, net of credit losses, and the relief fund grant from the Department of Health and Human Services, or HHS, under the U.S. Coronavirus Aid, Relief, and Economic Security Act, or the CARES Act. We expect our foreign currency gains and losses to continue to fluctuate in the future due to changes in foreign currency exchange rates.

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Results of operations

The following tables set forth the significant components of our results of operations for the periods presented.

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
Revenue:
Precision oncology testing	$	84,136	$	63,729
Development services and other	11,963		14,936
Total revenue	96,099		78,665
Costs and operating expenses:
Cost of precision oncology testing(1)	30,684		23,590
Cost of development services and other	1,297		5,157
Research and development expense(1)	81,757		55,508
Sales and marketing expense(1)	64,432		34,338
General and administrative expense(1)	41,267		67,935
Total costs and operating expenses	219,437		186,528
Loss from operations	(123,338)		(107,863)
Interest income	778		1,551
Interest expense	(644)		(646)
Other income (expense), net	(48)		(290)
Loss before provision for income taxes	(123,252)		(107,248)
Provision for (benefit from) income taxes	(24)		110
Net loss	$	(123,228)	$	(107,358)

(1)Amounts include stock-based compensation expense as follows:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
Cost of precision oncology testing	$	1,164	$	767
Research and development expense	5,343		4,300
Sales and marketing expense	5,525		2,880
General and administrative expense	12,767		47,122
Total stock-based compensation expense	$	24,799	$	55,069

Comparison of the Three Months Ended March 31, 2022 and 2021

Revenue

	Three Months Ended March 31,				Change
	2022		2021		$		%
	(unaudited)
	(in thousands)
Precision oncology testing	$	84,136	$	63,729	$	20,407	32	%
Development services and other	11,963		14,936		(2,973)		(20)	%
Total revenue	$	96,099	$	78,665	$	17,434	22	%

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Total revenue was $96.1 million for the three months ended March 31, 2022, compared to $78.7 million for the three months ended March 31, 2021, an increase of $17.4 million, or 22%.

Precision oncology testing revenue increased to $84.1 million for the three months ended March 31, 2022, from $63.7 million for the three months ended March 31, 2021, an increase of $20.4 million, or 32%.

Precision oncology revenue from tests for clinical customers was $66.0 million for the three months ended March 31, 2022, up 32% from $49.8 million for the three months ended March 31, 2021. This increase in clinical testing revenue was driven primarily by an increase in sample volume related to our Guardant360 CDx and Guardant360 LDT tests and revenue from products launched in 2021, including Guardant Reveal, Guardant360 Response and Guardant 360 TissueNext, and an overall increase in the average selling price per Guardant360 CDx test primarily due to advanced diagnostic laboratory test, or ADLT, status being received from Medicare effective April 1, 2021. Total tests for clinical customers increased to 27,100 for the three months ended March 31, 2022, from 18,390 for the three months ended March 31, 2021.

Precision oncology revenue from tests for biopharmaceutical customers was $18.1 million for the three months ended March 31, 2022, and $13.9 million for the three months ended March 31, 2021, respectively. This increase in revenue was primarily due to an increase in tests. Total tests for biopharmaceutical customers increased to 5,100 for the three months ended March 31, 2022, from 3,522 for the three months ended March 31, 2021, primarily due to an increase in the number of biopharmaceutical customers and their contracted projects.

Development services and other revenue decreased to $12.0 million for the three months ended March 31, 2022, from $14.9 million for the three months ended March 31, 2021, a decrease of $3.0 million, or 20%. This decrease in development services and other revenue was primarily due to the progression of collaboration projects with biopharmaceutical customers for companion diagnostic development and regulatory approval services, and discontinuation of our Guardant-19 tests in August 2021, partially offset by royalty revenues earned during the three months ended March 31, 2022.

Our revenue may be adversely impacted by the COVID-19 pandemic in future periods depending on the duration and severity of the pandemic and the impact of any variants of the virus.

Cost of Revenue

	Three Months Ended March 31,				Change
	2022		2021		$		%
	(unaudited)
	(in thousands)
Cost of precision oncology testing	$	30,684	$	23,590	$	7,094	30	%
Cost of development services and other	1,297		5,157		(3,860)		(75)	%
Total cost of revenue	$	31,981	$	28,747	$	3,234	11	%

Cost of revenue was $32.0 million for the three months ended March 31, 2022, compared to $28.7 million for the three months ended March 31, 2021, an increase of $3.2 million, or 11%.

Cost of precision oncology testing was $30.7 million for the three months ended March 31, 2022, compared to $23.6 million for the three months ended March 31, 2021, an increase of $7.1 million, or 30%. This increase in cost of precision oncology testing was primarily attributable to an increase in sample volumes, resulting in a $3.0 million increase in production labor and overhead costs, a $2.6 million increase in material costs, and a $1.6 million increase in other costs, including costs related to kits, freight and curation of test results for physicians.

Cost of development services and other was $1.3 million for the three months ended March 31, 2022, compared to $5.2 million for the three months ended March 31, 2021, a decrease of $3.9 million, or 75%. This decrease in cost of development services and other was primarily due to a decrease in labor costs and materials, related to the progression of companion diagnostic development and regulatory approval service contracts, and discontinuation of our Guardant-19 tests in August 2021.

41

Operating Expenses

Research and development expense

	Three Months Ended March 31,				Change
	2022		2021		$		%
	(unaudited)
	(in thousands)
Research and development	$	81,757	$	55,508	$	26,249	47	%

Research and development expenses were $81.8 million for the three months ended March 31, 2022, compared to $55.5 million for the three months ended March 31, 2021, an increase of $26.2 million, or 47%. This increase was primarily related to continued investment in our clinical studies and next-generation technologies, resulting in an increase of $9.7 million in personnel-related costs for employees in our research and development group, including a $1.0 million increase in stock-based compensation, an increase of $8.3 million in outside service fees related to clinical studies and product development, an increase of $4.1 million related to allocated facility and information technology infrastructure costs, and an increase of $2.1 million in post-acquisition related contingent consideration.

Sales and marketing expense

	Three Months Ended March 31,				Change
	2022		2021		$		%
	(unaudited)
	(in thousands)
Sales and marketing	$	64,432	$	34,338	$	30,094	88	%

Selling and marketing expenses were $64.4 million for the three months ended March 31, 2022, compared to $34.3 million for the three months ended March 31, 2021, an increase of $30.1 million, or 88%. This increase was primarily related to commercial infrastructure buildout and marketing activities to support existing products and new product launch, resulting in an increase of $22.6 million in personnel-related costs, including a $2.6 million increase in stock-based compensation, an increase of $2.8 million in professional service expenses related to marketing activities, an increase of $2.4 million in office administrative costs, and an increase of $2.2 million related to allocated facilities and information technology infrastructure costs.

General and administrative expense

	Three Months Ended March 31,				Change
	2022		2021		$		%
	(unaudited)
	(in thousands)
General and administrative	$	41,267	$	67,935	$	(26,668)	(39)	%

General and administrative expenses were $41.3 million for the three months ended March 31, 2022, compared to $67.9 million for the three months ended March 31, 2021, a decrease of $26.7 million, or 39%. This decrease was primarily due to a decrease of $34.4 million in stock-based compensation, as tranche 1 and tranche 2 of the market-based restricted stock units issued to our Co-Chief Executive Officers were fully expensed as of March 31, 2021 and December 31, 2021, respectively. This decrease was offset by an increase of $3.1 million in professional service expenses related to outside legal, accounting, consulting and IT services, an increase of $2.4 million in acquisition related contingent consideration, and an increase of $2.2 million related to allocated facilities and information technology infrastructure costs.

Interest income

	Three Months Ended March 31,				Change
	2022		2021		$		%
	(unaudited)
	(in thousands)
Interest income	$	778	$	1,551	$	(773)	(50)	%

42

Interest income was $0.8 million for the three months ended March 31, 2022, compared to $1.6 million for the three months ended March 31, 2021, a decrease of $0.8 million, or 50%. This decrease was primarily due to a decrease in cash and cash equivalents and marketable securities balances, partially offset by an increase in interest rate as the U.S. Federal Reserve increased the risk-free interest rate.

Interest expense

	Three Months Ended March 31,				Change
	2022		2021		$		%
	(unaudited)
	(in thousands)
Interest expense	$	(644)	$	(646)	$	2	*

*    Not meaningful

Interest expense was primarily attributable to amortization of debt issuance costs related to our convertible senior notes issued in November 2020, for the three months ended March 31, 2022, and 2021.

Other income (expense), net

	Three Months Ended March 31,				Change
	2022		2021		$		%
	(unaudited)
	(in thousands)
Other income (expense), net	$	(48)	$	(290)	$	242	*

*    Not meaningful

Other income (expense), net was immaterial for the three months ended March 31, 2022, and 2021.

Provision for income taxes

	Three Months Ended March 31,				Change
	2022		2021		$		%
	(unaudited)
	(in thousands)
Provision for (benefit from) income taxes	$	(24)	$	110	$	(134)	(122)	%

Provision for (benefit from) income taxes was immaterial for the three months ended March 31, 2022, and 2021.

Liquidity and capital resources

We have incurred losses and negative cash flows from operations since our inception, and as of March 31, 2022, we had an accumulated deficit of $1.1 billion. We expect to incur additional operating losses in the near future and our operating expenses will increase as we continue to invest in clinical studies and develop new products, expand our sales organization, and increase our marketing efforts to drive market adoption of our tests. As demand for our tests are expected to continue to increase from physicians and biopharmaceutical companies, we anticipate that our capital expenditure requirements could also increase if we require additional laboratory capacity.

We have funded our operations to date principally from the sale of stock, convertible debt and through revenue from precision oncology testing and development services and other. As of March 31, 2022, we had cash and cash equivalents of $573.6 million and marketable securities of $977.1 million. Cash in excess of immediate requirements is invested in accordance with our investment policy, primarily with a view to provide liquidity while ensuring capital preservation. Additionally, we have investments held in marketable securities consisting of United States treasury securities that can be immediately liquid.

Based on our current business plan, we believe our current cash, cash equivalents and marketable securities and anticipated cash flows from operations, will be sufficient to meet our anticipated cash requirements for more than 12 months from the date of this Quarterly Report on Form 10-Q. We may consider raising additional capital to expand our business, to pursue strategic investments, to take advantage of financing opportunities or for other reasons. As revenue from precision oncology testing and development services and other is expected to grow long-term, we

43

expect our accounts receivable and inventory balances to increase. Any increase in accounts receivable and inventory may not be completely offset by increases in accounts payable and accrued expenses, which could result in greater working capital requirements.

If our available cash, cash equivalents and marketable securities and anticipated cash flows from operations are insufficient to satisfy our liquidity requirements including because of lower demand for our products as a result of lower than currently expected rates of reimbursement from our customers or other risks described in our Form 10-K for the year ended December 31, 2021, we may seek to sell additional common or preferred equity or convertible debt securities, enter into a credit facility or another form of third-party funding or seek other debt financing. The sale of equity and convertible debt securities may result in dilution to our stockholders and, in the case of preferred equity securities or convertible debt, those securities could provide for rights, preferences or privileges senior to those of our common stock. The terms of debt securities issued or borrowings pursuant to a credit agreement could impose significant restrictions on our operations. If we raise funds through collaborations and licensing arrangements, we might be required to relinquish significant rights to our platform technologies or products or grant licenses on terms that are not favorable to us. Additional capital may not be available to us on reasonable terms, or at all.

Cash flows

The following table summarizes our cash flows for the periods presented:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
Net cash used in operating activities	$	(28,619)	$	(16,291)
Net cash provided by investing activities	$	110,808	$	123,870
Net cash used in financing activities	$	(12)	$	(69,953)

Operating activities

Cash used in operating activities during the three months ended March 31, 2022, was $28.6 million, which resulted from a net loss of $123.2 million, partially offset by non-cash charges of $44.5 million and net change in our operating assets and liabilities of $50.2 million. Non-cash charges primarily consisted of $24.8 million of stock-based compensation, $7.2 million of depreciation and amortization, $6.9 million of non-cash operating lease costs, $2.4 million of amortization of premium on marketable investments, and $2.4 million of revaluation adjustments to contingent consideration. The net change in our operating assets and liabilities was primarily the result of a $21.9 million decrease in prepaid expenses and other current assets, primarily driven by a $25.0 million one-time payment pursuant to a settlement and license agreement entered into in December 2021, a $13.7 million increase in accrued compensation due to increased personnel, a $13.3 million decrease in accounts receivable primarily driven by collection from our clinical and biopharmaceutical customers and receipt of royalty payments, a $8.0 million increase in accrued expense and other liabilities, and a $3.8 million decrease in other assets, partially offset by a $5.9 million increase in inventory due to higher testing volumes, and a $3.1 million payment of operating lease liabilities net of receipt of tenant improvement allowance.

Cash used in operating activities during the three months ended March 31, 2021 was $16.3 million, which resulted from a net loss of $107.4 million, partially offset by non-cash charges of $67.9 million and net change in our operating assets and liabilities of $23.2 million. Non-cash charges primarily consisted of $55.1 million of stock-based compensation, $5.0 million of depreciation and amortization, $3.9 million of non-cash operating lease costs, and $3.3 million of amortization of premium on investment. The net change in our operating assets and liabilities was primarily the result of a $12.0 million increase in accounts payable, a $8.9 million increase in accrued compensation due to increased personnel, a $5.3 million decrease in accounts receivables and a $4.4 million increase in accrued expenses and other liabilities, partially offset by a $6.2 million increase in inventory due to higher testing volumes, and a $2.8 million payment of operating lease liabilities net of receipt of tenant improvement allowance.

Investing activities

Cash provided by investing activities during the three months ended March 31, 2022, was $110.8 million, which resulted primarily from proceeds from the maturities of marketable securities of $310.0 million, partially offset by purchases of marketable securities of $163.7 million, purchases of property and equipment of $22.7 million, and purchases of non-marketable equity and other related investments of $12.8 million.

44

Cash provided by investing activities during the three months ended March 31, 2021, was $123.9 million, which resulted primarily from maturities of marketable securities of $204.1 million, partially offset by purchases of marketable securities of $70.7 million, and purchases of property and equipment of $9.6 million.

Financing activities

Cash used in financing activities during the three months ended March 31, 2022, was immaterial, which was primarily due to taxes paid related to net share settlement of restricted stock units of $1.0 million, partially offset by proceeds from exercise of stock options of $1.0 million.

Cash used in financing activities during the three months ended March 31, 2021, was $70.0 million, which was primarily due to taxes paid related to net share settlement of restricted stock units of $73.6 million, partially offset by proceeds from exercise of stock options of $4.5 million.

Critical accounting policies and estimates

We have prepared our consolidated financial statements in accordance with accounting principles generally accepted in the United States of America, or GAAP. Our preparation of these consolidated financial statements requires us to make estimates, assumptions and judgments that affect the reported amounts of assets, liabilities, expenses and related disclosures at the date of the consolidated financial statements, as well as revenue and expenses recorded during the reporting periods. We evaluate our estimates and judgments on an ongoing basis. We base our estimates on historical experience and on various other factors that we believe are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Actual results could therefore differ materially from these estimates under different assumptions or conditions.

Our significant accounting policies are described in more detail in Note 2 to our unaudited condensed consolidated financial statements included elsewhere in this Quarterly Report on Form 10-Q and in Item 7, “Management's Discussion and Analysis of Financial Condition and Results of Operations”, in our Annual Report on Form 10-K for the fiscal year ended December 31, 2021. During the three months ended March 31, 2022, there were no material changes to our critical accounting policies from those discussed previously.

Recent accounting pronouncements

Not applicable.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

We are exposed to market risk in the ordinary course of our business. Market risk represents the risk of loss that may impact our financial position due to adverse changes in financial market prices and rates.

Interest rate risk

We are exposed to market risk for changes in interest rates related primarily to our cash and cash equivalents, marketable securities and our indebtedness. As of March 31, 2022, we had cash and cash equivalents of $573.6 million held primarily in cash deposits and money market funds. Our marketable securities are held in U.S. government debt securities. As of March 31, 2022, we had short-term marketable securities of $388.7 million and long-term marketable securities of $588.5 million. Our primary exposure to market risk is interest income sensitivity, which is affected by changes in the general level of the interest rates in the United States. As of March 31, 2022, a hypothetical 100 basis point increase in interest rates would have resulted in an approximate $10.8 million decline of the fair value of our available-for-sale securities and a hypothetical 100 basis point decrease in interest rates would have resulted in an approximate $10.8 million increase of the fair value of our available-for-sale securities. This estimate is based on a sensitivity model that measures market value changes when changes in interest rates occur.

Foreign currency risk

The majority of our revenue is generated in the United States. Through March 31, 2022, we have generated an insignificant amount of revenues denominated in foreign currencies. As we expand our presence in the international market, our results of operations and cash flows are expected to increasingly be subject to fluctuations due to changes in foreign currency exchange rates and may be adversely affected in the future due to changes in foreign exchange rates. As of March 31, 2022, the effect of a hypothetical 10% change in foreign currency exchange rates would not be material to our financial condition or results of operations. To date, we have not entered into any

45

hedging arrangements with respect to foreign currency risk. As our international operations grow, we will continue to reassess our approach to manage our risk relating to fluctuations in currency rates.

Item 4. Controls and Procedures

Evaluation of disclosure controls and procedures

Our Co-Chief Executive Officers, or Co-CEOs, and our Chief Financial Officer, or CFO with the participation of other members of our management, have evaluated the effectiveness of our “disclosure controls and procedures” (as such term is defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended, or Exchange Act) as of March 31, 2022, and our Co-CEOs and our CFO have concluded that our disclosure controls and procedures are effective based on their evaluation of these controls and procedures as required by paragraph (b) of Exchange Act Rules 13a-15 or 15d-15.

Changes in internal control

There was no change in our internal control over financial reporting identified in connection with the evaluation required by Rule 13a-15(d) and 15d-15(d) of the Exchange Act that occurred during the period covered by this Quarterly Report on Form 10-Q that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting. We have not experienced any material impact to our internal controls over financial reporting despite the fact that a number of our employees are working remotely due to the COVID-19 pandemic. We are continually monitoring and assessing the COVID-19 situation on our internal controls to minimize the impact on their design and operating effectiveness.

Limitations on effectiveness of controls and procedures

Our management, including our Co-CEOs and our CFO, believes that our disclosure controls and procedures and internal control over financial reporting are designed to provide reasonable assurance of achieving their objectives and are effective at the reasonable assurance level. However, our management does not expect that our disclosure controls and procedures or our internal control over financial reporting will prevent all errors and all fraud. A control system, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of the control system are met. Further, the design of a control system must reflect the fact that there are resource constraints, and the benefits of controls must be considered relative to their costs. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, have been detected. These inherent limitations include the realities that judgments in decision making can be faulty, and that breakdowns can occur because of a simple error or mistake. Additionally, controls can be circumvented by the individual acts of some persons, by collusion of two or more people or by management override of the controls. The design of any system of controls also is based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions; over time, controls may become inadequate because of changes in conditions, or the degree of compliance with policies or procedures may deteriorate. Because of the inherent limitations in a cost-effective control system, misstatements due to error or fraud may occur and not be detected.

46

PART II—OTHER INFORMATION

Item 1. Legal Proceedings

The information under the caption “Commitments and Contingencies – Legal Proceedings” in Note 9 to the unaudited condensed consolidated financial statements included elsewhere in this Quarterly Report on Form 10-Q, concerning certain legal proceedings in which we are involved, is hereby incorporated by reference. The resolution of any such legal proceeding is subject to inherent uncertainty and could have a material adverse effect on our financial condition, cash flows or results of operations.

Item 1A. Risk Factors

Our business, financial condition and operating results are affected by a number of factors, whether currently known or unknown, including risks specific to us or the healthcare industry as well as risks that affect businesses in general. In addition to the information set forth in this Quarterly Report on Form 10-Q, you should consider carefully the factors discussed in Part I, Item 1A, “Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2021, filed with the SEC on February 24, 2022. The risks and uncertainties disclosed in such Annual Report and in this Quarterly Report could materially adversely affect our business, financial condition, cash flows or results of operations and thus our stock price. During the first quarter of fiscal 2022, there were no material changes to our previously disclosed risk factors. Besides risk factors disclosed in the Annual Report and this Quarterly Report, additional risks and uncertainties not currently known or we currently deem to be immaterial may also materially adversely affect our business, financial condition or results of operations.

These risk factors may be important to understanding other statements in this Quarterly Report and should be read in conjunction with the unaudited condensed consolidated financial statements and related notes in Part I, Item 1, “Financial Statements” and Part I, Item 2, “Management’s Discussion and Analysis of Financial Condition and Results of Operations” of this Quarterly Report. Because of such risk factors, as well as other factors affecting our financial condition and operating results, past financial performance should not be considered to be a reliable indicator of future performance, and investors should not use historical trends to anticipate results or trends in future periods.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.

None.

Item 3. Defaults Upon Senior Securities.

Not applicable.

Item 4. Mine Safety Disclosures.

Not applicable.

Item 5. Other Information.

Not applicable.

47

Item 6. Exhibits.

Exhibit Number	Description	Form	File No.	Exhibit	Filing Date	Filed/Furnished Herewith
3.1	Amended and Restated Certificate of Incorporation	8-K	001-38683	3.1	10/9/2018
3.2	Amended and Restated Bylaws	8-K	001-38683	3.2	10/9/2018
31.1	Certification of the Co-Chief Executive Officer pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002					*
31.2	Certification of the Co-Chief Executive Officer pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002					*
31.3	Certification of the Chief Financial Officer pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002					*
32.1	Certification of the Co-Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002					**
32.2	Certification of the Co-Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002					**
32.3	Certification of the Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002					**
101.INS	Inline XBRL Instance Document - the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document					*
101.SCH	Inline XBRL Taxonomy Extension Schema Document					*
101.CAL	Inline XBRL Taxonomy Extension Calculation Linkbase Document					*
101.DEF	Inline XBRL Taxonomy Extension Definition Linkbase Document					*
101.LAB	Inline XBRL Taxonomy Extension Label Linkbase Document					*
101.PRE	Inline XBRL Taxonomy Extension Presentation Linkbase Document					*
104	Cover Page Interactive Data File (formatted as inline XBRL with applicable taxonomy extension information contained in Exhibits 101)					*

___________________________

*    Filed herewith.

**    Furnished herewith.

48

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized

		GUARDANT HEALTH, INC.
Dated:	May 5, 2022	By:	/s/ Helmy Eltoukhy
		Name:	Helmy Eltoukhy
		Title:	Co-Chief Executive Officer and Chairman of the Board (Principal Executive Officer)
Dated:	May 5, 2022	By:	/s/ AmirAli Talasaz
		Name:	AmirAli Talasaz
		Title:	Co-Chief Executive Officer and Director (Principal Executive Officer)
Dated:	May 5, 2022	By:	/s/ Michael Bell
		Name:	Michael Bell
		Title:	Chief Financial Officer (Principal Accounting Officer and Principal Financial Officer)

49

EX-31.1

Exhibit 31.1

CERTIFICATION OF THE PRINCIPAL EXECUTIVE OFFICER

PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Helmy Eltoukhy, certify that:

1.I have reviewed this Quarterly Report on Form 10-Q of Guardant Health, Inc.;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a)    Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b)    Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c)    Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d)    Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a)    All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b)    Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date:	May 5, 2022	/s/ Helmy Eltoukhy
		Helmy Eltoukhy
		Co-Chief Executive Officer and Chairman of the Board
		(Principal Executive Officer)

EX-31.2

Exhibit 31.2

CERTIFICATION OF THE PRINCIPAL EXECUTIVE OFFICER

PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, AmirAli Talasaz, certify that:

1.I have reviewed this Quarterly Report on Form 10-Q of Guardant Health, Inc.;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a)    Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b)    Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c)    Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d)    Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a)    All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b)    Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date:	May 5, 2022	/s/ AmirAli Talasaz
		AmirAli Talasaz
		Co-Chief Executive Officer and Director
		(Principal Executive Officer)

EX-31.3

Exhibit 31.3

CERTIFICATION OF THE PRINCIPAL FINANCIAL OFFICER

PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Michael Bell, certify that:

1.I have reviewed this Quarterly Report on Form 10-Q of Guardant Health, Inc.;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a)    Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b)    Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c)    Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d)    Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a)    All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

(b)    Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date:	May 5, 2022	/s/ Michael Bell
		Michael Bell
		Chief Financial Officer
		(Principal Accounting Officer and Principal Financial Officer)

EX-32.1

Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Guardant Health, Inc. (the “Company”) on Form 10-Q for the period ended March 31, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that:

1.The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

2.The information contained in the Report fairly presents, in all material respects, the financial condition and result of operations of the Company.

Date:	May 5, 2022	/s/ Helmy Eltoukhy
		Helmy Eltoukhy
		Co-Chief Executive Officer and Chairman of the Board
		(Principal Executive Officer)

The foregoing certification is being furnished solely to accompany the Report pursuant to 18 U.S.C. § 1350, and is not being filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and is not to be incorporated by reference into any filing of the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

EX-32.2

Exhibit 32.2

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Guardant Health, Inc. (the “Company”) on Form 10-Q for the period ended March 31, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that:

1.The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

2.The information contained in the Report fairly presents, in all material respects, the financial condition and result of operations of the Company.

Date:	May 5, 2022	/s/ AmirAli Talasaz
		AmirAli Talasaz
		Co-Chief Executive Officer and Director
		(Principal Executive Officer)

The foregoing certification is being furnished solely to accompany the Report pursuant to 18 U.S.C. § 1350, and is not being filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and is not to be incorporated by reference into any filing of the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

EX-32.3

Exhibit 32.3

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Guardant Health, Inc. (the “Company”) on Form 10-Q for the period ended March 31, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that:

1.The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

2.The information contained in the Report fairly presents, in all material respects, the financial condition and result of operations of the Company.

Date:	May 5, 2022	/s/ Michael Bell
		Michael Bell
		Chief Financial Officer
		(Principal Accounting Officer and Principal Financial Officer)

The foregoing certification is being furnished solely to accompany the Report pursuant to 18 U.S.C. § 1350, and is not being filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and is not to be incorporated by reference into any filing of the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

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Cover - shares	3 Months Ended
	Mar. 31, 2022	Apr. 29, 2022
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Mar. 31, 2022
Document Transition Report	false
Entity File Number	001-38683
Entity Registrant Name	GUARDANT HEALTH, INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	45-4139254
Entity Address, Address Line One	3000 Hanover Street
Entity Address, City or Town	Palo Alto
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	94304
City Area Code	855
Local Phone Number	698-8887
Title of 12(b) Security	Common Stock, $0.00001 par value per share
Trading Symbol	GH
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		101,923,322
Amendment Flag	false
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q1
Entity Central Index Key	0001576280
Current Fiscal Year End Date	--12-31

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Condensed Consolidated Balance Sheets (unaudited) - USD ($) $ in Thousands		Mar. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents		$ 573,604	$ 492,202
Short-term marketable securities		388,662	440,546
Accounts receivable, net		84,331	97,652
Inventory		36,613	30,674
Prepaid expenses and other current assets, net		30,070	53,052
Total current assets		1,113,280	1,114,126
Long-term marketable securities		588,453	698,034
Property and equipment, net		151,322	124,461
Right-of-use assets, net		188,607	189,443
Intangible assets, net		13,727	14,207
Goodwill		3,290	3,290
Other assets, net		70,919	60,938
Total Assets	[1]	2,129,598	2,204,499
Current liabilities:
Accounts payable		32,230	17,580
Accrued compensation		56,158	42,496
Accrued expenses		51,851	45,285
Noncontrolling interest liability		78,000	78,000
Deferred revenue		10,570	11,326
Total current liabilities		228,809	194,687
Convertible senior notes, net		1,135,463	1,134,821
Long-term operating lease liabilities		225,377	226,053
Other long-term liabilities		6,909	3,933
Total Liabilities	[1]	1,596,558	1,559,494
Stockholders’ equity:
Preferred stock, par value of $0.00001 per share; 10,000,000 shares authorized, no shares issued and outstanding as of March 31, 2022 and December 31, 2021		0	0
Common stock, par value of $0.00001 per share; 350,000,000 shares authorized as of March 31, 2022, and December 31, 2021; 101,895,835 and 101,767,446 shares issued and outstanding as of March 31, 2022, and December 31, 2021, respectively		1	1
Additional paid-in capital		1,682,406	1,657,593
Accumulated other comprehensive loss		(18,314)	(4,764)
Accumulated deficit		(1,131,053)	(1,007,825)
Total Stockholders’ Equity		533,040	645,005
Total Liabilities and Stockholders’ Equity		$ 2,129,598	$ 2,204,499

[1] As of March 31, 2022 and December 31, 2021, this balance includes $16.9 million and $20.4 million of assets, respectively, that can be used only to settle obligations of the consolidated variable interest entity, or VIE and VIE’s subsidiaries, and $4.3 million and $4.3 million of liabilities of the consolidated VIE and VIE’s subsidiaries, respectively, for which their creditors do not have recourse to the general credit of the Company. See Note 3, Investment in Joint Venture.

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Condensed Consolidated Balance Sheets (unaudited) (Parenthetical) - USD ($) $ in Thousands		Mar. 31, 2022	Dec. 31, 2021
Preferred stock, par value (in usd per share)		$ 0.00001	$ 0.00001
Preferred stock, shares authorized (in shares)		10,000,000	10,000,000
Preferred stock issued (in shares)		0	0
Preferred stock outstanding (in shares)		0	0
Common stock, par value (in usd per share)		$ 0.00001	$ 0.00001
Common stock, shares authorized (in shares)		350,000,000	350,000,000
Common stock, shares outstanding (in shares)		101,895,835	101,767,446
Common stock, shares issued (in shares)		101,895,835	101,767,446
Assets	[1]	$ 2,129,598	$ 2,204,499
Liabilities	[1]	1,596,558	1,559,494
Variable Interest Entity
Assets		16,900	20,400
Liabilities		$ 4,300	$ 4,300

[1] As of March 31, 2022 and December 31, 2021, this balance includes $16.9 million and $20.4 million of assets, respectively, that can be used only to settle obligations of the consolidated variable interest entity, or VIE and VIE’s subsidiaries, and $4.3 million and $4.3 million of liabilities of the consolidated VIE and VIE’s subsidiaries, respectively, for which their creditors do not have recourse to the general credit of the Company. See Note 3, Investment in Joint Venture.

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Condensed Consolidated Statements of Operations (unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenue:
Precision oncology testing	$ 84,136	$ 63,729
Development services and other	11,963	14,936
Total revenue	96,099	78,665
Costs and operating expenses:
Cost of precision oncology testing	30,684	23,590
Cost of development services and other	1,297	5,157
Research and development expense	81,757	55,508
Sales and marketing expense	64,432	34,338
General and administrative expense	41,267	67,935
Total costs and operating expenses	219,437	186,528
Loss from operations	(123,338)	(107,863)
Interest income	778	1,551
Interest expense	(644)	(646)
Other income (expense), net	(48)	(290)
Loss before provision for income taxes	(123,252)	(107,248)
Provision for (benefit from) income taxes	(24)	110
Net loss	(123,228)	(107,358)
Adjustment of redeemable noncontrolling interest	0	(2,300)
Net loss attributable to Guardant Health, Inc. common stockholders	(123,228)	(109,658)
Net loss attributable to Guardant Health, Inc. common stockholders	$ (123,228)	$ (109,658)
Net loss per share attributable to Guardant Health, Inc. common stockholders, basic (in usd per share)	$ (1.21)	$ (1.09)
Net loss per share attributable to Guardant Health, Inc. common stockholders, diluted (in usd per share)	$ (1.21)	$ (1.09)
Weighted-average shares used in computing net loss per share attributable to Guardant Health, Inc. common stockholders, basic (in shares)	101,853	100,955
Weighted-average shares used in computing net loss per share attributable to Guardant Health, Inc. common stockholders, diluted (in shares)	101,853	100,955

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Condensed Consolidated Statements of Comprehensive Loss (unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Statement of Comprehensive Income [Abstract]
Net loss	$ (123,228)	$ (107,358)
Other comprehensive loss, net of tax impact:
Unrealized loss on available-for-sale securities	(12,758)	(706)
Foreign currency translation adjustments	(792)	(1,087)
Other comprehensive loss	(13,550)	(1,793)
Comprehensive loss	(136,778)	(109,151)
Comprehensive loss attributable to redeemable noncontrolling interest	0	(2,300)
Comprehensive loss attributable to Guardant Health, Inc.	$ (136,778)	$ (111,451)

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Condensed Consolidated Statements of Redeemable Noncontrolling Interest and Stockholders’ Equity (unaudited) - USD ($) $ in Thousands	Total	Cumulative effect adjustment for ASU 2020-06 adoption	Redeemable Noncontrolling Interest	Common Stock	Additional Paid-in Capital	Additional Paid-in Capital Cumulative effect adjustment for ASU 2020-06 adoption	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Accumulated Deficit Cumulative effect adjustment for ASU 2020-06 adoption
Beginning balance at Dec. 31, 2020			$ 57,100
Increase (Decrease) in Temporary Equity [Roll Forward]
Adjustment of redeemable noncontrolling interest	$ (2,300)		2,300					$ (2,300)
Ending balance at Mar. 31, 2021			59,400
Beginning balance (in shares) at Dec. 31, 2020				100,213,985
Beginning balance at Dec. 31, 2020	1,298,495	$ (325,966)		$ 1	$ 1,902,389	$ (330,403)	$ 2,697	(606,592)	$ 4,437
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)				282,879
Issuance of common stock upon exercise of stock options	4,462				4,462
Vesting of restricted stock units (in shares)				588,789
Vesting of common stock exercised early	13				13
Taxes paid related to net share settlement of restricted stock units	(73,576)				(73,576)
Stock-based compensation	55,069				55,069
Adjustment of redeemable noncontrolling interest	(2,300)		$ 2,300					(2,300)
Other comprehensive loss, net of tax impact	(1,793)						(1,793)
Net loss	(107,358)							(107,358)
Ending balance (in shares) at Mar. 31, 2021				101,085,653
Ending balance at Mar. 31, 2021	847,046			$ 1	1,557,954		904	(711,813)
Beginning balance (in shares) at Dec. 31, 2021				101,767,446
Beginning balance at Dec. 31, 2021	$ 645,005			$ 1	1,657,593		(4,764)	(1,007,825)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)	105,218			105,218
Issuance of common stock upon exercise of stock options	$ 963				963
Vesting of restricted stock units (in shares)				23,171
Vesting of common stock exercised early	8				8
Taxes paid related to net share settlement of restricted stock units	(957)				(957)
Stock-based compensation	24,799				24,799
Other comprehensive loss, net of tax impact	(13,550)						(13,550)
Net loss	(123,228)							(123,228)
Ending balance (in shares) at Mar. 31, 2022				101,895,835
Ending balance at Mar. 31, 2022	$ 533,040			$ 1	$ 1,682,406		$ (18,314)	$ (1,131,053)

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Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
OPERATING ACTIVITIES:
Net loss	$ (123,228)	$ (107,358)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	7,201	5,010
Non-cash operating lease costs	6,949	3,932
Re-valuation of contingent consideration	2,390	0
Non-cash stock-based compensation	24,799	55,069
Amortization of debt issuance costs	642	641
Amortization of premium (discount) on marketable securities	2,449	3,259
Other	21	0
Changes in operating assets and liabilities:
Accounts receivable, net	13,299	5,260
Inventory	(5,937)	(6,160)
Prepaid expenses and other current assets, net	21,882	521
Other assets, net	3,846	1,202
Accounts payable	(753)	11,986
Accrued compensation	13,662	8,900
Accrued expenses and other liabilities	8,022	4,399
Operating lease liabilities	(3,106)	(2,762)
Deferred revenue	(757)	(190)
Net cash used in operating activities	(28,619)	(16,291)
INVESTING ACTIVITIES:
Purchase of marketable securities	(163,742)	(70,654)
Maturity of marketable securities	310,000	204,110
Purchase of non-marketable equity and other related investments	(12,750)	0
Purchase of property and equipment	(22,700)	(9,586)
Net cash provided by investing activities	110,808	123,870
FINANCING ACTIVITIES:
Payments made on finance lease obligations	(18)	(55)
Proceeds from issuance of common stock upon exercise of stock options	963	4,462
Taxes paid related to net share settlement of restricted stock units	(957)	(73,576)
Payment of offering costs related to borrowings on convertible senior notes	0	(784)
Net cash used in financing activities	(12)	(69,953)
Net effect of foreign exchange rate changes on cash, cash equivalents and restricted cash	(792)	(1,087)
Net increase in cash, cash equivalents and restricted cash	81,385	36,539
Cash, cash equivalents and restricted cash—Beginning of period	492,288	832,977
Cash, cash equivalents and restricted cash—End of period	573,673	869,516
Supplemental Disclosures of Cash Flow Information:
Operating lease liabilities arising from obtaining right-of-use assets	3,940	170,847
Supplemental Disclosures of Noncash Investing and Financing Activities:
Purchase of property and equipment included in accounts payable and accrued expenses	19,751	5,881
Property and equipment acquired under finance leases	0	238
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	573,604	869,372
Restricted cash – included in other assets, net	69	144
Total cash, cash equivalents and restricted cash	$ 573,673	$ 869,516

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Description of Business	3 Months Ended
	Mar. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Description of Business	Description of BusinessGuardant Health, Inc., or the Company, is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. Today the Company's proprietary tests are helping to realize the full potential of precision oncology by providing patients and their doctors critical insights that can inform decisions at all stages of the disease, from detecting early signs of cancer, to monitoring cancer recurrence, to guiding treatment decisions. By looking at the unique dimensions of cancer found in blood, including genomic alterations, methylation, and fragmentomics, the Company is unlocking insights that can increasingly help patients across all stages of cancer, including at its earliest, when it’s most treatable. The Company provides its Guardant360 LDT, Guardant360 CDx and GuardantOMNI blood-based tests and Guardant360 TissueNext tissue-based tests for advanced stage cancer, Guardant Reveal blood-based tests to detect residual and recurring disease in Stage II-III colorectal cancer patients, and Guardant360 Response blood-based tests to predict patient response to immunotherapy or targeted therapy 8 weeks earlier than current standard-of-care imaging. In April 2022, the Company presented new data from its broad portfolio of blood tests at the American Association for Cancer Research Annual Meeting which demonstrated the ability of the Company’s investigational next-generation Guardant SHIELD multi-cancer assay to accurately detect early-stage cancers and identify the tumor tissue of origin with high accuracy. To help identify cancer at the earliest stages, in May 2022, the Company launched Shield LDT, a blood-based test to detect early signs of colorectal cancer in average-risk adults age 45 or older who show no symptoms and are not up to date with recommended screening guidelines. From a simple blood draw, the test uses a novel multimodal approach to detect colorectal cancer signals in the bloodstream, including DNA that is shed by tumors. Using data collected from the Company's tests, the Company has also developed the GuardantINFORM platform to further accelerate precision oncology drug development by biopharmaceutical companies by offering them an in-silico research platform to further unlock insights into tumor evolution and treatment resistance across various biomarker-driven cancers.The Company was incorporated in Delaware in December 2011 and is headquartered in Palo Alto, California. In May 2018, the Company formed and capitalized Guardant Health AMEA, Inc., or the Joint Venture, in the United States with an affiliate of SoftBank Vision Fund (AIV M1) L.P., or SoftBank. Under the terms of the joint venture agreement, the Company holds a 50% ownership interest in the Joint Venture. In November 2021, the Company exercised its call right contained in the Joint Venture agreement with SoftBank to purchase all of the shares held by SoftBank and its affiliates (see Note 3, Investment in Joint Venture).

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Summary of Significant Accounting Policies

3 Months Ended

Mar. 31, 2022

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

Summary of Significant Accounting Policies

Basis of Presentation

The Company’s condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America, or GAAP. The accompanying condensed consolidated financial statements include the accounts of Guardant Health, Inc., its consolidated Joint Venture and majority owned subsidiaries. Other stockholders’ interests in the Joint Venture are shown in the condensed consolidated financial statements as noncontrolling interest liability. All significant intercompany balances and transactions have been eliminated in consolidation.

The Company believes that its existing cash and cash equivalents and marketable securities as of March 31, 2022, will be sufficient to allow the Company to fund its current operating plan through at least a period of one year after the date the accompanying condensed consolidated financial statements are issued. As the Company continues to incur losses, its transition to profitability is dependent upon a level of revenues adequate to support the Company’s cost structure. If the Company’s transition to profitability is not consistent with its current operating plan, the Company may have to seek additional capital.

Use of Estimates

The preparation of condensed consolidated financial statements in conformity with GAAP requires management to make certain estimates, judgments and assumptions that affect the reported amounts of assets and liabilities and the related disclosures at the date of the condensed consolidated financial statements, as well as the reported amounts of revenues and expenses during the periods presented. The Company bases its estimates on historical experience and other market-specific or other relevant assumptions that it believes to be reasonable under the circumstances. Estimates are used in several areas including, but not limited to, estimation of variable consideration, estimation of credit losses, standalone selling price allocation included in contracts with multiple performance obligations,

goodwill and identifiable intangible assets, stock-based compensation, incremental borrowing rate for operating leases, contingencies, certain inputs into the provision for (benefit from) income taxes, including related reserves, valuation of non-marketable securities, valuation of redeemable noncontrolling interest and noncontrolling interest liability, among others. These estimates generally involve complex issues and require judgments, involve the analysis of historical results and prediction of future trends, can require extended periods of time to resolve and are subject to change from period to period. Actual results may differ materially from management’s estimates.

The severity of the impact on the Company's business for the remainder of calendar year 2022 and beyond will depend on a number of factors, including, but not limited to, the duration and severity of the pandemic, and the impact of any variants of the virus, the extent and severity of the impact on the Company's customers and suppliers, the continued disruption to demand for the Company's products and services, and the impact of the global business and economic environment on liquidity and the availability of capital, all of which are uncertain and cannot be predicted.

Unaudited Interim Condensed Financial Statements

The accompanying condensed consolidated balance sheet as of March 31, 2022, the condensed consolidated statements of operations for the three months ended March 31, 2022, and 2021, the condensed consolidated statements of comprehensive loss for the three months ended March 31, 2022, and 2021, the condensed consolidated statements of redeemable noncontrolling interest and stockholders’ equity for the three months ended March 31, 2022, and 2021, and cash flows for the three months ended March 31, 2022, and 2021, and the related interim condensed consolidated disclosures are unaudited. The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with GAAP for interim financial information and in accordance with the instructions to Form 10-Q and Rule 10-01 of Regulation S-X of the Securities Act of 1933, as amended, or the Securities Act. Accordingly, they do not include all of the information and notes required by GAAP for complete financial statements. These unaudited condensed consolidated financial statements include all adjustments, consisting only of normal recurring accruals that the Company believes are necessary to fairly state the financial position and the results of the Company’s operations and cash flows for interim periods in accordance with GAAP. Interim-period results are not necessarily indicative of results of operations or cash flows for a full year or any subsequent interim period.

The accompanying condensed consolidated financial statements should be read in conjunction with the Company’s audited financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021.

Foreign Currency

The functional currency of the subsidiaries of the consolidated Joint Venture is the local currency. The assets and liabilities of the subsidiaries are translated into U.S. dollars at exchange rates in effect at each balance sheet date, with the resulting translation adjustments recorded to a separate component of accumulated other comprehensive loss within stockholders’ equity. Income and expense accounts are translated at average exchange rates during the period. Foreign currency transaction gains and losses resulting from transactions denominated in a currency other than the functional currency are recognized in the condensed consolidated statements of operations. For the three months ended March 31, 2022, and 2021, foreign currency transaction gains and losses were immaterial.

Restricted Cash

Restricted cash consists of payroll withholding related to the Company's enrollment in certain voluntary disability insurance plan. Restricted cash balance was $0.1 million and $0.1 million as of March 31, 2022, and December 31, 2021, respectively, which was included in other assets in the accompanying condensed consolidated balance sheets.

Non-Marketable Securities

The Company acquires certain equity investments in private companies to promote business and strategic objectives. The Company's investments in non-marketable equity securities do not give the Company the ability to control or exercise significant influence over the investee. The Company's non-marketable equity and other related investments totaled $52.2 million and $39.4 million as of March 31, 2022, and December 31, 2021, respectively, and are included in other assets, net on the accompanying condensed consolidated balance sheets. Non-marketable securities are subject to periodic impairment reviews and adjustments for observable price changes from orderly transactions. The Company's evaluation of impairment of such non-marketable securities is based on adverse changes in market conditions and the regulatory or economic environment, qualitative and quantitative analysis of the operating performance of the investee; changes in operating structure or management of the investee; additional funding requirements; and the investee’s ability to remain in business. Pursuant to one of the investments in non-marketable

securities purchased by the Company, the Company acquired rights to purchase the investee at a pre-determined price subject to additional adjustments based on the performance of the investee, on or before December 31, 2022. As of March 31, 2022, no impairment or downward adjustments to the carrying value of non-marketable securities have been recorded. The Company’s assessment of these factors in determining whether an impairment exists could change in the future due to new developments or changes in applied assumptions.

Concentration of Risk

The Company is subject to credit risk from its portfolio of cash equivalents held at one commercial bank and investments in marketable securities. The Company limits its exposure to credit losses by investing in money market funds through a U.S. bank with high credit ratings. The Company’s cash may consist of deposits held with banks that may at times exceed federally insured limits, however, its exposure to credit risk in the event of default by the financial institution is limited to the extent of amounts recorded on the condensed consolidated balance sheets. The Company performs evaluations of the relative credit standing of these financial institutions to limit the amount of credit exposure.

The Company also invests in investment-grade debt instruments and has policy limits for the amount it can invest in any one type of security, except for securities issued or guaranteed by the U.S. government. The goals of the Company’s investment policy, in order of priority, are as follows: safety and preservation of principal and diversification of risk; liquidity of investments sufficient to meet cash flow requirements; and a competitive after-tax rate of return. Under its investment policy, the Company limits amounts invested in such securities by credit rating, maturity, investment type and issuer, as a result, the Company is not exposed to any significant concentrations of credit risk from these financial instruments.

The Company is subject to credit risk from its accounts receivable. The majority of the Company’s accounts receivable arises from the provision of precision oncology services and development services and other in the United States and are primarily with biopharmaceutical companies with high credit ratings. The Company has not experienced any material losses related to receivables from individual customers, or groups of customers. The Company does not require collateral. Accounts receivable are recorded at net amount.

A significant customer is a biopharmaceutical customer or a clinical testing payer that represents 10% or more of the Company’s total revenue or accounts receivable balance. Revenue attributable to each significant customer, including its affiliated entities, as a percentage of the Company’s total revenue, for the respective period, and accounts receivable balance attributable to each significant customers, including its affiliated entities, as a percentage of the Company’s total accounts receivable balance, at the respective condensed consolidated balance sheet date, are as follows:

	Revenue				Accounts Receivable, Net
	Three Months Ended March 31,				March 31, 2022		December 31, 2021
	2022		2021
	(unaudited)				(unaudited)
Customer A	30	%	25	%	10	%	13	%
Customer B	*		*		11	%	10	%
Customer C	*		*		*		13	%
Customer D	*		*		16	%	*

*    less than 10%

The Company is also subject to credit risk from its other receivables and other assets. The Company's other receivables and other assets include payments due from a third-party in relation to the settlement of a patent dispute reached in August 2020 for $8.0 million payable over a period of 6 years. In December 2020, the Company received the first installment payment of $1.0 million, and in December 2021, the Company received the second installment payment of $1.1 million. The Company has evaluated and recorded a credit loss for the remaining $5.9 million considering the third-party's credit worthiness and lack of financial history.

The following table presents the receivable and the related credit loss amounts:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Prepaid expenses and other current assets:
Gross Amount	$	1,100	$	—
Allowance for Credit Losses	(1,100)		—
Net Amount	$	—	$	—
Other assets:
Gross Amount	$	4,800	$	5,900
Allowance for Credit Losses	(4,800)		(5,900)
Net Amount	$	—	$	—

The following table summarizes the allowance for credit losses activities:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
Prepaid expenses and other current assets:
Allowance for credit losses—Beginning of period	$	—	$	—
Reclassification	1,100		1,100
Allowance for credit losses—End of period	$	1,100	$	1,100
Other assets:
Allowance for credit losses—Beginning of period	$	5,900	$	7,000
Reclassification	(1,100)		(1,100)
Allowance for credit losses—End of period	$	4,800	$	5,900

Accounts Receivable, Net

Accounts receivable represent valid claims against commercial and governmental payers, biopharmaceutical companies, research institutes and international distributors, including unbilled receivables, and royalty payments due from third parties for licensing the Company’s technologies. Unbilled receivables include balances due from biopharmaceutical customers related to development services and other revenues that are recognized upon the achievement of performance-based milestones but prior to the achievement of contractual billing rights. As of March 31, 2022, and December 31, 2021, the Company had unbilled receivables of $3.1 million and $5.7 million, respectively.

The Company evaluates the collectability of its accounts receivable based on historical collection trends, the financial condition of payment partners, and external market factors and provides for an allowance for potential credit losses based on management’s best estimate of the amount of probable credit losses. As of March 31, 2022, and December 31, 2021, the Company had immaterial allowance for credit losses related to its accounts receivable.

Asset Acquisition

If an acquisition of an asset or group of assets does not meet the definition of a business, the transaction is accounted for as an asset acquisition rather than a business combination. An asset acquisition does not result in the recognition of goodwill and transaction costs are capitalized as part of the cost of the asset or group of assets acquired. Transaction costs allocated to in-process research and development technology with no future alternate use is expensed as incurred. The total consideration is allocated to the various intangible assets acquired on a relative fair value basis. Cash paid in connection of purchase of in-process research and development technology in an asset acquisition is presented within the investing section of the condensed consolidated statement of cash flows.

Goodwill and Intangible Assets, net

Intangible assets related to in-process research and development costs, or IPR&D, acquired in a business combination are considered to be indefinite-lived until the completion or abandonment of the associated research

and development efforts. If and when development is complete, the associated assets would be deemed finite-lived and would then be amortized based on their respective estimated useful lives at that point in time. Prior to completion of the research and development efforts, the assets are considered indefinite-lived. During this period, the assets will not be amortized but will be tested for impairment on an annual basis and between annual tests if the Company becomes aware of any events occurring or changes in circumstances that would indicate a reduction in the fair value of the IPR&D projects below their respective carrying amounts.

Goodwill represents the excess of the purchase price over the fair value of net identifiable assets and liabilities. Goodwill and IPR&D are not amortized but are tested for impairment at least annually during the fourth fiscal quarter, or if circumstances indicate their value may no longer be recoverable. The Company continues to operate in one segment, which is considered to be the sole reporting unit and, therefore, goodwill was tested for impairment at the enterprise level. As of March 31, 2022, there has been no impairment of goodwill or IPR&D.

Intangible assets are carried at cost, net of accumulated amortization. The Company does not have intangible assets with indefinite useful lives other than goodwill and the acquired IPR&D. Amortization is recorded on a straight-line basis over the intangible asset's useful life, which is approximately 6—12 years.

Post-acquisition Contingent Consideration

Post-acquisition contingent consideration is recognized over the service period, subject to meeting the respective service requirements and performance metrics. For the three months ended March 31, 2022, and 2021, the Company recorded post-acquisition contingent consideration expense of $2.1 million and zero, respectively, in research and development expenses on the Company's condensed consolidated statement of operations.

Leases

The Company determines if an arrangement contains a lease at inception. Operating lease right-of-use, or ROU, assets and operating leases liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. ROU assets also include any initial direct costs incurred and any lease payments made at or before the lease commencement date, less lease incentives received or receivable. The Company uses its incremental borrowing rate based on the information available at the commencement date in determining the lease liabilities, as the Company's leases generally do not provide an implicit rate. Lease terms may include options to extend or terminate when the Company is reasonably certain the option will be exercised. Lease expense is recognized on a straight-line basis over the lease term. The Company also has lease arrangements with lease and non-lease components. The Company elected the practical expedient not to separate non-lease components from lease components for the Company’s facility leases. The Company also elected to apply the short-term lease measurement and recognition exemption in which ROU assets and lease liabilities are not recognized for leases with terms of 12 months or less.

Convertible Senior Notes

Upon early adoption of ASU 2020-06, Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity on January 1, 2021, the Company reclassified the carrying amount of the equity component of the cash conversion feature including the allocated debt issuance costs from additional paid-in capital to convertible senior notes, net. Convertible senior notes are accounted for as a liability and measured at their amortized cost. Transaction costs related to the issuance of the notes are netted with the liability and are amortized to interest expense over the term of the notes, using an effective interest rate method.

Revenue Recognition

The Company derives revenue from the provision of precision oncology testing services provided to its ordering physicians and biopharmaceutical customers, as well as from biopharmaceutical research and development services provided to its biopharmaceutical customers. Precision oncology testing services include genomic profiling and the delivery of other genomic information derived from the Company’s platform. Development services and other include companion diagnostic development, clinical study setup, monitoring and maintenance, information solutions and laboratory services, and other miscellaneous revenue streams. The Company currently receives payments from third-party commercial and governmental payers, certain hospitals and oncology centers and individual patients, as well as biopharmaceutical companies, research institutes and international distributors.

Revenues are recognized when control of services is transferred to customers, in an amount that reflects the consideration the Company expects to be entitled to in exchange for those services. ASC 606 provides for a five-step model that includes identifying the contract with a customer, identifying the performance obligations in the contract,

determining the transaction price, allocating the transaction price to the performance obligations, and recognizing revenue when, or as, an entity satisfies a performance obligation.

Precision oncology testing

The Company recognizes revenue from the sale of its precision oncology tests for clinical customers, including certain hospitals, cancer centers, other institutions and patients, at the time results of the test are reported to physicians. Most precision oncology tests requested by clinical customers are sold without a written agreement; however, the Company determines an implied contract exists with its clinical customers. The Company identifies each sale of its test to a clinical customer as a single performance obligation. With the exception of certain limited contracted arrangements with insurance carriers and other institutions where the transaction price is fixed, a stated contract price does not exist and the transaction price for each implied contract with clinical customers represents variable consideration. The Company estimates the variable consideration under the portfolio approach and considers the historical reimbursement data from third-party commercial and governmental payers and patients, as well as known or anticipated reimbursement trends not reflected in the historical data. The Company monitors the estimated amount to be collected in the portfolio at each reporting period based on actual cash collections in order to assess whether a revision to the estimate is required. Both the estimate and any subsequent revision contain uncertainty and require the use of significant judgment in the estimation of the variable consideration and application of the constraint for such variable consideration. The Company analyzes its actual cash collections over the expected reimbursement period and compares it with the estimated variable consideration for each portfolio and any difference is recognized as an adjustment to estimated revenue after the expected reimbursement period, subject to assessment of the risk of future revenue reversal. For the three months ended March 31, 2022, and 2021, the Company recorded $2.0 million and $5.1 million as revenue, respectively, resulting from cash collections exceeding the estimated variable consideration related to samples processed in previous periods, including revenue received from successful appeals of reimbursement denials, net of recoupments.

Revenue from sales of precision oncology tests to biopharmaceutical customers are based on a negotiated price per test or on the basis of an agreement to provide certain testing volume over a defined period. The Company identifies its promise to transfer a series of distinct tests to biopharmaceutical customers as a single performance obligation. Precision oncology tests to biopharmaceutical customers are generally billed at a fixed price for each test performed. For agreements involving testing volume to be satisfied over a defined period, revenue is recognized over time based on the number of tests performed as the performance obligation is satisfied over time. Results of the Company’s precision oncology services are delivered electronically, and as such there are no shipping or handling fees incurred by the Company or billed to customers.

Development services and other

The Company performs development services for its biopharmaceutical customers utilizing its precision oncology information platform. Development services typically represent a single performance obligation as the Company performs a significant integration service, such as analytical validation and regulatory submissions. The individual promises are not separately identifiable from other promises in the contracts and, therefore, are not distinct. However, under certain contracts, a biopharmaceutical customer may engage the Company for multiple distinct development services which are both capable of being distinct and separately identifiable from other promises in the contracts and, therefore, distinct performance obligations.

The Company collaborates with pharmaceutical companies in the development of new drugs. As part of these collaborations, the Company provides services related to regulatory filings to support companion diagnostic device submissions for the Company’s testing panels. Under these collaborations, the Company generates revenue from achievement of milestones, as well as provision of on-going support. For development services performed, the Company is compensated through a combination of an upfront fee and performance-based, non-refundable regulatory and other developmental milestone payments. The transaction price of the Company's development services contracts typically represents variable consideration. Application of the constraint for variable consideration to milestone payments is an area that requires significant judgment. The Company evaluates factors such as the scientific, clinical, regulatory, commercial, and other risks that must be managed to achieve the respective milestone and the level of effort and investment required to achieve the respective milestone. In making this assessment, the Company considers its historical experience with similar milestones, the degree of complexity and uncertainty associated with each milestone, and whether achievement of the milestone is dependent on parties other than the Company. The constraint for variable consideration is applied such that it is probable a significant reversal of revenue will not occur when the uncertainty associated with the contingency is resolved. Application of the constraint for variable consideration is assessed and updated at each reporting period as a revision to the estimated transaction price.

The Company recognizes development services revenue over the period in which biopharmaceutical research and development services are provided. Specifically, the Company recognizes revenue using an input method to measure progress, utilizing costs incurred to-date relative to total expected costs as its measure of progress. The Company assesses the changes to the total expected cost estimates as well as any incremental fees negotiated resulting from changes to the scope of the original contract in determining the revenue recognition at each reporting period. For development of new products or services under these arrangements, costs incurred before technological feasibility is reached are included as research and development expenses in the Company’s condensed consolidated statements of operations, while costs incurred thereafter are recorded as cost of development services and other.

The Company also has other miscellaneous revenue streams that are recognized in addition to development services noted above such as clinical study setup, monitoring and maintenance, testing development and support, GuardantConnect, GuardantINFORM, and kits fulfillment related revenues. Revenues related to clinical study setup, monitoring and maintenance, testing development and support, GuardantConnect, and GuardantINFORM are generally recognized over time based on an input method to measure progress in the period when the associated services have been performed. Kits fulfillment related revenues are recognized when such products are delivered. In addition, the Company derives sales-based royalty revenues from licensing its technologies. Royalty revenues are recognized in the period when royalty-bearing sales occur.

Contracts with multiple performance obligations

Contracts with biopharmaceutical customers may include multiple distinct performance obligations, such as provision of precision oncology testing, biopharmaceutical research and development services, and clinical study enrollment assistance, among others. The Company evaluates the terms and conditions included within its contracts with biopharmaceutical customers to ensure appropriate revenue recognition, including whether services are considered distinct performance obligations that should be accounted for separately versus together. The Company first identifies material promises, in contrast to immaterial promises or administrative tasks, under the contract, and then evaluates whether these promises are both capable of being distinct and distinct within the context of the contract. In assessing whether a promised service is capable of being distinct, the Company considers whether the customer could benefit from the service either on its own or together with other resources that are readily available to the customer, including factors such as the research, development, and commercialization capabilities of a third party as well as the availability of the associated expertise in the general marketplace. In assessing whether a promised service is distinct within the context of the contract, the Company considers whether it provides a significant integration of the services, whether the services significantly modify or customize one another, or whether the services are highly interdependent or interrelated.

For contracts with multiple performance obligations, the transaction price is allocated to the separate performance obligations on a relative standalone selling price basis. The Company determines standalone selling price by considering the historical selling price of these performance obligations in similar transactions as well as other factors, including, but not limited to, the price that customers in the market would be willing to pay, competitive pricing of other vendors, industry publications and current pricing practices, and expected costs of satisfying each performance obligation plus appropriate margin.

Deferred revenue

Deferred revenue, which is a contract liability, consists primarily of payments received in advance of revenue recognition from contracts with customers. For example, development services and other contracts with biopharmaceutical customers often contain upfront payments which results in the recording of deferred revenue to the extent cash is received prior to the Company's performance of the related services. Contract liabilities are relieved as the Company performs its obligations under the contract and revenue is consequently recognized. As of March 31, 2022, and December 31, 2021, the deferred revenue balance was $10.6 million and $11.3 million, respectively. Revenue recognized in the three months ended March 31, 2022 that was included in the deferred revenue balance as of December 31, 2021 was $3.5 million, and revenue recognized in the three months ended March 31, 2021 that was included in the deferred revenue balance as of December 31, 2020 was $5.0 million, respectively.

Transaction price allocated to the remaining performance obligations

Transaction price allocated to remaining performance obligations represents contracted revenue that has not yet been recognized, which includes deferred revenue and non-cancelable amounts that will be invoiced and recognized as revenues in future periods. The Company expects to recognize substantially all of the remaining transaction price in the next 12 months.

Costs of Precision Oncology Testing

Cost of precision oncology testing generally consists of cost of materials, direct labor including bonus, benefit and stock-based compensation, equipment and infrastructure expenses associated with processing test samples (including sample accessioning, library preparation, sequencing, quality control analyses and shipping charges to transport blood samples), freight, curation of test results for physicians and license fees due to third parties. Infrastructure expenses include depreciation of laboratory equipment, rent costs, amortization of leasehold improvements and information technology costs. Costs associated with performing the Company’s tests are recorded as the tests are performed regardless of whether revenue was recognized with respect to that test. Royalties for licensed technology calculated as a percentage of revenues generated using the associated technology are recorded as expense at the time the related revenues are recognized. One-time royalty payments related to signing of license agreements or other milestones, such as issuance of new patents, are amortized to expense over the expected useful life of the applicable patent rights.

Cost of Development Services and Other

Cost of development service and other primarily includes costs incurred for the performance of development services requested by the Company’s biopharmaceutical customers and other revenues included as noted above. For development of new products, costs incurred before technological feasibility has been achieved are reported as research and development expenses, while costs incurred thereafter are reported as cost of development services and other.

Research and Development Expenses

Research and development expenses are comprised of costs incurred to develop technology and include compensation and benefits, reagents and supplies used in research and development laboratory work, infrastructure expenses, including allocated facility occupancy and information technology costs, contract services and other outside costs. Research and development costs are expensed as incurred. Payments made prior to the receipt of goods or services to be used in research and development are deferred and recognized as expense in the period in which the related goods are received or services are rendered. Costs to develop the Company’s technology capabilities are recorded as research and development unless they meet the criteria to be capitalized as internal-use software costs.

Stock-Based Compensation

Stock-based compensation related to stock options granted to the Company’s and the Joint Venture's employees, directors and nonemployees is measured at the grant date based on the fair value of the award. The fair value is recognized as expense over the requisite service period, which is generally the vesting period of the respective awards. Compensation expense for stock options with performance metrics is calculated based upon expected achievement of the metrics specified in the grant.

The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock options granted under the 2012 Stock Plan, the 2018 Incentive Award Plan, and the Joint Venture's 2020 Equity Incentive Plan, and stock purchase rights granted under the 2018 Employee Stock Purchase Plan. The Black-Scholes option-pricing model requires assumptions to be made related to the expected term of an award, expected volatility, risk-free rate and expected dividend yield. The board of directors of the Joint Venture has determined the fair value of common stock of the Joint Venture. Forfeitures are accounted for as they occur.

For market-based restricted stock units, the Company derives the requisite service period using the Monte Carlo simulation model and the related compensation expense is recognized over the derived service period using an accelerated attribution model commencing on the grant date. Stock-based compensation expense will be recorded regardless of whether the market conditions are achieved or not. If the related market condition is achieved earlier than its estimated derived service period, the stock-based compensation expense will be accelerated, and a cumulative catch-up expense will be recorded during the period in which the market condition is met.

The Company measures the grant date fair value of its service-based and performance-based restricted stock units issued to employees based on the closing market price of the common stock on the date of grant. For restricted stock units with only service-based vesting conditions, compensation expense is recognized in the Company’s condensed consolidated statement of operations on a straight-line basis over the requisite service period. Compensation expense for restricted stock units with performance metrics is calculated based upon expected achievement of the metrics specified in the grant, and is recognized in the Company’s condensed consolidated statement of operations using an accelerated attribution model over the requisite service period for each separately vesting portion of the award.

Net Loss Per Share Attributable to Common Stockholders

The Company calculates basic net loss per share attributable to common stockholders by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding for the period. The diluted net loss per share attributable to common stockholders is computed by giving effect to all potential dilutive common stock equivalents outstanding for the period determined using the treasury stock method or the as-if converted method, as appropriate. For purposes of this calculation, stock options, restricted stock units, shares issuable pursuant to the employee stock purchase plan, shares subject to repurchase from early exercised options and contingently issuable shares under the convertible senior notes are considered common stock equivalents but have been excluded from the calculation of diluted net loss per share attributable to common stockholders as their effect is anti-dilutive.

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Investment in Joint Venture

3 Months Ended

Mar. 31, 2022

Equity Method Investments and Joint Ventures [Abstract]

Investment in Joint Venture

Investment in Joint Venture

Variable Interest Entity, or VIE

In May 2018, the Company and an affiliate of SoftBank formed and capitalized the Joint Venture for the sale, marketing and distribution of the Company’s tests in all areas worldwide, outside of North America, Central America, South America, the United Kingdom, all other member states of the European Union as of May 9, 2017, Iceland, Norway, Switzerland and Turkey. The Company expects to rely on the Joint Venture to accelerate commercialization of its products in Asia, the Middle East and Africa.

Under the terms of the joint venture agreement, the Company paid $9.0 million for 40,000 shares of common stock, or 50% ownership interest, of the Joint Venture, and the affiliate of SoftBank contributed $41.0 million for 40,000 shares of common stock, or the other 50% ownership interest, of the Joint Venture. In June 2020, an amended and restated certificate of incorporation of the Joint Venture, as approved by the board of directors of the Joint Venture, was filed with the Secretary of State of the State of Delaware. The amended and restated certificate of incorporation, among other things, increased the number of authorized shares of common stock to 89,000,000 shares consisting of 80,000,000 shares of Class A common stock and 9,000,000 shares of Class B (non-voting) common stock; and authorized 80,000,000 shares of Series A preferred stock. Pursuant to the amended and restated certificate of incorporation, each share of common stock held by the Company and the affiliate of SoftBank was reclassified and exchanged for 1,000 shares of Series A preferred stock. As a result, each of the Company and the affiliate of SoftBank held 40,000,000 shares of Series A preferred stock. The holders of Series A preferred stock are entitled to receive dividends at the rate of $0.05 per share if and when declared by the board of directors of the Joint Venture. In June 2020, the board of directors of the Joint Venture authorized the adoption of the Joint Venture’s 2020 Equity Incentive Plan pursuant to which 4,595,555 shares of Class B common stock have been reserved for issuance. As of March 31, 2022, and December 31, 2021, 1,184,428 and 602,408 shares of Class B common stock have been issued and outstanding, respectively, and no shares of Class A common stock have been issued and outstanding. As of March 31, 2022, and December 31, 2021, 80,000,000 shares of Series A preferred stock have been issued and outstanding.

Under the terms of the joint venture agreement, neither party is obligated to make any further capital contribution, in cash or otherwise, to the Joint Venture. The Joint Venture is deemed to be a VIE and the Company has been identified as the VIE’s primary beneficiary. As the primary beneficiary, the Company has consolidated the financial position, results of operations and cash flows of the Joint Venture in its financial statements and all intercompany balances have been eliminated in consolidation.

As of March 31, 2022, and December 31, 2021, the Joint Venture had total assets of approximately $16.9 million and $20.4 million, respectively, which were primarily comprised of cash, property and equipment and right-of-use assets. Although the Company consolidates the Joint Venture, the legal structure of the Joint Venture limits the recourse that its creditors will have over the Company’s general credit or assets. Similarly, the assets held in the Joint Venture can be used only to settle obligations of the Joint Venture. As of March 31, 2022, and December 31, 2021, the Company has not provided financial or other support to the Joint Venture that was not previously contracted or required.

Put-call arrangements

The joint venture agreement includes a put-call arrangement with respect to the shares of the Joint Venture held by SoftBank and its affiliates. Under certain specified circumstances and on terms specified in the joint venture agreement, including timely written notice, SoftBank has the right to cause the Company to purchase all shares of the Joint Venture held by SoftBank and its affiliates, or the put right, and the Company has a right to purchase all such shares, or the call right.

In November 2021, the Company exercised its call right contained in the joint venture agreement with SoftBank to purchase all of the shares held by SoftBank and its affiliates in consideration for the payment of the aggregate purchase price to be determined based on an independent third-party valuation. Upon the Company's exercise of the call right in November 2021, SoftBank no longer has the option to exercise its put right. The Company and SoftBank have initiated a process to determine the independent valuation of the Joint Venture, which includes the appointment of independent appraisers by both SoftBank and the Company. As of March 31, 2022, the estimated aggregate purchase price was $78.0 million, which represented the minimum contractual purchase price and was recorded in current liabilities in the Company’s condensed consolidated balance sheet. The minimum aggregate purchase price has been calculated based on a 20% annual internal rate of return on the $41.0 million of capital invested by SoftBank in May 2018 as stipulated in the joint venture agreement up through the date the Company exercised the call right. The Company expects to complete this transaction before the end of the second quarter of 2022.

The Company may pay the purchase price for the shares of the Joint Venture in cash, in shares of its capital stock (which may be a non-voting security with senior preferences to all other classes of its equity or, if its common stock is publicly traded on a national exchange, its common stock), or in a combination thereof, based on SoftBank’s election.

Prior to November 2021, the noncontrolling interest held by SoftBank contained embedded put-call redemption features that were not solely within the Company’s control and had been classified outside of permanent equity in the consolidated balance sheets. The put-call feature embedded in the redeemable noncontrolling interest did not require bifurcation as it did not meet the definition of a derivative and was considered to be clearly and closely related to the redeemable noncontrolling interest. The Company elected to recognize the changes in redemption value immediately as they occur as if the put-call redemption feature were exercisable at the end of the reporting period. The carrying value of the redeemable noncontrolling interest was first adjusted for the earnings or losses attributable to the redeemable noncontrolling interest based on the percentage of the economic or ownership interest retained in the consolidated VIE by the noncontrolling parties, and then adjusted to equal to its redemption amount, or the fair value of the noncontrolling interest held by SoftBank, as if the redemption occurred at the end of the reporting date. The adjustment of redeemable noncontrolling interest was recorded as an adjustment to net loss attributable to Guardant Health, Inc. common stockholders in the Company's condensed consolidated statement of operations.

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Condensed Consolidated Balance Sheet Components

3 Months Ended

Mar. 31, 2022

Balance Sheet Related Disclosures [Abstract]

Condensed Consolidated Balance Sheet Components

Condensed Consolidated Balance Sheet Components

Property and Equipment, Net

Property and equipment, net consist of the following:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Machinery and equipment	$	69,583	$	63,022
Leasehold improvements	75,295		38,702
Computer hardware	21,787		16,685
Construction in progress(1)	37,104		55,873
Furniture and fixtures	7,596		3,683
Computer software	1,439		1,320
Property and equipment, gross	$	212,804	$	179,285
Less: accumulated depreciation	(61,482)		(54,824)
Property and equipment, net	$	151,322	$	124,461

(1)    As of March 31, 2022, and December 31, 2021, $16.2 million and $45.8 million of construction in progress was related to leasehold improvements, furniture and equipment for the office in Palo Alto, California, respectively. In February 2022, part of the Palo Alto office was put in service and related construction in progress was transferred to fixed assets.

Depreciation expense related to property and equipment was $6.7 million and $4.5 million for the three months ended March 31, 2022, and 2021, respectively.

Accrued Expenses

Accrued expenses consist of the following:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Operating lease liabilities	$	16,556	$	12,856
Accrued tax liabilities	4,401		4,223
Accrued professional services	8,410		6,994
Accrued clinical studies	5,151		3,332
Accrued legal expenses	6,429		4,166
Purchases of property and equipment included in accrued expenses	1,349		5,893
Others	9,555		7,821
Total accrued expenses	$	51,851	$	45,285

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Fair Value Measurements, Cash Equivalents and Marketable Securities

3 Months Ended

Mar. 31, 2022

Fair Value Disclosures [Abstract]

Fair Value Measurements, Cash Equivalents and Marketable Securities

Fair Value Measurements, Cash Equivalents and Marketable Securities

Financial instruments consist of cash equivalents, marketable securities, accounts receivable, net, prepaid expenses and other current assets, net, accounts payable and accrued expenses. Cash equivalents and marketable securities are stated at fair value. Prepaid expenses and other current assets, net, accounts payable and accrued expenses are stated at their carrying value, which approximates fair value due to the short time to the expected receipt or payment date.

Fair value is defined as the exchange price that would be received from sale of an asset or paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. The identification of market participant assumptions provides a basis for determining what inputs are to be used for pricing each asset or liability. A financial instrument’s classification within the fair value hierarchy is based upon the lowest level of input that is significant to the fair value measurement.

A fair value hierarchy has been established which gives precedence to fair value measurements calculated using observable inputs over those using unobservable inputs. This hierarchy prioritized the inputs into three broad levels as follows:

Level 1 - Quoted prices in active markets for identical assets or liabilities.

Level 2 - Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3 - Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

The Company’s financial assets and liabilities subject to fair value measurements on a recurring basis and the level of inputs used in such measurements were as follows:

	March 31, 2022
	Fair Value		Level 1		Level 2		Level 3
	(unaudited)
	(in thousands)
Financial Assets:
Money market funds	$	447,032	$	447,032	$	—	$	—
Total cash equivalents	$	447,032	$	447,032	$	—	$	—
U.S. government debt securities	$	388,662	$	—	$	388,662	$	—
Total short-term marketable securities	$	388,662	$	—	$	388,662	$	—
U.S. government debt securities	$	588,453	$	—	$	588,453	$	—
Total long-term marketable securities	$	588,453	$	—	$	588,453	$	—
Total	$	1,424,147	$	447,032	$	977,115	$	—
Financial Liabilities:
Contingent consideration	$	6,015	$	—	$	—	$	6,015
Total	$	6,015	$	—	$	—	$	6,015

	December 31, 2021
	Fair Value		Level 1		Level 2		Level 3
	(in thousands)
Financial Assets:
Money market funds	$	357,785	$	357,785	$	—	$	—
Total cash equivalents	$	357,785	$	357,785	$	—	$	—
U.S. government debt securities	$	440,546	$	—	$	440,546	$	—
Total short-term marketable securities	$	440,546	$	—	$	440,546	$	—
U.S. government debt securities	$	698,034	$	—	$	698,034	$	—
Total long-term marketable securities	$	698,034	$	—	$	698,034	$	—
Total	$	1,496,365	$	357,785	$	1,138,580	$	—
Financial Liabilities:
Contingent consideration	$	3,625	$	—	$	—	$	3,625
Total	$	3,625	$	—	$	—	$	3,625

The Company measures the fair value of money market funds based on quoted prices in active markets for identical securities. U.S. government debt securities are valued taking into consideration valuations obtained from third-party pricing services. The pricing services utilize industry standard valuation models, including both income and market-based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include reported trades of and broker/dealer quotes on the same or similar securities, issuer credit spreads; benchmark securities; prepayment/default projections based on historical data and other observable inputs.

There were no transfers between Level 1, Level 2 and Level 3 during the periods presented.

Acquisition-related contingent consideration is measured at fair value on a quarterly basis and change in estimated contingent consideration to be paid are included in operating expenses in the condensed consolidated statements of operations. The fair value of acquisition-related contingent consideration is estimated using a multiple-outcome discounted cash flow valuation technique. Contingent consideration is classified within Level 3 of the fair value hierarchy, as it is based on a probability that includes significant unobservable inputs. The significant unobservable inputs include a probability-weighted estimate of achievement of certain commercialization milestones, and discount rate to present value the expected payments. A significant change in any of these input factors in isolation could have a material impact to fair value measurement. As of March 31, 2022, the Company recorded contingent consideration liability of $6.0 million, of which $4.5 million is considered long-term and was recorded within other long-term liabilities on the accompanying condensed consolidated balance sheets. As of December 31, 2021, the Company recorded contingent consideration liability of $3.6 million within other long-term liabilities on the accompanying condensed consolidated balance sheets.

As of March 31, 2022, and December 31, 2021, the fair value of the noncontrolling interest liability is considered to be a Level 3 measurement and was determined based on an annual internal rate of return of 20% on the initial amount of $41.0 million invested by SoftBank in May 2018, to the date of Company's exercising the call right in November 2021.

The following table summarizes the activities for the Level 3 financial instruments:

	Noncontrolling Interest Liability		Redeemable Noncontrolling Interest		Contingent Consideration
	Three Months Ended March 31,		Three Months Ended March 31,		Three Months Ended March 31,
	2022		2021		2022		2021
	(unaudited)
	(in thousands)
Fair value — beginning of period	$	78,000	$	57,100	$	3,625	$	1,245
Increase in fair value	—		4,287		2,390		—
Net loss for the period	—		(1,987)		—		—
Fair value — end of period	$	78,000	$	59,400	$	6,015	$	1,245

The Company considers the fair value of the Convertible Notes as of March 31, 2022, and December 31, 2021, to be a Level 2 measurement. The fair value of the Convertible Notes is primarily affected by the trading price of the Company's common stock and market interest rates. As such, the carrying value of the Convertible Notes does not reflect the market rate. See Note 7, Debt, for additional information related to the fair value of the Convertible Notes.

Cash Equivalents and Marketable Securities

The following tables summarizes the Company’s cash equivalents and marketable securities’ amortized costs, gross unrealized gains, gross unrealized losses and estimated fair values by significant investment category:

	March 31, 2022
	Amortized Cost		Gross Unrealized Gain		Gross Unrealized Loss		Estimated Fair Value
	(unaudited)
	(in thousands)
Money market fund	$	447,032	$	—	$	—	$	447,032
U.S. government debt securities	993,465		—		(16,350)		977,115
Total	$	1,440,497	$	—	$	(16,350)	$	1,424,147

	December 31, 2021
	Amortized Cost		Gross Unrealized Gain		Gross Unrealized Loss		Estimated Fair Value
	(in thousands)
Money market fund	$	357,785	$	—	$	—	$	357,785
U.S. government debt securities	1,142,172		2		(3,594)		1,138,580
Total	$	1,499,957	$	2	$	(3,594)	$	1,496,365

There have been no material realized gains or losses on marketable securities for the periods presented. None of the Company’s investments in marketable securities has been in an unrealized loss position for more than one year. The Company determined that it did have the ability and intent to hold all marketable securities that have been in a continuous loss position until maturity or recovery and the loss position was temporary due to market volatility, thus there has been no recognition of credit losses in the three months ended March 31, 2022, and 2021, respectively. The maturities of the Company’s long-term marketable securities range from 1.0 to 1.8 years as of March 31, 2022.

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Intangible Assets, Net and Goodwill

3 Months Ended

Mar. 31, 2022

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible Assets, Net and Goodwill

Intangible Assets, Net and Goodwill

The following table presents details of purchased intangible assets as of March 31, 2022, and December 31, 2021:

	March 31, 2022
	Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount		Remaining Weighted-Average Useful Life
	(unaudited)
	(in thousands)						(in years)
Intangible assets subject to amortization:
Acquired license	$	11,886	$	(2,746)	$	9,140	8.5
Non-compete agreements and other covenant rights	5,100		(2,113)		2,987		3.7
Total intangible assets subject to amortization	16,986		(4,859)		12,127
Intangible assets not subject to amortization:
IPR&D	1,600		—		1,600
Goodwill	3,290		—		3,290
Total purchased intangible assets	$	21,876	$	(4,859)	$	17,017

	December 31, 2021
	Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount		Remaining Weighted-Average Useful Life
	(in thousands)						(in years)
Intangible assets subject to amortization:
Acquired license	$	11,886	$	(2,473)	$	9,413	8.8
Non-compete agreements and other covenant rights	5,100		(1,906)		3,194		3.9
Total intangible assets subject to amortization	16,986		(4,379)		12,607
Intangible assets not subject to amortization:
IPR&D	1,600		—		1,600
Goodwill	3,290		—		3,290
Total purchased intangible assets	$	21,876	$	(4,379)	$	17,497

Amortization of finite-lived intangible assets was $0.5 million and $0.5 million for the three months ended March 31, 2022, and 2021, respectively.

The following table summarizes estimated future amortization expense of finite-lived intangible assets, net:

Year Ending December 31,
	(unaudited)
	(in thousands)
Remainder of 2022	$	1,467
2023	1,947
2024	1,953
2025	1,670
2026	1,212
2027 and thereafter	3,878
Total	$	12,127

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Debt

3 Months Ended

Mar. 31, 2022

Debt Disclosure [Abstract]

Debt

Debt

Convertible Senior Notes

In November 2020, the Company issued $1.15 billion principal amount of its 0% Convertible Senior Notes due 2027, or the 2027 Notes. The 2027 Notes do not bear interest, and the principal amount of the Notes will not accrete. However, special interest and additional interest may accrue on the 2027 Notes at a rate per annum not exceeding 0.50% (subject to certain exceptions) upon the occurrence of certain events such as the failure to file certain reports to the Securities and Exchange Commission, or to remove certain restrictive legends from the Notes. The Notes will mature on November 15, 2027, unless repurchased, redeemed or converted earlier.

Before August 15, 2027, holders of the 2027 Notes will have the right to convert their 2027 Notes only under the following circumstances:

•during any calendar quarter (and only during such calendar quarter) commencing after the calendar quarter ending on March 31, 2021, if the last reported sale price of the Company's common stock exceeds 130% of the conversion price for each of at least 20 trading days (whether or not consecutive) during the 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter, or the sale price condition;

•during the five consecutive business days immediately after any ten consecutive trading day period, or the measurement period, if the trading price per $1,000 principal amount of the Notes for each trading day of the measurement period is less than 98% of the product of the last reported sale price of the Company's common stock on such trading day and the conversion rate on such trading day; or

•upon the occurrence of specified corporate events

From and after August 15, 2027, holders of the 2027 Notes may convert their 2027 Notes at any time at their election until the close of business on the second scheduled trading day immediately before the maturity date.

The Company will settle conversions by paying or delivering, as applicable, cash, shares of its common stock or a combination of cash and shares of its common stock, at the Company’s election.

The initial conversion rate is 7.1523 shares of common stock per $1,000 principal amount of 2027 Notes, which represents an initial conversion price of approximately $139.82 per share of common stock. The conversion rate and conversion price will be subject to customary adjustments upon the occurrence of certain events. In addition, if certain corporate events that constitute a “Make-Whole Fundamental Change” occur, then the conversion rate will, in certain circumstances, be increased for a specified period of time.

The Company may not redeem the 2027 Notes at its option at any time before November 20, 2024. The Notes will be redeemable, in whole or in part, at the Company’s option at any time, and from time to time, on or after November 20, 2024 and on or before the 25th scheduled trading day immediately before the maturity date, at a cash redemption price equal to the principal amount of the Notes to be redeemed, plus accrued and unpaid special interest and additional interest, if any, to, but excluding, the redemption date, but only if the last reported sale price per share of the Company’s common stock exceeds 130% of the conversion price on (i) each of at least 20 trading days,

whether or not consecutive, during the 30 consecutive trading days ending on, and including, the trading day immediately before the date the Company sends the related redemption notice; and (ii) the trading day immediately before the date the Company sends such notice. In addition, calling any Note for redemption will constitute a Make-Whole Fundamental Change with respect to that Note, in which case the conversion rate applicable to the conversion of that Note will be increased in certain circumstances if it is converted after it is called for redemption.

If certain corporate events that constitute a “Fundamental Change” occur, then, subject to a limited exception for certain cash mergers, holders of Notes may require the Company to repurchase their 2027 Notes at a cash repurchase price equal to the principal amount of the 2027 Notes to be repurchased, plus accrued and unpaid special interest and additional interest, if any, to, but excluding, the fundamental change repurchase date. The definition of Fundamental Change includes certain business combination transactions involving the Company and certain de-listing events with respect to the Company’s common stock.

Since the 2027 Notes were not convertible as of March 31, 2022, the net carrying amount of the 2027 Notes was classified as a long-term liability.

The following table sets forth the net carrying amounts of the 2027 Notes as of March 31, 2022, and December 31, 2021:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Liability component:
Principal	$	1,150,000	$	1,150,000
Less: debt issuance costs, net of amortization	(14,537)		(15,179)
Net carrying amount	$	1,135,463	$	1,134,821

The total estimated fair value of the 2027 Notes was $0.9 billion and $1.2 billion as of March 31, 2022, and December 31, 2021, respectively. The fair value was determined based on the closing trading price per $100 of the 2027 Notes as of the last day of trading for the period.

The interest expense recognized in relation to amortization of debt issuance costs was $0.6 million and $0.6 million for the three months ended March 31, 2022, and 2021, respectively, which represented an effective interest rate of 0.2% and 0.2% for the three months ended March 31, 2022, and 2021, respectively.

Note Hedges

To minimize the impact of potential economic dilution upon conversion of the 2027 Notes, the Company entered into convertible note hedge transactions, or the 2027 Note Hedges, with respect to its common stock concurrent with the issuance of the Notes. The 2027 Note Hedges cover, subject to customary adjustments, the number of shares of common stock initially underlying the Notes. The strike price of the 2027 Note Hedges will initially be approximately $182.60 per share, which represents a premium of 75% over the last reported sale price of the Company’s common stock of $104.34 per share on November 16, 2020, and is subject to certain adjustments under the terms of the 2027 Note Hedges.

The 2027 Note Hedges will expire upon maturity of the 2027 Notes. The 2027 Note Hedges are separate transactions and are not part of the terms of the 2027 Notes. Holders of the 2027 Notes will not have any rights with respect to the 2027 Note Hedges. The shares receivable related to the 2027 Note Hedges are excluded from the calculation of diluted earnings per share as they are anti-dilutive.

As these transactions meet certain accounting criteria, the 2027 Note Hedges are recorded in stockholders’ equity and are not accounted for as derivatives. The Company paid an aggregate amount of $90.0 million for the 2027 Note Hedges, which has been recorded as a reduction to additional paid-in capital and will not be remeasured.

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Leases

3 Months Ended

Mar. 31, 2022

Leases [Abstract]

Leases

LeasesThe Company has entered into various operating lease agreements for office space, data center, lab and warehouse use, with remaining terms ranging from 1 year to 12 years some of which include one or more options to renew. As leases approach maturity, the Company considers various factors such as market conditions and the terms of any renewal options that may exist to determine whether it will renew the lease, as such, the Company does not include renewal options in its lease terms for calculating its lease liability, as the renewal options allow it to maintain

operational flexibility and the Company is not reasonably certain it will exercise these renewal options at the time of the lease commencement. In July 2020, the Company entered into two lease agreements for additional office space in Palo Alto, California, or the Palo Alto Lease, and in San Diego, California, or the San Diego Lease. The San Diego Lease has a term of 8 years with rent payments commencing in May 2022. The Palo Alto Lease has a term of 12 years with an option to renew the lease term for an additional ten years which has not been considered in the determination of ROU or the lease liability as the Company does not consider it reasonably certain of exercising the renewal option. After the initial payment of $0.9 million in February 2022, the remaining rent payments for the Palo Alto Lease will commence in June 2022. Both leases consist of fixed and variable payments and are being accounting for as operating leases. The Company took possession of these facilities in March 2021. The Company estimated the incremental borrowing rate to determine the present value of lease payments for the San Diego and Palo Alto leases using trading data of the Company's convertible debt adjusted for credit rating and market yield curves.

Operating lease expense was $6.9 million and $3.9 million for the three months ended March 31, 2022, and 2021, respectively, which includes both lease and non-lease components (primarily common area maintenance charges and property taxes).

	March 31, 2022		December 31, 2021
	(unaudited)
Weighted-average remaining lease term (in years)	9.7		10.0
Weighted-average discount rate	4.02	%	4.01	%

The following table summarizes the Company's future principal contractual obligations for operating lease commitments as of March 31, 2022:

Year Ending December 31,
	(unaudited)
	(in thousands)
Remainder of 2022	$	17,030
2023	30,363
2024	32,891
2025	32,238
2026	27,753
2027 and thereafter	149,637
Total operating lease payments	$	289,912
Less: imputed interest	(47,979)
Total operating lease liabilities	$	241,933

Finance leases are not material to the Company's condensed consolidated financial statements.

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Commitments and Contingencies

3 Months Ended

Mar. 31, 2022

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

Commitments and Contingencies

Legal Proceedings

In addition to commitments and obligations incurred in the ordinary course of business, from time to time the Company may be subject to a variety of claims and legal proceedings, including claims from customers and vendors, pending and potential legal actions for damages, governmental investigations and other matters. For example, the Company has received, and may in the future continue to receive letters, claims or complaints from others alleging false advertising, patent infringement, violation of employment practices and trademark infringement. The Company has also instituted, and may in the future institute, additional legal proceedings to enforce its rights and seek remedies, such as monetary damages, injunctive relief and declaratory relief. The Company cannot predict the results of any such disputes, and despite the potential outcomes, the existence thereof may have an adverse material impact on the Company because of diversion of management time and attention as well as the financial costs related to resolving such disputes.

The Company and its affiliates are parties to the legal claims and proceedings described below. The Company is vigorously defending itself against those claims and in those proceedings. Significant developments in those matters

are described below. If the Company is unsuccessful in defending, or if it determines to settle, any of these matters, it may be required to pay substantial sums, be subject to injunction and/or be forced to change how it operates its business, which could have a material adverse impact on its financial position or results of operations.

Unless otherwise stated, the Company is unable to reasonably estimate the loss or a range of possible loss for the matters described below. Often, it is not reasonably possible for the Company to determine that a loss is probable for a claim, or to reasonably estimate the amount of loss or a range of loss, because of the limited information available and the potential effects of future events and decisions by third parties, such as courts and regulators, that will determine the ultimate resolution of the claim. Many of the matters described are at preliminary stages, raise novel theories of liability or seek an indeterminate amount of damages. It is not uncommon for claims to be resolved over a number of years. The Company reviews loss contingencies at least quarterly to determine whether the loss probability has changed and whether it can make a reasonable estimate of the possible loss or range of loss. When the Company determines that a loss from a claim is probable and reasonably estimable, it records a liability in the amount of its estimate for the ultimate loss. The Company also provides disclosure when it is reasonably possible that a loss may be incurred or when it is reasonably possible that the amount of a loss will exceed its recorded liability.

Intellectual Property Disputes

In August 2021, TwinStrand Biosciences, Inc., or TwinStrand Biosciences, and the University of Washington filed a patent infringement suit in the United States District Court for the District of Delaware alleging that the Company infringes U.S. Patent Nos. 10,287,631; 10,689,699; 10,752,951; and 10,760,127. The Company answered the complaint in October 2021, denying TwinStrand Biosciences’ allegations and asserted counterclaims of invalidity, unenforceability due to inequitable conduct and infringement of four of the Company’s patents. Discovery in the case is ongoing and trial is scheduled to commence in November 2023.

In March 2022, Illumina Inc., or Illumina, filed suit in the United States District Court for the District of Delaware against the Company and its Co-Chief Executive Officers, Dr. Helmy Eltoukhy, or Dr. Eltoukhy, and Dr. AmirAli Talasaz, or Dr. Talasaz, or collectively the Defendants, alleging that Illumina is the owner of certain of the Company’s patents and patent applications, and that the Defendants allegedly misappropriated Illumina trade secrets. Illumina also alleges that Drs. Eltoukhy and Talasaz breached various Illumina employment contracts, company policies, and implied covenants of good faith and fair dealing as part of their former employment with Illumina prior to starting the Company. Illumina is requesting unspecified compensatory and punitive damages, attorneys’ fees, and specific performance in the form of a declaration of ownership and assignment of intellectual property filed for or obtained by the Defendants that derives from the alleged misuse of Illumina confidential information. The Defendants deny the allegations of misconduct. The court has not yet entered a scheduling order.

False Advertising Dispute

In May 2021, the Company also filed a lawsuit against Natera, Inc., or Natera, in the United States District Court for the Northern District of California, wherein the Company alleged that Natera is misleading healthcare providers about the performance of the Company’s new oncology test, Guardant Reveal, by suggesting the test is inaccurate and/or insensitive, and inferior to Natera’s Signatera assay. The Company is seeking an injunction to prevent Natera from continuing to make false and misleading statements and to require Natera to take corrective actions. Natera has asserted counterclaims of false and misleading statements, false advertising, unlawful trade practices and unfair competition. The Company moved to dismiss Natera’s counterclaims, and in January 2022, the court granted in part and denied in part the Company's motion to dismiss. Discovery is ongoing and trial is scheduled to commence in February 2023.

Civil Investigative Demand

In January 2022, the Company received a Civil Investigative Demand, or CID, from the United States Attorney for the Northern District of California in connection with an investigation under the False Claims Act. The CID requests information and documents regarding billing of government-funded programs for the Company’s panel of genetic tests known as Guardant360. The Company is fully cooperating with the investigation. At this time, the Company is unable to predict the outcome of this investigation.

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Common Stock

3 Months Ended

Mar. 31, 2022

Equity [Abstract]

Common Stock

Common StockThe Company’s common stockholders are entitled to dividends if and when declared by the Company’s Board of Directors, or the Board of Directors. As of March 31, 2022, and December 31, 2021, no dividends on the Company's common stock had been declared by the Board of Directors.

The Company’s common stock has been reserved for the following potential future issuances:

	March 31, 2022	December 31, 2021
	(unaudited)
Shares underlying outstanding stock options	2,509,506	2,624,974
Shares underlying unvested restricted stock units	1,506,378	1,498,553
Market-based restricted stock units	2,260,764	2,260,764
Performance-based restricted stock units	345,082	374,596
Shares available for issuance under the 2018 Incentive Award Plan	8,925,158	5,231,624
Shares available for issuance under the 2018 Employee Stock Purchase Plan	1,426,264	1,426,264
Total	16,973,152	13,416,775

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Stock-Based Compensation

3 Months Ended

Mar. 31, 2022

Share-based Payment Arrangement [Abstract]

Stock-Based Compensation

Stock-Based Compensation

Stock Option Activity

A summary of the Company’s stock option activity under the 2012 Stock Plan (as amended and restated), or the 2012 Plan, and the 2018 Incentive Award Plan, or the 2018 Plan, and related information is as follows:

		Options Outstanding
	Shares Available for Grant	Shares Subject to Options Outstanding	Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (Years)	Aggregate Intrinsic Value
	(unaudited)
						(in thousands)
Balance as of January 1, 2022	5,231,624	2,624,974	$	29.17	6.5	$	193,014
2018 Plan annual increase(1)	3,689,000	—
Granted	(7,252)	7,252	62.10
Exercised	—	(105,218)	5.94
Canceled	13,268	(17,502)	74.71
Restricted stock units granted	(128,855)	—	—
Restricted stock units canceled	97,859	—	—
Performance-based restricted stock units canceled	29,514	—	—
Balance as of March 31, 2022	8,925,158	2,509,506	$	29.92	6.3	$	115,462
Vested and Exercisable as of March 31, 2022		1,957,910	$	12.56	5.6	$	109,604

(1)Effective as of January 1, 2022, an additional 3,689,000 shares of common stock became available for issuance under the 2018 Plan, as a result of the operation of an automatic annual increase provision therein.

Aggregate intrinsic value represents the difference between the estimated fair value of the underlying common stock and the exercise price of outstanding, in-the-money options. The total intrinsic value of the options exercised was $7.3 million and $38.3 million for the three months ended March 31, 2022, and 2021, respectively.

The weighted-average grant date fair value of options granted was $36.32 and $101.21 per share for the three months ended March 31, 2022, and 2021, respectively.

Future stock-based compensation for unvested options as of March 31, 2022 was $27.9 million, which is expected to be recognized over a weighted-average period of 2.9 years.

Restricted Stock Units

A summary of the Company’s restricted stock unit activity excluding the performance-based and market-based restricted stock units under the 2012 Plan and the 2018 Plan and related information is as follows:

	Restricted Stock Units Outstanding	Weighted-Average Grant Date Fair Value
	(unaudited)
Balance as of January 1, 2022	1,498,553	$	109.72
Granted	128,855	62.10
Vested and released	(23,171)	105.58
Canceled	(97,859)	108.53
Balance as of March 31, 2022	1,506,378	$	105.78

Future stock-based compensation for unvested restricted stock units as of March 31, 2022 was $130.1 million, which is expected to be recognized over a weighted-average period of 3.0 years.

Performance-based Restricted Stock Units

Since November 2020, the Compensation Committee of the Board of Directors started to approve, and the Company started to grant performance-based restricted stock units, or PSUs, under the 2018 Plan. The PSUs granted to employees consist of financial and operational metrics to be met over a performance period of 4 years and an additional service period requirement of six months after the performance metrics are met. The PSUs granted to a consultant consistent of operational metrics to be met over a performance period of 4 years. The PSUs are expected to be expensed over a period of approximately 4 years to 4.5 years subject to meeting the respective performance metrics and service requirements. As of March 31, 2022, a significant portion of these PSUs are not expected to achieve the related performance metrics, and therefore, no stock-based compensation expense was recorded for the PSUs that were not probable to vest.

A summary of the Company’s performance-based restricted stock unit activity under the 2018 Plan and related information is as follows:

	Performance-based Restricted Stock Units Outstanding	Weighted-Average Grant Date Fair Value
	(unaudited)
Balance as of January 1, 2022	374,596	$	116.58
Canceled	(29,514)	113.40
Balance as of March 31, 2022	345,082	$	116.86

Stock-based compensation recorded for the PSUs was $0.3 million and $0.3 million for the three months ended March 31, 2022, and 2021, respectively. Future stock-based compensation for unvested PSUs that are probable to vest as of March 31, 2022 was $3.5 million, which is expected to be recognized over a weighted-average period of 2.9 years.

Market-based Restricted Stock Units

In May 2020, the Board of Directors approved and granted 1,695,574 market-based restricted stock units, or MSUs, under the 2018 Plan to each of the Company's Co-Chief Executive Officers, which is subject to the achievement of market-based share price goals established by the Board of Directors. The MSUs consist of three separate tranches and the vesting of each tranche is subject to the Company's common stock closing price being maintained at or above a predetermined share price goal for a period of 30 consecutive calendar days. The share price goal can be met any time during the seven-year performance period from the date of grant. Upon vesting, the MSUs must be held for a period of six to twelve months depending on the time of vesting within the seven-year performance period. The vesting of the MSUs can also be triggered upon a change in control event and achievement of a certain change in

control price goal, or when there is a qualifying termination or in the event of death or disability. The following table presents additional information relating to each MSU award:

Tranche	Price Goal	Number of RSUs
Tranche 1	$120 per share	565,192
Tranche 2	$150 per share	565,191
Tranche 3	$200 per share	565,191

The grant date fair values of the MSUs were determined using a Monte Carlo valuation model for each tranche. The related stock-based compensation expense for each tranche is recognized based on an accelerated attribution method over the estimated derived service period. If the related share price goal is achieved earlier than its expected derived service period, the stock-based compensation expense will be recognized as a cumulative catch-up expense from the grant date to that point in time in achieving the share price goal. The derived service period is the median duration of the successful stock price paths to meet the price goal for each tranche as simulated in the Monte Carlo valuation model. The Monte Carlo valuation model uses assumptions such as volatility, risk-free interest rate, cost of equity and dividend estimated for the performance period of the MSU. The weighted-average grant date fair value of the MSUs was $67.00 per share and the weighted-average derived service period was estimated to be in the range of 0.83 – 2.07 years.

On January 1, 2021, Tranche 1 of the MSUs became vested because it had met both service requirement and market-based performance metrics as the predetermined share price goal of $120 per share was achieved for a period of 30 consecutive calendar days. As of March 31, 2022 and December 31, 2021, 2,260,764 shares of market-based restricted stock units, with a weighted-average grant date fair value of $65.20 per share, were outstanding under the 2018 Plan. No MSUs were granted, vested or canceled during the three months ended March 31, 2022.

Stock-based compensation for the MSUs was $8.5 million and $43.9 million, for the three months ended March 31, 2022, and 2021, respectively, which was recorded in general and administrative expenses on the Company's condensed consolidated statement of operations. Future stock-based compensation for unvested MSUs as of March 31, 2022 was $7.6 million, which is expected to be recognized over a weighted-average period of 0.2 years. In the event of a change in control, a qualifying termination, death, disability or the share price goal occurring earlier than the estimated derived service period, the stock-based compensation relating to these MSUs could be accelerated. Any MSUs that remain unvested at the end of the seven-year performance period will automatically be forfeited and terminated without further consideration.

AMEA 2020 Equity Incentive Plan

In August 2020, the board of directors of the Joint Venture approved its 2020 Equity Incentive Plan, or the AMEA 2020 Plan, under which the Joint Venture may grant equity incentive awards such as stock options, restricted stock, restricted stock units, stock appreciation rights and cash-based awards to its employees and non-employees. Stock options granted may be either incentive stock options or nonstatutory stock options. Incentive stock options may be granted only to employees of the Joint Venture or its affiliates. Nonstatutory stock options may be granted to employees, directors and non-employee consultants. Stock options may be granted at an exercise price of not less than the fair market value of the Joint Venture's common stock on the date of grant, determined by the board of directors of the Joint Venture. Options generally vest over 4 years and expire as determined by the board of directors of the Joint Venture, provided that the term of options may not exceed 10 years from the date of grant. For individuals holding more than 10% of the total combined voting power of all classes of stock of the Joint Venture, the exercise price of an option will not be less than 110% of the fair market value of the Joint Venture's common stock on the date of grant, and the term of the option will not exceed 5 years. A total of 4,595,555 shares of the Joint

Venture's Class B common stock are initially reserved for issuance under the AMEA 2020 Plan, and the number of shares may be increased in accordance with the terms of the AMEA 2020 Plan.

A summary of the Joint Venture's stock option activity under the AMEA 2020 Plan and related information is as follows:

		Options Outstanding
	Shares Available for Grant	Shares Subject to Options Outstanding	Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (Years)	Aggregate Intrinsic Value
	(unaudited)
						(in thousands)
Balance as of January 1, 2022	340,928	3,652,219	$	0.58	8.8	$	—
Exercised	—	(582,020)	0.58
Canceled	74,999	(74,999)	0.58
Balance as of March 31, 2022	415,927	2,995,200	$	0.58	8.6	$	—
Vested and Exercisable as of March 31, 2022		1,809,430	$	0.58	8.4	$	—

No stock options were granted under the AMEA 2020 Plan for the three months ended March 31, 2022. The weighted-average grant date fair value of options granted under the AMEA 2020 Plan was $0.33 per share for the three months ended March 31, 2021. Future stock-based compensation for unvested options as of March 31, 2022 was $0.3 million, which is expected to be recognized over a weighted-average period of 2.4 years.

Stock-Based Compensation Expense

The following table presents the effect of employee and non-employee related stock-based compensation expense including the Joint Venture:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
Cost of precision oncology testing	$	1,164	$	767
Research and development expense	5,343		4,300
Sales and marketing expense	5,525		2,880
General and administrative expense	12,767		47,122
Total stock-based compensation expense	$	24,799	$	55,069

Valuation of Stock Options

The grant date fair value of stock options was estimated using a Black-Scholes option-pricing model with the following weighted-average assumptions including the Joint Venture:

	Three Months Ended March 31,
	2022	2021
	(unaudited)
Expected term (in years)	5.97	6.01 – 6.04
Expected volatility	63.3%	63.6% – 66.4%
Risk-free interest rate	1.9%	0.3% – 0.8%
Expected dividend yield	—%	—%

The determination of the fair value of stock options on the date of grant using a Black-Scholes option-pricing model is affected by the estimated fair value of common stock of the Company and the Joint Venture, as well as assumptions regarding a number of variables that are complex, subjective and generally require significant judgment to determine. The valuation assumptions were determined as follows:

Fair Value of Common Stock

The fair value of the Company’s common stock is determined by the closing price, on the date of grant, of its common stock, which is traded on the Nasdaq Global Select Market. The grant date fair value of the Joint Venture's common stock has been determined by the board of directors of the Joint Venture. The grant date fair value of the Joint Venture’s common stock was determined using valuation methodologies which utilize certain assumptions including probability weighting of events, volatility, time to liquidation, a risk-free interest rate and an assumption for a discount for lack of marketability. In determining the fair value of the Joint Venture’s common stock, the methodologies used to estimate the enterprise value of the Joint Venture were performed using methodologies, approaches, and assumptions consistent with the American Institute of Certified Public Accountants Accounting and Valuation Guide, Valuation of Privately-Held-Company Equity Securities Issued as Compensation.

Expected Term

The expected term represents the period that the options granted are expected to be outstanding and is determined using the simplified method (based on the mid-point between the vesting date and the end of the contractual term) as the Company has concluded that its stock option exercise history does not provide a reasonable basis upon which to estimate expected term.

Expected Volatility

Prior to the commencement of trading of the Company’s common stock on the Nasdaq Global Select Market on October 4, 2018 in connection with the IPO, there was no active trading market for the Company's common stock. Due to limited historical data for the trading of the Company’s common stock, expected volatility is estimated based on the average volatility for comparable publicly traded peer group companies in the same industry plus the Company's expected volatility for the available periods. The comparable companies are chosen based on their similar size, stage in the life cycle or area of specialty.

The Joint Venture derived the expected volatility from the average historical volatility over a period approximately equal to the expected term of comparable publicly traded companies within its peer group that were deemed to be representative of future stock price trends as the Joint Venture does not have any trading history for its common stock. The Joint Venture will continue to apply this process until a sufficient amount of historical information regarding the volatility of its own stock price becomes available.

Risk-Free Interest Rate

The risk-free interest rate is based on the U.S. Treasury rate, with maturities similar to the expected term of the stock options.

Expected Dividend Yield

The Company and the Joint Venture does not anticipate paying any dividends in the foreseeable future and, therefore, uses an expected dividend yield of zero.

2018 Employee Stock Purchase Plan

In September 2018, the Company’s Board of Directors adopted and its stockholders approved the 2018 Employee Stock Purchase Plan, or the ESPP. A total of 922,250 shares of common stock were initially reserved for issuance under the ESPP. Effective as of January 1, 2020, an additional 942,614 shares of common stock became available for issuance under the ESPP.

Subject to any plan limitations, the ESPP allows eligible employees to contribute, normally through payroll deductions, up to 10% of their earnings for the purchase of the Company’s common stock at a discounted price per share. The price at which common stock is purchased under the ESPP is equal to 85% of the fair market value of the Company’s common stock on the first or last day of the offering period, whichever is lower. The ESPP provides for separate six-month offering periods beginning on May 15 and November 15 of each year.

No ESPP shares were granted or purchased for the three months ended March 31, 2022 and 2021. The total compensation expense related to the ESPP was $1.0 million and $0.8 million for the three months ended March 31, 2022, and 2021, respectively.

The fair value of the stock purchase right granted under the ESPP was estimated on the first day of each offering period using the Black-Scholes option pricing model. The valuation assumptions used were substantially consistent with the assumption used to value stock options with the exception of the expected term which was based on the term of each purchase period.

As of March 31, 2022, the unrecognized stock-based compensation expense related to the ESPP was $0.5 million, which is expected to be recognized over the remaining term of the offering period of 0.1 years.

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Net Loss Per Share Attributable to Guardant Health, Inc. Common Stockholders

3 Months Ended

Mar. 31, 2022

Earnings Per Share [Abstract]

Net Loss Per Share Attributable to Guardant Health, Inc. Common Stockholders

Net Loss Per Share Attributable to Guardant Health, Inc. Common Stockholders

The following table sets forth the computation of the basic and diluted net loss per share attributable to Guardant Health, Inc. common stockholders:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands, except per share data)
Net loss	$	(123,228)	$	(107,358)
Adjustment of redeemable noncontrolling interest	—		(2,300)
Net loss attributable to Guardant Health, Inc. common stockholders, basic and diluted	$	(123,228)	$	(109,658)
Net loss per share attributable to Guardant Health, Inc. common stockholders, basic and diluted	$	(1.21)	$	(1.09)
Weighted-average shares used in computing net loss per share attributable to Guardant Health, Inc. common stockholders, basic and diluted	101,853		100,955

Since the Company was in a loss position for all periods presented, basic net loss per share attributable to Guardant Health, Inc. common stockholders is the same as diluted net loss per share attributable to Guardant Health, Inc. common stockholders, as the inclusion of all potential shares of common stock outstanding would have been anti-dilutive. The following weighted-average common stock equivalents were excluded from the calculation of diluted net loss per share attributable to Guardant Health, Inc. common stockholders for the periods presented as they had an anti-dilutive effect:

	Three Months Ended March 31,
	2022	2021
	(unaudited)
	(in thousands)
Stock options issued and outstanding (1)	2,550	2,912
Restricted stock units	1,484	1,120
MSUs	2,261	2,646
PSUs	357	407
ESPP obligation	84	47
Common stock subject to repurchase	—	11
Convertible senior notes	8,225	8,225
Total	14,961	15,368

(1)    Excludes outstanding stock options to purchase 2,995,200 shares of the Joint Venture's Class B common stock under the AMEA 2020 Plan as of March 31, 2022.

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Income Taxes	3 Months Ended
	Mar. 31, 2022
Income Tax Disclosure [Abstract]
Income Taxes	Income TaxesThe income tax expense for the three months ended March 31, 2022 was determined based upon estimates of the Company’s effective income tax rates in various jurisdictions. The difference between the Company’s effective income tax rate and the U.S. federal statutory rate is primarily attributable to state income taxes, foreign income taxes, the effect of certain permanent differences, and full valuation allowance against net deferred tax assets.The income tax expense for the three months ended March 31, 2022, and 2021, relates primarily to state minimum income tax and income tax on the Company’s earnings in foreign jurisdictions.

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Segment and Geographic Information

3 Months Ended

Mar. 31, 2022

Segment Reporting [Abstract]

Segment and Geographic Information

Segment and Geographic Information

The Company operates as one operating segment. The Company's chief operating decision makers are its Co-Chief Executive Officers, who review financial information presented on a consolidated basis for the purposes of making operating decisions, assessing financial performance and allocating resources.

The following table sets forth the Company’s revenue by geographic areas based on the customers’ locations:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
United States	$	90,871	$	72,300
International (1)	5,228		6,365
Total revenue	$	96,099	$	78,665

(1)    No single country outside of the United States accounted for more than 10% of total revenue during the three months ended March 31, 2022, and 2021, respectively.

As of March 31, 2022, and December 31, 2021, 98% and 98%, respectively, of the Company’s long-lived assets and right-of-use assets are located in the United States.

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Related Party Transactions

3 Months Ended

Mar. 31, 2022

Related Party Transactions [Abstract]

Related Party Transactions

Related Party Transactions

As discussed in Note 3, Investment in Joint Venture, the Company and an affiliate of SoftBank formed and capitalized the Joint Venture to accelerate commercialization of its products in Asia, the Middle East and Africa. The Company has consolidated the financial position, results of operations and cash flows of the Joint Venture in its financial statements and all intercompany balances have been eliminated in consolidation.

The Company and its subsidiaries may, in the ordinary course of business, have transactions with unaffiliated companies of which certain of the Company’s directors are directors and/or executive officers. The Company believes that such transactions are on the same terms generally offered by such other companies to other entities in comparable transactions. The Company does not consider the amounts involved in such transactions to be material in relation to its businesses, the businesses of such other companies or the interests of the directors involved.

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Summary of Significant Accounting Policies (Policies)

3 Months Ended

Mar. 31, 2022

Accounting Policies [Abstract]

Basis of Presentation

Basis of Presentation

The Company’s condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America, or GAAP. The accompanying condensed consolidated financial statements include the accounts of Guardant Health, Inc., its consolidated Joint Venture and majority owned subsidiaries. Other stockholders’ interests in the Joint Venture are shown in the condensed consolidated financial statements as noncontrolling interest liability. All significant intercompany balances and transactions have been eliminated in consolidation.

The Company believes that its existing cash and cash equivalents and marketable securities as of March 31, 2022, will be sufficient to allow the Company to fund its current operating plan through at least a period of one year after the date the accompanying condensed consolidated financial statements are issued. As the Company continues to incur losses, its transition to profitability is dependent upon a level of revenues adequate to support the Company’s cost structure. If the Company’s transition to profitability is not consistent with its current operating plan, the Company may have to seek additional capital.

Use of Estimates

Use of Estimates

The preparation of condensed consolidated financial statements in conformity with GAAP requires management to make certain estimates, judgments and assumptions that affect the reported amounts of assets and liabilities and the related disclosures at the date of the condensed consolidated financial statements, as well as the reported amounts of revenues and expenses during the periods presented. The Company bases its estimates on historical experience and other market-specific or other relevant assumptions that it believes to be reasonable under the circumstances. Estimates are used in several areas including, but not limited to, estimation of variable consideration, estimation of credit losses, standalone selling price allocation included in contracts with multiple performance obligations,

goodwill and identifiable intangible assets, stock-based compensation, incremental borrowing rate for operating leases, contingencies, certain inputs into the provision for (benefit from) income taxes, including related reserves, valuation of non-marketable securities, valuation of redeemable noncontrolling interest and noncontrolling interest liability, among others. These estimates generally involve complex issues and require judgments, involve the analysis of historical results and prediction of future trends, can require extended periods of time to resolve and are subject to change from period to period. Actual results may differ materially from management’s estimates. The severity of the impact on the Company's business for the remainder of calendar year 2022 and beyond will depend on a number of factors, including, but not limited to, the duration and severity of the pandemic, and the impact of any variants of the virus, the extent and severity of the impact on the Company's customers and suppliers, the continued disruption to demand for the Company's products and services, and the impact of the global business and economic environment on liquidity and the availability of capital, all of which are uncertain and cannot be predicted.

Unaudited Interim Condensed Financial Statements

Unaudited Interim Condensed Financial Statements

The accompanying condensed consolidated balance sheet as of March 31, 2022, the condensed consolidated statements of operations for the three months ended March 31, 2022, and 2021, the condensed consolidated statements of comprehensive loss for the three months ended March 31, 2022, and 2021, the condensed consolidated statements of redeemable noncontrolling interest and stockholders’ equity for the three months ended March 31, 2022, and 2021, and cash flows for the three months ended March 31, 2022, and 2021, and the related interim condensed consolidated disclosures are unaudited. The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with GAAP for interim financial information and in accordance with the instructions to Form 10-Q and Rule 10-01 of Regulation S-X of the Securities Act of 1933, as amended, or the Securities Act. Accordingly, they do not include all of the information and notes required by GAAP for complete financial statements. These unaudited condensed consolidated financial statements include all adjustments, consisting only of normal recurring accruals that the Company believes are necessary to fairly state the financial position and the results of the Company’s operations and cash flows for interim periods in accordance with GAAP. Interim-period results are not necessarily indicative of results of operations or cash flows for a full year or any subsequent interim period.

The accompanying condensed consolidated financial statements should be read in conjunction with the Company’s audited financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021.

Foreign Currency

Foreign Currency The functional currency of the subsidiaries of the consolidated Joint Venture is the local currency. The assets and liabilities of the subsidiaries are translated into U.S. dollars at exchange rates in effect at each balance sheet date, with the resulting translation adjustments recorded to a separate component of accumulated other comprehensive loss within stockholders’ equity. Income and expense accounts are translated at average exchange rates during the period. Foreign currency transaction gains and losses resulting from transactions denominated in a currency other than the functional currency are recognized in the condensed consolidated statements of operations.

Restricted Cash

Restricted CashRestricted cash consists of payroll withholding related to the Company's enrollment in certain voluntary disability insurance plan.

Non-Marketable Securities

Non-Marketable Securities

The Company acquires certain equity investments in private companies to promote business and strategic objectives. The Company's investments in non-marketable equity securities do not give the Company the ability to control or exercise significant influence over the investee. The Company's non-marketable equity and other related investments totaled $52.2 million and $39.4 million as of March 31, 2022, and December 31, 2021, respectively, and are included in other assets, net on the accompanying condensed consolidated balance sheets. Non-marketable securities are subject to periodic impairment reviews and adjustments for observable price changes from orderly transactions. The Company's evaluation of impairment of such non-marketable securities is based on adverse changes in market conditions and the regulatory or economic environment, qualitative and quantitative analysis of the operating performance of the investee; changes in operating structure or management of the investee; additional funding requirements; and the investee’s ability to remain in business. Pursuant to one of the investments in non-marketable

securities purchased by the Company, the Company acquired rights to purchase the investee at a pre-determined price subject to additional adjustments based on the performance of the investee, on or before December 31, 2022. As of March 31, 2022, no impairment or downward adjustments to the carrying value of non-marketable securities have been recorded. The Company’s assessment of these factors in determining whether an impairment exists could change in the future due to new developments or changes in applied assumptions.

Concentration of Risk

Concentration of Risk

The Company is subject to credit risk from its portfolio of cash equivalents held at one commercial bank and investments in marketable securities. The Company limits its exposure to credit losses by investing in money market funds through a U.S. bank with high credit ratings. The Company’s cash may consist of deposits held with banks that may at times exceed federally insured limits, however, its exposure to credit risk in the event of default by the financial institution is limited to the extent of amounts recorded on the condensed consolidated balance sheets. The Company performs evaluations of the relative credit standing of these financial institutions to limit the amount of credit exposure.

The Company also invests in investment-grade debt instruments and has policy limits for the amount it can invest in any one type of security, except for securities issued or guaranteed by the U.S. government. The goals of the Company’s investment policy, in order of priority, are as follows: safety and preservation of principal and diversification of risk; liquidity of investments sufficient to meet cash flow requirements; and a competitive after-tax rate of return. Under its investment policy, the Company limits amounts invested in such securities by credit rating, maturity, investment type and issuer, as a result, the Company is not exposed to any significant concentrations of credit risk from these financial instruments.

The Company is subject to credit risk from its accounts receivable. The majority of the Company’s accounts receivable arises from the provision of precision oncology services and development services and other in the United States and are primarily with biopharmaceutical companies with high credit ratings. The Company has not experienced any material losses related to receivables from individual customers, or groups of customers. The Company does not require collateral. Accounts receivable are recorded at net amount.

The Company is also subject to credit risk from its other receivables and other assets.

Accounts Receivable, Net

Accounts Receivable, Net

Accounts receivable represent valid claims against commercial and governmental payers, biopharmaceutical companies, research institutes and international distributors, including unbilled receivables, and royalty payments due from third parties for licensing the Company’s technologies. Unbilled receivables include balances due from biopharmaceutical customers related to development services and other revenues that are recognized upon the achievement of performance-based milestones but prior to the achievement of contractual billing rights. As of March 31, 2022, and December 31, 2021, the Company had unbilled receivables of $3.1 million and $5.7 million, respectively.

The Company evaluates the collectability of its accounts receivable based on historical collection trends, the financial condition of payment partners, and external market factors and provides for an allowance for potential credit losses based on management’s best estimate of the amount of probable credit losses. As of March 31, 2022, and December 31, 2021, the Company had immaterial allowance for credit losses related to its accounts receivable.

Asset Acquisition

Asset Acquisition

If an acquisition of an asset or group of assets does not meet the definition of a business, the transaction is accounted for as an asset acquisition rather than a business combination. An asset acquisition does not result in the recognition of goodwill and transaction costs are capitalized as part of the cost of the asset or group of assets acquired. Transaction costs allocated to in-process research and development technology with no future alternate use is expensed as incurred. The total consideration is allocated to the various intangible assets acquired on a relative fair value basis. Cash paid in connection of purchase of in-process research and development technology in an asset acquisition is presented within the investing section of the condensed consolidated statement of cash flows.

Goodwill and Intangible Assets, net

Goodwill and Intangible Assets, net

Intangible assets related to in-process research and development costs, or IPR&D, acquired in a business combination are considered to be indefinite-lived until the completion or abandonment of the associated research

and development efforts. If and when development is complete, the associated assets would be deemed finite-lived and would then be amortized based on their respective estimated useful lives at that point in time. Prior to completion of the research and development efforts, the assets are considered indefinite-lived. During this period, the assets will not be amortized but will be tested for impairment on an annual basis and between annual tests if the Company becomes aware of any events occurring or changes in circumstances that would indicate a reduction in the fair value of the IPR&D projects below their respective carrying amounts.

Goodwill represents the excess of the purchase price over the fair value of net identifiable assets and liabilities. Goodwill and IPR&D are not amortized but are tested for impairment at least annually during the fourth fiscal quarter, or if circumstances indicate their value may no longer be recoverable. The Company continues to operate in one segment, which is considered to be the sole reporting unit and, therefore, goodwill was tested for impairment at the enterprise level. As of March 31, 2022, there has been no impairment of goodwill or IPR&D.

Intangible assets are carried at cost, net of accumulated amortization. The Company does not have intangible assets with indefinite useful lives other than goodwill and the acquired IPR&D. Amortization is recorded on a straight-line basis over the intangible asset's useful life, which is approximately 6—12 years.

Post-acquisition Contingent Consideration

Post-acquisition Contingent Consideration Post-acquisition contingent consideration is recognized over the service period, subject to meeting the respective service requirements and performance metrics.

Leases

Leases

The Company determines if an arrangement contains a lease at inception. Operating lease right-of-use, or ROU, assets and operating leases liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. ROU assets also include any initial direct costs incurred and any lease payments made at or before the lease commencement date, less lease incentives received or receivable. The Company uses its incremental borrowing rate based on the information available at the commencement date in determining the lease liabilities, as the Company's leases generally do not provide an implicit rate. Lease terms may include options to extend or terminate when the Company is reasonably certain the option will be exercised. Lease expense is recognized on a straight-line basis over the lease term. The Company also has lease arrangements with lease and non-lease components. The Company elected the practical expedient not to separate non-lease components from lease components for the Company’s facility leases. The Company also elected to apply the short-term lease measurement and recognition exemption in which ROU assets and lease liabilities are not recognized for leases with terms of 12 months or less.

Convertible Senior Notes

Convertible Senior Notes

Upon early adoption of ASU 2020-06, Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity on January 1, 2021, the Company reclassified the carrying amount of the equity component of the cash conversion feature including the allocated debt issuance costs from additional paid-in capital to convertible senior notes, net. Convertible senior notes are accounted for as a liability and measured at their amortized cost. Transaction costs related to the issuance of the notes are netted with the liability and are amortized to interest expense over the term of the notes, using an effective interest rate method.

Revenue Recognition

Revenue Recognition

The Company derives revenue from the provision of precision oncology testing services provided to its ordering physicians and biopharmaceutical customers, as well as from biopharmaceutical research and development services provided to its biopharmaceutical customers. Precision oncology testing services include genomic profiling and the delivery of other genomic information derived from the Company’s platform. Development services and other include companion diagnostic development, clinical study setup, monitoring and maintenance, information solutions and laboratory services, and other miscellaneous revenue streams. The Company currently receives payments from third-party commercial and governmental payers, certain hospitals and oncology centers and individual patients, as well as biopharmaceutical companies, research institutes and international distributors.

Revenues are recognized when control of services is transferred to customers, in an amount that reflects the consideration the Company expects to be entitled to in exchange for those services. ASC 606 provides for a five-step model that includes identifying the contract with a customer, identifying the performance obligations in the contract,

determining the transaction price, allocating the transaction price to the performance obligations, and recognizing revenue when, or as, an entity satisfies a performance obligation.

Precision oncology testing

The Company recognizes revenue from the sale of its precision oncology tests for clinical customers, including certain hospitals, cancer centers, other institutions and patients, at the time results of the test are reported to physicians. Most precision oncology tests requested by clinical customers are sold without a written agreement; however, the Company determines an implied contract exists with its clinical customers. The Company identifies each sale of its test to a clinical customer as a single performance obligation. With the exception of certain limited contracted arrangements with insurance carriers and other institutions where the transaction price is fixed, a stated contract price does not exist and the transaction price for each implied contract with clinical customers represents variable consideration. The Company estimates the variable consideration under the portfolio approach and considers the historical reimbursement data from third-party commercial and governmental payers and patients, as well as known or anticipated reimbursement trends not reflected in the historical data. The Company monitors the estimated amount to be collected in the portfolio at each reporting period based on actual cash collections in order to assess whether a revision to the estimate is required. Both the estimate and any subsequent revision contain uncertainty and require the use of significant judgment in the estimation of the variable consideration and application of the constraint for such variable consideration. The Company analyzes its actual cash collections over the expected reimbursement period and compares it with the estimated variable consideration for each portfolio and any difference is recognized as an adjustment to estimated revenue after the expected reimbursement period, subject to assessment of the risk of future revenue reversal. For the three months ended March 31, 2022, and 2021, the Company recorded $2.0 million and $5.1 million as revenue, respectively, resulting from cash collections exceeding the estimated variable consideration related to samples processed in previous periods, including revenue received from successful appeals of reimbursement denials, net of recoupments.

Revenue from sales of precision oncology tests to biopharmaceutical customers are based on a negotiated price per test or on the basis of an agreement to provide certain testing volume over a defined period. The Company identifies its promise to transfer a series of distinct tests to biopharmaceutical customers as a single performance obligation. Precision oncology tests to biopharmaceutical customers are generally billed at a fixed price for each test performed. For agreements involving testing volume to be satisfied over a defined period, revenue is recognized over time based on the number of tests performed as the performance obligation is satisfied over time. Results of the Company’s precision oncology services are delivered electronically, and as such there are no shipping or handling fees incurred by the Company or billed to customers.

Development services and other

The Company performs development services for its biopharmaceutical customers utilizing its precision oncology information platform. Development services typically represent a single performance obligation as the Company performs a significant integration service, such as analytical validation and regulatory submissions. The individual promises are not separately identifiable from other promises in the contracts and, therefore, are not distinct. However, under certain contracts, a biopharmaceutical customer may engage the Company for multiple distinct development services which are both capable of being distinct and separately identifiable from other promises in the contracts and, therefore, distinct performance obligations.

The Company collaborates with pharmaceutical companies in the development of new drugs. As part of these collaborations, the Company provides services related to regulatory filings to support companion diagnostic device submissions for the Company’s testing panels. Under these collaborations, the Company generates revenue from achievement of milestones, as well as provision of on-going support. For development services performed, the Company is compensated through a combination of an upfront fee and performance-based, non-refundable regulatory and other developmental milestone payments. The transaction price of the Company's development services contracts typically represents variable consideration. Application of the constraint for variable consideration to milestone payments is an area that requires significant judgment. The Company evaluates factors such as the scientific, clinical, regulatory, commercial, and other risks that must be managed to achieve the respective milestone and the level of effort and investment required to achieve the respective milestone. In making this assessment, the Company considers its historical experience with similar milestones, the degree of complexity and uncertainty associated with each milestone, and whether achievement of the milestone is dependent on parties other than the Company. The constraint for variable consideration is applied such that it is probable a significant reversal of revenue will not occur when the uncertainty associated with the contingency is resolved. Application of the constraint for variable consideration is assessed and updated at each reporting period as a revision to the estimated transaction price.

The Company recognizes development services revenue over the period in which biopharmaceutical research and development services are provided. Specifically, the Company recognizes revenue using an input method to measure progress, utilizing costs incurred to-date relative to total expected costs as its measure of progress. The Company assesses the changes to the total expected cost estimates as well as any incremental fees negotiated resulting from changes to the scope of the original contract in determining the revenue recognition at each reporting period. For development of new products or services under these arrangements, costs incurred before technological feasibility is reached are included as research and development expenses in the Company’s condensed consolidated statements of operations, while costs incurred thereafter are recorded as cost of development services and other.

The Company also has other miscellaneous revenue streams that are recognized in addition to development services noted above such as clinical study setup, monitoring and maintenance, testing development and support, GuardantConnect, GuardantINFORM, and kits fulfillment related revenues. Revenues related to clinical study setup, monitoring and maintenance, testing development and support, GuardantConnect, and GuardantINFORM are generally recognized over time based on an input method to measure progress in the period when the associated services have been performed. Kits fulfillment related revenues are recognized when such products are delivered. In addition, the Company derives sales-based royalty revenues from licensing its technologies. Royalty revenues are recognized in the period when royalty-bearing sales occur.

Contracts with multiple performance obligations

Contracts with biopharmaceutical customers may include multiple distinct performance obligations, such as provision of precision oncology testing, biopharmaceutical research and development services, and clinical study enrollment assistance, among others. The Company evaluates the terms and conditions included within its contracts with biopharmaceutical customers to ensure appropriate revenue recognition, including whether services are considered distinct performance obligations that should be accounted for separately versus together. The Company first identifies material promises, in contrast to immaterial promises or administrative tasks, under the contract, and then evaluates whether these promises are both capable of being distinct and distinct within the context of the contract. In assessing whether a promised service is capable of being distinct, the Company considers whether the customer could benefit from the service either on its own or together with other resources that are readily available to the customer, including factors such as the research, development, and commercialization capabilities of a third party as well as the availability of the associated expertise in the general marketplace. In assessing whether a promised service is distinct within the context of the contract, the Company considers whether it provides a significant integration of the services, whether the services significantly modify or customize one another, or whether the services are highly interdependent or interrelated.

For contracts with multiple performance obligations, the transaction price is allocated to the separate performance obligations on a relative standalone selling price basis. The Company determines standalone selling price by considering the historical selling price of these performance obligations in similar transactions as well as other factors, including, but not limited to, the price that customers in the market would be willing to pay, competitive pricing of other vendors, industry publications and current pricing practices, and expected costs of satisfying each performance obligation plus appropriate margin.

Deferred revenue

Deferred revenue, which is a contract liability, consists primarily of payments received in advance of revenue recognition from contracts with customers. For example, development services and other contracts with biopharmaceutical customers often contain upfront payments which results in the recording of deferred revenue to the extent cash is received prior to the Company's performance of the related services. Contract liabilities are relieved as the Company performs its obligations under the contract and revenue is consequently recognized. As of March 31, 2022, and December 31, 2021, the deferred revenue balance was $10.6 million and $11.3 million, respectively. Revenue recognized in the three months ended March 31, 2022 that was included in the deferred revenue balance as of December 31, 2021 was $3.5 million, and revenue recognized in the three months ended March 31, 2021 that was included in the deferred revenue balance as of December 31, 2020 was $5.0 million, respectively.

Transaction price allocated to the remaining performance obligations

Transaction price allocated to remaining performance obligations represents contracted revenue that has not yet been recognized, which includes deferred revenue and non-cancelable amounts that will be invoiced and recognized as revenues in future periods. The Company expects to recognize substantially all of the remaining transaction price in the next 12 months.

Costs of Precision Oncology Testing

Costs of Precision Oncology Testing

Cost of precision oncology testing generally consists of cost of materials, direct labor including bonus, benefit and stock-based compensation, equipment and infrastructure expenses associated with processing test samples (including sample accessioning, library preparation, sequencing, quality control analyses and shipping charges to transport blood samples), freight, curation of test results for physicians and license fees due to third parties. Infrastructure expenses include depreciation of laboratory equipment, rent costs, amortization of leasehold improvements and information technology costs. Costs associated with performing the Company’s tests are recorded as the tests are performed regardless of whether revenue was recognized with respect to that test. Royalties for licensed technology calculated as a percentage of revenues generated using the associated technology are recorded as expense at the time the related revenues are recognized. One-time royalty payments related to signing of license agreements or other milestones, such as issuance of new patents, are amortized to expense over the expected useful life of the applicable patent rights.

Cost of Development Services

Cost of Development Services and Other

Cost of development service and other primarily includes costs incurred for the performance of development services requested by the Company’s biopharmaceutical customers and other revenues included as noted above. For development of new products, costs incurred before technological feasibility has been achieved are reported as research and development expenses, while costs incurred thereafter are reported as cost of development services and other.

Research and Development Expenses

Research and Development Expenses

Research and development expenses are comprised of costs incurred to develop technology and include compensation and benefits, reagents and supplies used in research and development laboratory work, infrastructure expenses, including allocated facility occupancy and information technology costs, contract services and other outside costs. Research and development costs are expensed as incurred. Payments made prior to the receipt of goods or services to be used in research and development are deferred and recognized as expense in the period in which the related goods are received or services are rendered. Costs to develop the Company’s technology capabilities are recorded as research and development unless they meet the criteria to be capitalized as internal-use software costs.

Stock-Based Compensation

Stock-Based Compensation

Stock-based compensation related to stock options granted to the Company’s and the Joint Venture's employees, directors and nonemployees is measured at the grant date based on the fair value of the award. The fair value is recognized as expense over the requisite service period, which is generally the vesting period of the respective awards. Compensation expense for stock options with performance metrics is calculated based upon expected achievement of the metrics specified in the grant.

The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock options granted under the 2012 Stock Plan, the 2018 Incentive Award Plan, and the Joint Venture's 2020 Equity Incentive Plan, and stock purchase rights granted under the 2018 Employee Stock Purchase Plan. The Black-Scholes option-pricing model requires assumptions to be made related to the expected term of an award, expected volatility, risk-free rate and expected dividend yield. The board of directors of the Joint Venture has determined the fair value of common stock of the Joint Venture. Forfeitures are accounted for as they occur.

For market-based restricted stock units, the Company derives the requisite service period using the Monte Carlo simulation model and the related compensation expense is recognized over the derived service period using an accelerated attribution model commencing on the grant date. Stock-based compensation expense will be recorded regardless of whether the market conditions are achieved or not. If the related market condition is achieved earlier than its estimated derived service period, the stock-based compensation expense will be accelerated, and a cumulative catch-up expense will be recorded during the period in which the market condition is met.

The Company measures the grant date fair value of its service-based and performance-based restricted stock units issued to employees based on the closing market price of the common stock on the date of grant. For restricted stock units with only service-based vesting conditions, compensation expense is recognized in the Company’s condensed consolidated statement of operations on a straight-line basis over the requisite service period. Compensation expense for restricted stock units with performance metrics is calculated based upon expected achievement of the metrics specified in the grant, and is recognized in the Company’s condensed consolidated statement of operations using an accelerated attribution model over the requisite service period for each separately vesting portion of the award.

Net Loss Per Share Attributable to Common Shareholders

Net Loss Per Share Attributable to Common Stockholders

The Company calculates basic net loss per share attributable to common stockholders by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding for the period. The diluted net loss per share attributable to common stockholders is computed by giving effect to all potential dilutive common stock equivalents outstanding for the period determined using the treasury stock method or the as-if converted method, as appropriate. For purposes of this calculation, stock options, restricted stock units, shares issuable pursuant to the employee stock purchase plan, shares subject to repurchase from early exercised options and contingently issuable shares under the convertible senior notes are considered common stock equivalents but have been excluded from the calculation of diluted net loss per share attributable to common stockholders as their effect is anti-dilutive.

Fair Value Measurements

Financial instruments consist of cash equivalents, marketable securities, accounts receivable, net, prepaid expenses and other current assets, net, accounts payable and accrued expenses. Cash equivalents and marketable securities are stated at fair value. Prepaid expenses and other current assets, net, accounts payable and accrued expenses are stated at their carrying value, which approximates fair value due to the short time to the expected receipt or payment date.

Fair value is defined as the exchange price that would be received from sale of an asset or paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. The identification of market participant assumptions provides a basis for determining what inputs are to be used for pricing each asset or liability. A financial instrument’s classification within the fair value hierarchy is based upon the lowest level of input that is significant to the fair value measurement.

A fair value hierarchy has been established which gives precedence to fair value measurements calculated using observable inputs over those using unobservable inputs. This hierarchy prioritized the inputs into three broad levels as follows:

Level 1 - Quoted prices in active markets for identical assets or liabilities.

Level 2 - Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3 - Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

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Summary of Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2022

Accounting Policies [Abstract]

Schedules of Concentration of Risk, by Risk Factor

A significant customer is a biopharmaceutical customer or a clinical testing payer that represents 10% or more of the Company’s total revenue or accounts receivable balance. Revenue attributable to each significant customer, including its affiliated entities, as a percentage of the Company’s total revenue, for the respective period, and accounts receivable balance attributable to each significant customers, including its affiliated entities, as a percentage of the Company’s total accounts receivable balance, at the respective condensed consolidated balance sheet date, are as follows:

	Revenue				Accounts Receivable, Net
	Three Months Ended March 31,				March 31, 2022		December 31, 2021
	2022		2021
	(unaudited)				(unaudited)
Customer A	30	%	25	%	10	%	13	%
Customer B	*		*		11	%	10	%
Customer C	*		*		*		13	%
Customer D	*		*		16	%	*

*    less than 10%

Schedule of Contractual Receivables and Related Credit Loss

The following table presents the receivable and the related credit loss amounts:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Prepaid expenses and other current assets:
Gross Amount	$	1,100	$	—
Allowance for Credit Losses	(1,100)		—
Net Amount	$	—	$	—
Other assets:
Gross Amount	$	4,800	$	5,900
Allowance for Credit Losses	(4,800)		(5,900)
Net Amount	$	—	$	—

The following table summarizes the allowance for credit losses activities:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
Prepaid expenses and other current assets:
Allowance for credit losses—Beginning of period	$	—	$	—
Reclassification	1,100		1,100
Allowance for credit losses—End of period	$	1,100	$	1,100
Other assets:
Allowance for credit losses—Beginning of period	$	5,900	$	7,000
Reclassification	(1,100)		(1,100)
Allowance for credit losses—End of period	$	4,800	$	5,900

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Condensed Consolidated Balance Sheet Components (Tables)

3 Months Ended

Mar. 31, 2022

Balance Sheet Related Disclosures [Abstract]

Schedule of Property, Plant and Equipment

Property and equipment, net consist of the following:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Machinery and equipment	$	69,583	$	63,022
Leasehold improvements	75,295		38,702
Computer hardware	21,787		16,685
Construction in progress(1)	37,104		55,873
Furniture and fixtures	7,596		3,683
Computer software	1,439		1,320
Property and equipment, gross	$	212,804	$	179,285
Less: accumulated depreciation	(61,482)		(54,824)
Property and equipment, net	$	151,322	$	124,461

(1)    As of March 31, 2022, and December 31, 2021, $16.2 million and $45.8 million of construction in progress was related to leasehold improvements, furniture and equipment for the office in Palo Alto, California, respectively. In February 2022, part of the Palo Alto office was put in service and related construction in progress was transferred to fixed assets.

Schedule of Accrued Liabilities

Accrued expenses consist of the following:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Operating lease liabilities	$	16,556	$	12,856
Accrued tax liabilities	4,401		4,223
Accrued professional services	8,410		6,994
Accrued clinical studies	5,151		3,332
Accrued legal expenses	6,429		4,166
Purchases of property and equipment included in accrued expenses	1,349		5,893
Others	9,555		7,821
Total accrued expenses	$	51,851	$	45,285

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Fair Value Measurements, Cash Equivalents and Marketable Securities (Tables)

3 Months Ended

Mar. 31, 2022

Fair Value Disclosures [Abstract]

Schedule of Fair Value Measurements, Recurring and Nonrecurring

The Company’s financial assets and liabilities subject to fair value measurements on a recurring basis and the level of inputs used in such measurements were as follows:

	March 31, 2022
	Fair Value		Level 1		Level 2		Level 3
	(unaudited)
	(in thousands)
Financial Assets:
Money market funds	$	447,032	$	447,032	$	—	$	—
Total cash equivalents	$	447,032	$	447,032	$	—	$	—
U.S. government debt securities	$	388,662	$	—	$	388,662	$	—
Total short-term marketable securities	$	388,662	$	—	$	388,662	$	—
U.S. government debt securities	$	588,453	$	—	$	588,453	$	—
Total long-term marketable securities	$	588,453	$	—	$	588,453	$	—
Total	$	1,424,147	$	447,032	$	977,115	$	—
Financial Liabilities:
Contingent consideration	$	6,015	$	—	$	—	$	6,015
Total	$	6,015	$	—	$	—	$	6,015

	December 31, 2021
	Fair Value		Level 1		Level 2		Level 3
	(in thousands)
Financial Assets:
Money market funds	$	357,785	$	357,785	$	—	$	—
Total cash equivalents	$	357,785	$	357,785	$	—	$	—
U.S. government debt securities	$	440,546	$	—	$	440,546	$	—
Total short-term marketable securities	$	440,546	$	—	$	440,546	$	—
U.S. government debt securities	$	698,034	$	—	$	698,034	$	—
Total long-term marketable securities	$	698,034	$	—	$	698,034	$	—
Total	$	1,496,365	$	357,785	$	1,138,580	$	—
Financial Liabilities:
Contingent consideration	$	3,625	$	—	$	—	$	3,625
Total	$	3,625	$	—	$	—	$	3,625

Schedule of Level 3 Activity

The following table summarizes the activities for the Level 3 financial instruments:

	Noncontrolling Interest Liability		Redeemable Noncontrolling Interest		Contingent Consideration
	Three Months Ended March 31,		Three Months Ended March 31,		Three Months Ended March 31,
	2022		2021		2022		2021
	(unaudited)
	(in thousands)
Fair value — beginning of period	$	78,000	$	57,100	$	3,625	$	1,245
Increase in fair value	—		4,287		2,390		—
Net loss for the period	—		(1,987)		—		—
Fair value — end of period	$	78,000	$	59,400	$	6,015	$	1,245

Schedule of Debt Securities, Available-for-sale

The following tables summarizes the Company’s cash equivalents and marketable securities’ amortized costs, gross unrealized gains, gross unrealized losses and estimated fair values by significant investment category:

	March 31, 2022
	Amortized Cost		Gross Unrealized Gain		Gross Unrealized Loss		Estimated Fair Value
	(unaudited)
	(in thousands)
Money market fund	$	447,032	$	—	$	—	$	447,032
U.S. government debt securities	993,465		—		(16,350)		977,115
Total	$	1,440,497	$	—	$	(16,350)	$	1,424,147

	December 31, 2021
	Amortized Cost		Gross Unrealized Gain		Gross Unrealized Loss		Estimated Fair Value
	(in thousands)
Money market fund	$	357,785	$	—	$	—	$	357,785
U.S. government debt securities	1,142,172		2		(3,594)		1,138,580
Total	$	1,499,957	$	2	$	(3,594)	$	1,496,365

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Intangible Assets, Net and Goodwill (Tables)

3 Months Ended

Mar. 31, 2022

Goodwill and Intangible Assets Disclosure [Abstract]

Schedule of Finite-Lived Intangible Assets

The following table presents details of purchased intangible assets as of March 31, 2022, and December 31, 2021:

	March 31, 2022
	Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount		Remaining Weighted-Average Useful Life
	(unaudited)
	(in thousands)						(in years)
Intangible assets subject to amortization:
Acquired license	$	11,886	$	(2,746)	$	9,140	8.5
Non-compete agreements and other covenant rights	5,100		(2,113)		2,987		3.7
Total intangible assets subject to amortization	16,986		(4,859)		12,127
Intangible assets not subject to amortization:
IPR&D	1,600		—		1,600
Goodwill	3,290		—		3,290
Total purchased intangible assets	$	21,876	$	(4,859)	$	17,017

	December 31, 2021
	Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount		Remaining Weighted-Average Useful Life
	(in thousands)						(in years)
Intangible assets subject to amortization:
Acquired license	$	11,886	$	(2,473)	$	9,413	8.8
Non-compete agreements and other covenant rights	5,100		(1,906)		3,194		3.9
Total intangible assets subject to amortization	16,986		(4,379)		12,607
Intangible assets not subject to amortization:
IPR&D	1,600		—		1,600
Goodwill	3,290		—		3,290
Total purchased intangible assets	$	21,876	$	(4,379)	$	17,497

Schedule of Indefinite-Lived Intangible Assets

The following table presents details of purchased intangible assets as of March 31, 2022, and December 31, 2021:

	March 31, 2022
	Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount		Remaining Weighted-Average Useful Life
	(unaudited)
	(in thousands)						(in years)
Intangible assets subject to amortization:
Acquired license	$	11,886	$	(2,746)	$	9,140	8.5
Non-compete agreements and other covenant rights	5,100		(2,113)		2,987		3.7
Total intangible assets subject to amortization	16,986		(4,859)		12,127
Intangible assets not subject to amortization:
IPR&D	1,600		—		1,600
Goodwill	3,290		—		3,290
Total purchased intangible assets	$	21,876	$	(4,859)	$	17,017

	December 31, 2021
	Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount		Remaining Weighted-Average Useful Life
	(in thousands)						(in years)
Intangible assets subject to amortization:
Acquired license	$	11,886	$	(2,473)	$	9,413	8.8
Non-compete agreements and other covenant rights	5,100		(1,906)		3,194		3.9
Total intangible assets subject to amortization	16,986		(4,379)		12,607
Intangible assets not subject to amortization:
IPR&D	1,600		—		1,600
Goodwill	3,290		—		3,290
Total purchased intangible assets	$	21,876	$	(4,379)	$	17,497

Schedule of Finite-Lived Intangible Assets, Future Amortization Expense

The following table summarizes estimated future amortization expense of finite-lived intangible assets, net:

Year Ending December 31,
	(unaudited)
	(in thousands)
Remainder of 2022	$	1,467
2023	1,947
2024	1,953
2025	1,670
2026	1,212
2027 and thereafter	3,878
Total	$	12,127

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Debt (Tables)

3 Months Ended

Mar. 31, 2022

Debt Disclosure [Abstract]

Schedule of Long-term Debt Instrument Components

The following table sets forth the net carrying amounts of the 2027 Notes as of March 31, 2022, and December 31, 2021:

	March 31, 2022		December 31, 2021
	(unaudited)
	(in thousands)
Liability component:
Principal	$	1,150,000	$	1,150,000
Less: debt issuance costs, net of amortization	(14,537)		(15,179)
Net carrying amount	$	1,135,463	$	1,134,821

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Leases (Tables)

3 Months Ended

Mar. 31, 2022

Leases [Abstract]

Lease Information

	March 31, 2022		December 31, 2021
	(unaudited)
Weighted-average remaining lease term (in years)	9.7		10.0
Weighted-average discount rate	4.02	%	4.01	%

Schedule of Operating Lease Liability Maturities

The following table summarizes the Company's future principal contractual obligations for operating lease commitments as of March 31, 2022:

Year Ending December 31,
	(unaudited)
	(in thousands)
Remainder of 2022	$	17,030
2023	30,363
2024	32,891
2025	32,238
2026	27,753
2027 and thereafter	149,637
Total operating lease payments	$	289,912
Less: imputed interest	(47,979)
Total operating lease liabilities	$	241,933

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Common Stock (Tables)

3 Months Ended

Mar. 31, 2022

Equity [Abstract]

Schedule of Stock by Class

The Company’s common stock has been reserved for the following potential future issuances:

	March 31, 2022	December 31, 2021
	(unaudited)
Shares underlying outstanding stock options	2,509,506	2,624,974
Shares underlying unvested restricted stock units	1,506,378	1,498,553
Market-based restricted stock units	2,260,764	2,260,764
Performance-based restricted stock units	345,082	374,596
Shares available for issuance under the 2018 Incentive Award Plan	8,925,158	5,231,624
Shares available for issuance under the 2018 Employee Stock Purchase Plan	1,426,264	1,426,264
Total	16,973,152	13,416,775

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Stock-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2022

Share-based Payment Arrangement [Abstract]

Schedule of Share-based Compensation, Stock Options, Activity

A summary of the Company’s stock option activity under the 2012 Stock Plan (as amended and restated), or the 2012 Plan, and the 2018 Incentive Award Plan, or the 2018 Plan, and related information is as follows:

		Options Outstanding
	Shares Available for Grant	Shares Subject to Options Outstanding	Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (Years)	Aggregate Intrinsic Value
	(unaudited)
						(in thousands)
Balance as of January 1, 2022	5,231,624	2,624,974	$	29.17	6.5	$	193,014
2018 Plan annual increase(1)	3,689,000	—
Granted	(7,252)	7,252	62.10
Exercised	—	(105,218)	5.94
Canceled	13,268	(17,502)	74.71
Restricted stock units granted	(128,855)	—	—
Restricted stock units canceled	97,859	—	—
Performance-based restricted stock units canceled	29,514	—	—
Balance as of March 31, 2022	8,925,158	2,509,506	$	29.92	6.3	$	115,462
Vested and Exercisable as of March 31, 2022		1,957,910	$	12.56	5.6	$	109,604

(1)Effective as of January 1, 2022, an additional 3,689,000 shares of common stock became available for issuance under the 2018 Plan, as a result of the operation of an automatic annual increase provision therein.

A summary of the Joint Venture's stock option activity under the AMEA 2020 Plan and related information is as follows:

		Options Outstanding
	Shares Available for Grant	Shares Subject to Options Outstanding	Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Life (Years)	Aggregate Intrinsic Value
	(unaudited)
						(in thousands)
Balance as of January 1, 2022	340,928	3,652,219	$	0.58	8.8	$	—
Exercised	—	(582,020)	0.58
Canceled	74,999	(74,999)	0.58
Balance as of March 31, 2022	415,927	2,995,200	$	0.58	8.6	$	—
Vested and Exercisable as of March 31, 2022		1,809,430	$	0.58	8.4	$	—

Schedule of Restricted Stock Activity

A summary of the Company’s restricted stock unit activity excluding the performance-based and market-based restricted stock units under the 2012 Plan and the 2018 Plan and related information is as follows:

	Restricted Stock Units Outstanding	Weighted-Average Grant Date Fair Value
	(unaudited)
Balance as of January 1, 2022	1,498,553	$	109.72
Granted	128,855	62.10
Vested and released	(23,171)	105.58
Canceled	(97,859)	108.53
Balance as of March 31, 2022	1,506,378	$	105.78

A summary of the Company’s performance-based restricted stock unit activity under the 2018 Plan and related information is as follows:

	Performance-based Restricted Stock Units Outstanding	Weighted-Average Grant Date Fair Value
	(unaudited)
Balance as of January 1, 2022	374,596	$	116.58
Canceled	(29,514)	113.40
Balance as of March 31, 2022	345,082	$	116.86

Schedule of Performance-based Restricted Stock Units Vesting Conditions

The following table presents additional information relating to each MSU award:

Tranche	Price Goal	Number of RSUs
Tranche 1	$120 per share	565,192
Tranche 2	$150 per share	565,191
Tranche 3	$200 per share	565,191

Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan

The following table presents the effect of employee and non-employee related stock-based compensation expense including the Joint Venture:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
Cost of precision oncology testing	$	1,164	$	767
Research and development expense	5,343		4,300
Sales and marketing expense	5,525		2,880
General and administrative expense	12,767		47,122
Total stock-based compensation expense	$	24,799	$	55,069

Schedule of Share-based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions

The grant date fair value of stock options was estimated using a Black-Scholes option-pricing model with the following weighted-average assumptions including the Joint Venture:

	Three Months Ended March 31,
	2022	2021
	(unaudited)
Expected term (in years)	5.97	6.01 – 6.04
Expected volatility	63.3%	63.6% – 66.4%
Risk-free interest rate	1.9%	0.3% – 0.8%
Expected dividend yield	—%	—%

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Net Loss Per Share Attributable to Guardant Health, Inc. Common Stockholders (Tables)

3 Months Ended

Mar. 31, 2022

Earnings Per Share [Abstract]

Schedule of Earnings Per Share, Basic and Diluted

The following table sets forth the computation of the basic and diluted net loss per share attributable to Guardant Health, Inc. common stockholders:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands, except per share data)
Net loss	$	(123,228)	$	(107,358)
Adjustment of redeemable noncontrolling interest	—		(2,300)
Net loss attributable to Guardant Health, Inc. common stockholders, basic and diluted	$	(123,228)	$	(109,658)
Net loss per share attributable to Guardant Health, Inc. common stockholders, basic and diluted	$	(1.21)	$	(1.09)
Weighted-average shares used in computing net loss per share attributable to Guardant Health, Inc. common stockholders, basic and diluted	101,853		100,955

Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share

The following weighted-average common stock equivalents were excluded from the calculation of diluted net loss per share attributable to Guardant Health, Inc. common stockholders for the periods presented as they had an anti-dilutive effect:

	Three Months Ended March 31,
	2022	2021
	(unaudited)
	(in thousands)
Stock options issued and outstanding (1)	2,550	2,912
Restricted stock units	1,484	1,120
MSUs	2,261	2,646
PSUs	357	407
ESPP obligation	84	47
Common stock subject to repurchase	—	11
Convertible senior notes	8,225	8,225
Total	14,961	15,368

(1)    Excludes outstanding stock options to purchase 2,995,200 shares of the Joint Venture's Class B common stock under the AMEA 2020 Plan as of March 31, 2022.

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Segment and Geographic Information (Tables)

3 Months Ended

Mar. 31, 2022

Segment Reporting [Abstract]

Schedule of Segment Reporting Information, by Segment

The following table sets forth the Company’s revenue by geographic areas based on the customers’ locations:

	Three Months Ended March 31,
	2022		2021
	(unaudited)
	(in thousands)
United States	$	90,871	$	72,300
International (1)	5,228		6,365
Total revenue	$	96,099	$	78,665

(1)    No single country outside of the United States accounted for more than 10% of total revenue during the three months ended March 31, 2022, and 2021, respectively.

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Description of Business (Details)	May 31, 2018
Guardant Health AMEA, Inc
Subsidiary, Sale of Stock [Line Items]
Ownership interest in joint venture	50.00%

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Summary of Significant Accounting Policies - Narrative (Details) $ in Millions	1 Months Ended			3 Months Ended		12 Months Ended
	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Aug. 31, 2020 USD ($)	Mar. 31, 2022 USD ($) segment	Mar. 31, 2021 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Restricted cash	$ 0.1			$ 0.1		$ 0.1
Non-marketable equity and other investments	39.4			52.2		39.4
Impairment or adjustments of non-marketable securities				0.0
Other receivables and other assets due from a third-party			$ 8.0
Other receivables and other assets, term			6 years
Contractual receivables, installment payment	1.1	$ 1.0
Contractual receivables, credit loss				5.9
Contract asset	5.7			$ 3.1		5.7
Number of operating segments | segment				1
Impairment of goodwill				$ 0.0
Impairment of intangible assets				0.0
Post-acquisition contingent consideration expense				2.1	$ 0.0
Revenue from cash collections exceeding estimated variable consideration				2.0	5.1
Deferred revenue	$ 11.3			10.6		11.3
Deferred revenue recognized				$ 3.5	$ 5.0	$ 3.5	$ 5.0
Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Useful life (years)				6 years
Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Useful life (years)				12 years

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Summary of Significant Accounting Policies - Schedule of Concentration Risk (Details) - Credit Concentration Risk	3 Months Ended		12 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Customer A | Revenue
Concentration Risk [Line Items]
Concentration risk, percentage	30.00%	25.00%
Customer A | Accounts Receivable, Net
Concentration Risk [Line Items]
Concentration risk, percentage	10.00%		13.00%
Customer B | Accounts Receivable, Net
Concentration Risk [Line Items]
Concentration risk, percentage	11.00%		10.00%
Customer C | Accounts Receivable, Net
Concentration Risk [Line Items]
Concentration risk, percentage			13.00%
Customer D | Accounts Receivable, Net
Concentration Risk [Line Items]
Concentration risk, percentage	16.00%

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Summary of Significant Accounting Policies - Receivable and Related Credit Loss (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Accounting Policies [Abstract]
Financing receivable, gross amount, current	$ 1,100		$ 0
Financing receivable, allowance for credit losses, current	(1,100)	$ (1,100)	0
Financing receivable, net amount, current	0		0
Financing receivable, net amount, noncurrent	4,800		5,900
Financing receivable, allowance for credit losses, noncurrent	(4,800)	(5,900)	(5,900)
Financing receivable, net amount, noncurrent	0		$ 0
Financing Receivable, Allowance for Credit Loss [Roll Forward]
Beginning balance, financing receivable, allowance for credit loss, current	0	0
Reclassification, allowance for credit loss, current	1,100	1,100
Ending balance, financing receivable, allowance for credit loss, current	1,100	1,100
Beginning balance, financing receivable, allowance for credit loss, noncurrent	5,900	7,000
Reclassification, allowance for credit loss, noncurrent	(1,100)	(1,100)
Ending balance, financing receivable, allowance for credit loss, noncurrent	$ 4,800	$ 5,900

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Investment in Joint Venture (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended		3 Months Ended
		Jun. 30, 2020	May 31, 2018	Mar. 31, 2022	Dec. 31, 2021
Schedule of Equity Method Investments [Line Items]
Common stock, shares authorized (in shares)				350,000,000	350,000,000
Preferred stock, shares authorized (in shares)				10,000,000	10,000,000
Preferred stock issued (in shares)				0	0
Common stock, shares reserved for future issuance (in shares)				16,973,152	13,416,775
Common stock, shares issued (in shares)				101,895,835	101,767,446
Common stock, shares outstanding (in shares)				101,895,835	101,767,446
Preferred stock outstanding (in shares)				0	0
Assets	[1]			$ 2,129,598	$ 2,204,499
Noncontrolling interest liability				78,000	78,000
Variable Interest Entity
Schedule of Equity Method Investments [Line Items]
Assets				16,900	$ 20,400
SoftBank
Schedule of Equity Method Investments [Line Items]
Noncontrolling interest liability				$ 78,000
Threshold percentage of fair value that is no less than internal rate of return				20.00%
Guardant Health AMEA, Inc
Schedule of Equity Method Investments [Line Items]
Payments to acquire interest in joint venture			$ 9,000
Equity method investment, shares purchased (in shares)			40,000
Equity method investment, ownership percentage			50.00%
Common stock, shares authorized (in shares)		89,000,000
Guardant Health AMEA, Inc | Class A
Schedule of Equity Method Investments [Line Items]
Common stock, shares authorized (in shares)		80,000,000
Common stock, shares issued (in shares)				0	0
Common stock, shares outstanding (in shares)				0	0
Guardant Health AMEA, Inc | Class B
Schedule of Equity Method Investments [Line Items]
Common stock, shares authorized (in shares)		9,000,000
Common stock, shares issued (in shares)				1,184,428	602,408
Common stock, shares outstanding (in shares)				1,184,428	602,408
Guardant Health AMEA, Inc | Class B | AMEA 2020 Plan
Schedule of Equity Method Investments [Line Items]
Common stock, shares reserved for future issuance (in shares)		4,595,555		4,595,555
Guardant Health AMEA, Inc | Series A
Schedule of Equity Method Investments [Line Items]
Preferred stock, shares authorized (in shares)		80,000,000
Preferred stock issued (in shares)				80,000,000	80,000,000
Preferred stock dividend rate (in usd per share)		$ 0.05
Preferred stock outstanding (in shares)				80,000,000	80,000,000
Guardant Health AMEA, Inc | Series A | SoftBank
Schedule of Equity Method Investments [Line Items]
Preferred stock issued (in shares)		40,000,000
Guardant Health AMEA, Inc | Series A | Guardant Health, Inc.
Schedule of Equity Method Investments [Line Items]
Preferred stock issued (in shares)		40,000,000
Guardant Health AMEA, Inc | SoftBank
Schedule of Equity Method Investments [Line Items]
Equity method investment, shares purchased (in shares)			40,000
Equity method investment, ownership percentage			50.00%
Redeemable noncontrolling interest, redemption value			$ 41,000
Guardant Health AMEA, Inc | SoftBank | Series A
Schedule of Equity Method Investments [Line Items]
Common stock reclassified and converted into preferred stock (in shares)		1,000

[1] As of March 31, 2022 and December 31, 2021, this balance includes $16.9 million and $20.4 million of assets, respectively, that can be used only to settle obligations of the consolidated variable interest entity, or VIE and VIE’s subsidiaries, and $4.3 million and $4.3 million of liabilities of the consolidated VIE and VIE’s subsidiaries, respectively, for which their creditors do not have recourse to the general credit of the Company. See Note 3, Investment in Joint Venture.

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Condensed Consolidated Balance Sheet Components - Property, Plant and Equipment (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 212,804	$ 179,285
Less: accumulated depreciation	(61,482)	(54,824)
Property and equipment, net	151,322	124,461
Machinery and equipment
Property, Plant and Equipment [Line Items]
Property and equipment, gross	69,583	63,022
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property and equipment, gross	75,295	38,702
Computer hardware
Property, Plant and Equipment [Line Items]
Property and equipment, gross	21,787	16,685
Construction in progress
Property, Plant and Equipment [Line Items]
Property and equipment, gross	37,104	55,873
Construction in progress | Office In Palo Alto, California
Property, Plant and Equipment [Line Items]
Property and equipment, gross	16,200	45,800
Furniture and fixtures
Property, Plant and Equipment [Line Items]
Property and equipment, gross	7,596	3,683
Computer software
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 1,439	$ 1,320

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Condensed Consolidated Balance Sheet Components - Narrative (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Balance Sheet Related Disclosures [Abstract]
Depreciation and amortization expense	$ 6.7	$ 4.5

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Condensed Consolidated Balance Sheet Components - Accrued Expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Balance Sheet Related Disclosures [Abstract]
Operating lease liabilities	$ 16,556	$ 12,856
Accrued tax liabilities	4,401	4,223
Accrued professional services	8,410	6,994
Accrued clinical studies	5,151	3,332
Accrued legal expenses	6,429	4,166
Purchases of property and equipment included in accrued expenses	1,349	5,893
Others	9,555	7,821
Total accrued expenses	$ 51,851	$ 45,285

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Fair Value Measurements, Cash Equivalents and Marketable Securities - Measured on Recurring Basis (Details) - Fair Value, Measurements, Recurring - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	$ 447,032	$ 357,785
Debt securities, short-term	388,662	440,546
Debt securities, long-term	588,453	698,034
Total assets	1,424,147	1,496,365
Contingent consideration	6,015	3,625
Financial and nonfinancial liabilities, fair value disclosure	6,015	3,625
Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	447,032	357,785
Debt securities, short-term	0	0
Debt securities, long-term	0	0
Total assets	447,032	357,785
Contingent consideration	0	0
Financial and nonfinancial liabilities, fair value disclosure	0	0
Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	0	0
Debt securities, short-term	388,662	440,546
Debt securities, long-term	588,453	698,034
Total assets	977,115	1,138,580
Contingent consideration	0	0
Financial and nonfinancial liabilities, fair value disclosure	0	0
Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	0	0
Debt securities, short-term	0	0
Debt securities, long-term	0	0
Total assets	0	0
Contingent consideration	6,015	3,625
Financial and nonfinancial liabilities, fair value disclosure	6,015	3,625
U.S. government debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Debt securities, short-term	388,662	440,546
Debt securities, long-term	588,453	698,034
U.S. government debt securities | Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Debt securities, short-term	0	0
Debt securities, long-term	0	0
U.S. government debt securities | Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Debt securities, short-term	388,662	440,546
Debt securities, long-term	588,453	698,034
U.S. government debt securities | Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Debt securities, short-term	0	0
Debt securities, long-term	0	0
Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	447,032	357,785
Money market funds | Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	447,032	357,785
Money market funds | Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	0	0
Money market funds | Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	$ 0	$ 0

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Fair Value Measurements, Cash Equivalents and Marketable Securities - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Dec. 31, 2021	May 31, 2018
Minimum
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Long term maturity period (years)	1 year
Maximum
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Long term maturity period (years)	1 year 9 months 18 days
Guardant Health AMEA, Inc | SoftBank
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Redeemable noncontrolling interest, redemption value			$ 41,000
Fair Value, Measurements, Recurring
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Contingent consideration	$ 6,015	$ 3,625
Level 3 | Fair Value, Measurements, Recurring
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Contingent consideration	6,015	3,625
Contingent consideration liability, noncurrent	$ 4,500	$ 3,600

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Fair Value Measurements, Cash Equivalents and Marketable Securities - Activity In Level 3 Instruments (Details) - Fair Value, Measurements, Recurring - Level 3 - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Noncontrolling Interest Liability
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Fair value — beginning of period	$ 78,000
Increase in fair value	0
Net loss for the period	0
Fair value — end of period	78,000
Redeemable Noncontrolling Interest
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Fair value — beginning of period		$ 57,100
Increase in fair value		4,287
Net loss for the period		(1,987)
Fair value — end of period		59,400
Contingent Consideration
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Fair value — beginning of period	3,625	1,245
Increase in fair value	2,390	0
Net loss for the period	0	0
Fair value — end of period	$ 6,015	$ 1,245

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Fair Value Measurements, Cash Equivalents and Marketable Securities - Cash Equivalents and Marketable Securities (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021	Mar. 31, 2021
Debt Securities, Available-for-sale [Line Items]
Amortization cost, cash and cash equivalents	$ 573,604	$ 492,202	$ 869,372
Amortized cost, cash and cash equivalents and debt securities available-for-sale	1,440,497	1,499,957
Gross Unrealized Gain	0	2
Gross Unrealized Loss	(16,350)	(3,594)
Cash, cash equivalents and debt securities, fair value	1,424,147	1,496,365
Money market funds
Debt Securities, Available-for-sale [Line Items]
Amortization cost, cash and cash equivalents	447,032	357,785
Gross Unrealized Gain	0	0
Gross Unrealized Loss	0	0
Estimated fair value, cash and cash equivalents	447,032	357,785
U.S. government debt securities
Debt Securities, Available-for-sale [Line Items]
Amortized cost, debt securities, available-for-sale	993,465	1,142,172
Gross Unrealized Gain	0	2
Gross Unrealized Loss	(16,350)	(3,594)
Estimated fair value, debt securities	$ 977,115	$ 1,138,580

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Intangible Assets, Net and Goodwill - Schedule of Intangible Assets by Class (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2022	Dec. 31, 2021
Finite-Lived Intangible Assets [Line Items]
Intangible assets subject to amortization, gross carrying amount	$ 16,986	$ 16,986
Intangible assets subject to amortization, accumulated amortization	(4,859)	(4,379)
Intangible assets subject to amortization, net	12,127	12,607
Goodwill	3,290	3,290
Gross Carrying Amount	21,876	21,876
Net Carrying Amount	17,017	17,497
IPR&D
Finite-Lived Intangible Assets [Line Items]
IPR&D	1,600	1,600
Acquired license
Finite-Lived Intangible Assets [Line Items]
Intangible assets subject to amortization, gross carrying amount	11,886	11,886
Intangible assets subject to amortization, accumulated amortization	(2,746)	(2,473)
Intangible assets subject to amortization, net	$ 9,140	$ 9,413
Remaining Weighted-Average Useful Life	8 years 6 months	8 years 9 months 18 days
Non-compete agreements and other covenant rights
Finite-Lived Intangible Assets [Line Items]
Intangible assets subject to amortization, gross carrying amount	$ 5,100	$ 5,100
Intangible assets subject to amortization, accumulated amortization	(2,113)	(1,906)
Intangible assets subject to amortization, net	$ 2,987	$ 3,194
Remaining Weighted-Average Useful Life	3 years 8 months 12 days	3 years 10 months 24 days

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Intangible Assets, Net and Goodwill - Narrative (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Goodwill and Intangible Assets Disclosure [Abstract]
Amortization of intangible assets	$ 0.5	$ 0.5

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Intangible Assets, Net and Goodwill - Schedule of Future Amortization (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Goodwill and Intangible Assets Disclosure [Abstract]
Remainder of 2022	$ 1,467
2023	1,947
2024	1,953
2025	1,670
2026	1,212
2027 and thereafter	3,878
Intangible assets subject to amortization, net	$ 12,127	$ 12,607

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Debt - Narrative (Details)	1 Months Ended	3 Months Ended
	Nov. 30, 2020 USD ($) d $ / shares	Mar. 31, 2022 USD ($)	Mar. 31, 2021 USD ($)	Dec. 31, 2021 USD ($)	Nov. 16, 2020 $ / shares
Debt Instrument [Line Items]
Amortization of debt issuance costs | $		$ 642,000	$ 641,000
Strike price (in dollars per share) | $ / shares					$ 182.60
Share price, premium					75.00%
Common stock share price (in dollars per share) | $ / shares					$ 104.34
Purchase of convertible senior note hedges | $	$ 90,000,000
Senior Notes Due 2027 | Convertible Debt
Debt Instrument [Line Items]
Principal amount | $	$ 1,150,000,000	1,150,000,000		$ 1,150,000,000
Stated interest rate	0.00%
Maximum special interest rate percentage	0.50%
Conversion ratio	0.0071523
Conversion price (in dollars per share) | $ / shares	$ 139.82
Estimated fair value | $		900,000,000		$ 1,200,000,000
Amortization of debt issuance costs | $		$ 600,000	$ 600,000
Effective interest rate of the liability component		0.20%	0.20%
Senior Notes Due 2027 | Convertible Debt | Valuation, Market Approach | Measurement Input, Quoted Price
Debt Instrument [Line Items]
Debt, measurement input denominator | $		100
Senior Notes Due 2027 | Convertible Debt | Conversion Period One
Debt Instrument [Line Items]
Threshold percentage of common stock price trigger	130.00%
Threshold of common stock trading days | d	20
Threshold of consecutive common stock trading days | d	30
Senior Notes Due 2027 | Convertible Debt | Conversion Period Two
Debt Instrument [Line Items]
Threshold of common stock trading days | d	5
Threshold of consecutive common stock trading days | d	10
Minimum percentage of common stock price trigger	98.00%
Senior Notes Due 2027 | Convertible Debt | Conversion Period Three
Debt Instrument [Line Items]
Threshold percentage of common stock price trigger	130.00%
Threshold of common stock trading days | d	20
Threshold of consecutive common stock trading days | d	30

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Debt - Components of Convertible Senior Notes (Details) - Convertible Debt - Senior Notes Due 2027 - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021	Nov. 30, 2020
Debt Instrument [Line Items]
Principal	$ 1,150,000	$ 1,150,000	$ 1,150,000
Less: debt issuance costs, net of amortization	(14,537)	(15,179)
Net carrying amount	$ 1,135,463	$ 1,134,821

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Leases - Narrative (Details) $ in Millions	1 Months Ended	3 Months Ended
	Feb. 28, 2022 USD ($)	Mar. 31, 2022 USD ($)	Mar. 31, 2021 USD ($)	Jul. 31, 2020 agreement
Lessee, Lease, Description [Line Items]
Operating lease expense		$ 6.9	$ 3.9
Additional Office Space
Lessee, Lease, Description [Line Items]
Number of lease agreements | agreement				2
San Diego Lease
Lessee, Lease, Description [Line Items]
Lease term				8 years
Palo Alto Lease
Lessee, Lease, Description [Line Items]
Lease term				12 years
Option for lease renewal term				10 years
Lease payment	$ 0.9
Minimum
Lessee, Lease, Description [Line Items]
Lease term		1 year
Maximum
Lessee, Lease, Description [Line Items]
Lease term		12 years

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Leases - Lease Information (Details)	Mar. 31, 2022	Dec. 31, 2021
Leases [Abstract]
Weighted-average remaining lease term (in years)	9 years 8 months 12 days	10 years
Weighted-average discount rate	4.02%	4.01%

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Leases - Schedule of Operating Liability Maturities (Details) $ in Thousands	Mar. 31, 2022 USD ($)
Leases [Abstract]
Remainder of 2022	$ 17,030
2023	30,363
2024	32,891
2025	32,238
2026	27,753
2027 and thereafter	149,637
Total operating lease payments	289,912
Less: imputed interest	(47,979)
Total operating lease liabilities	$ 241,933

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Commitments and Contingencies (Details)	1 Months Ended
	Oct. 31, 2021 patent
TwinStrand Biosciences And University Of Washington vs. Guardant Health, Inc.
Other Commitments [Line Items]
Gain contingency, patents allegedly infringed upon, number	4

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Common Stock (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2022	Dec. 31, 2021
Class of Stock [Line Items]
Dividends on common stock	$ 0	$ 0
Common stock, shares reserved for future issuance (in shares)	16,973,152	13,416,775
Shares underlying outstanding stock options
Class of Stock [Line Items]
Common stock, shares reserved for future issuance (in shares)	2,509,506	2,624,974
Shares underlying unvested restricted stock units
Class of Stock [Line Items]
Common stock, shares reserved for future issuance (in shares)	1,506,378	1,498,553
Market-based restricted stock units
Class of Stock [Line Items]
Common stock, shares reserved for future issuance (in shares)	2,260,764	2,260,764
Performance-based restricted stock units
Class of Stock [Line Items]
Common stock, shares reserved for future issuance (in shares)	345,082	374,596
Shares available for issuance under the 2018 Incentive Award Plan
Class of Stock [Line Items]
Common stock, shares reserved for future issuance (in shares)	8,925,158	5,231,624
Shares available for issuance under the 2018 Employee Stock Purchase Plan
Class of Stock [Line Items]
Common stock, shares reserved for future issuance (in shares)	1,426,264	1,426,264

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Stock-Based Compensation - Stock Option Activity (Details) - USD ($) $ / shares in Units, $ in Thousands		3 Months Ended	12 Months Ended
	Jan. 01, 2022	Mar. 31, 2022	Dec. 31, 2021
Shares Available for Grant
Beginning number of shares, available for grant (in shares)	5,231,624	5,231,624
2018 Plan annual increase (in shares)	3,689,000	3,689,000
Ending number of shares, available for grant (in shares)		8,925,158	5,231,624
Shares Subject to Options Outstanding
Beginning number of shares, outstanding (in shares)	2,624,974	2,624,974
Granted (in shares)		7,252
Exercised (in shares)		(105,218)
Canceled (in shares)		(17,502)
Ending number of shares, outstanding (in shares)		2,509,506	2,624,974
Options vested and exercisable, number of options (in shares)		1,957,910
Weighted-Average Exercise Price
Beginning balance of options outstanding (in usd per share)	$ 29.17	$ 29.17
Granted (in usd per share)		62.10
Exercised (in usd per share)		5.94
Canceled (in usd per share)		74.71
Ending balance of options outstanding (in usd per share)		29.92	$ 29.17
Options vested and exercisable, weighted average exercise price per share (in usd per share)		$ 12.56
Weighted-Average Remaining Contractual Life and Aggregate Intrinsic Value
Options outstanding, weighted average remaining contractual term (in years)		6 years 3 months 18 days	6 years 6 months
Options outstanding, aggregate intrinsic value		$ 115,462	$ 193,014
Options vested and exercisable, weighted average remaining contractual term (in years)		5 years 7 months 6 days
Options vested and exercisable, aggregate intrinsic value		$ 109,604
2018 plan annual increase (in shares)	3,689,000	3,689,000
Equity Option
Shares Available for Grant
Granted (in shares)		(7,252)
Canceled (in shares)		13,268
Restricted Stock Units
Shares Available for Grant
Granted (in shares)		(128,855)
Canceled (in shares)		97,859
Performance-based restricted stock units
Shares Available for Grant
Canceled (in shares)		29,514

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Stock-Based Compensation - Narrative (Details) $ / shares in Units, $ in Thousands		1 Months Ended		3 Months Ended
	Jan. 01, 2020 shares	Nov. 30, 2020 USD ($)	May 31, 2020 tranche $ / shares shares	Mar. 31, 2022 USD ($) $ / shares shares	Mar. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2021 $ / shares shares	Jun. 30, 2020 shares	Sep. 30, 2018 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted average grant date fair value, grants in period (in usd per share) | $ / shares				$ 36.32	$ 101.21
Stock based compensation not recognized, options | $				$ 27,900
Stock based compensation not recognized, period for recognition (years)				2 years 10 months 24 days
Stock-based compensation | $				$ 24,799	$ 55,069
Common stock, shares reserved for future issuance (in shares)				16,973,152		13,416,775
AMEA 2020 Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Granted (in shares)				0
Class B | AMEA 2020 Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted average grant date fair value, grants in period (in usd per share) | $ / shares					$ 0.33
Stock based compensation not recognized, options | $				$ 300
Stock based compensation not recognized, period for recognition (years)				2 years 4 months 24 days
Guardant Health AMEA, Inc | Class B | AMEA 2020 Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock, shares reserved for future issuance (in shares)				4,595,555			4,595,555
Guardant Health AMEA, Inc | Class B | AMEA 2020 Plan | Tranche One
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Market-based stock unit vesting period				4 years
Option term, expiration period				10 years
Guardant Health AMEA, Inc | Class B | AMEA 2020 Plan | Tranche Two
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Option term, expiration period				5 years
Threshold percentage for individual's combined voting power triggering five year option term				10.00%
Purchase price of common stock (as a percent of the fair value of common stock)				110.00%
Stock options issued and outstanding
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercises in period, intrinsic value | $				$ 7,300	$ 38,300
Common stock, shares reserved for future issuance (in shares)				2,509,506		2,624,974
Expected dividend yield				0.00%	0.00%
Shares underlying unvested restricted stock units
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation not recognized, period for recognition (years)				3 years
Stock based compensation not recognized, other than options | $				$ 130,100
Weighted average grant date fair value of MSU (in usd per share) | $ / shares				$ 62.10
Unvested balance (in shares)				1,506,378		1,498,553
Weighted average grant date fair value (in usd per share) | $ / shares				$ 105.78		$ 109.72
Granted (in shares)				128,855
Vested (in shares)				(23,171)
Canceled (in shares)				(97,859)
Common stock, shares reserved for future issuance (in shares)				1,506,378		1,498,553
Performance-based restricted stock units
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation not recognized, period for recognition (years)				2 years 10 months 24 days
Stock based compensation not recognized, other than options | $				$ 3,500
Additional service period requirement		6 months
Weighted-average derivative service period		4 years
Stock-based compensation | $		$ 0		$ 300	$ 300
Unvested balance (in shares)				345,082		374,596
Weighted average grant date fair value (in usd per share) | $ / shares				$ 116.86		$ 116.58
Canceled (in shares)				(29,514)
Common stock, shares reserved for future issuance (in shares)				345,082		374,596
Performance-based restricted stock units | Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Market-based stock unit vesting period		4 years
Performance-based restricted stock units | Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Market-based stock unit vesting period		4 years 6 months
MSUs
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation not recognized, period for recognition (years)				2 months 12 days
Stock based compensation not recognized, other than options | $				$ 7,600
Market-based stock unit vesting period			7 years	7 years
Stock-based compensation | $				$ 8,500	43,900
Market-based restricted stock share price goal			30 days
Weighted average grant date fair value of MSU (in usd per share) | $ / shares				$ 67.00
Unvested balance (in shares)				2,260,764		2,260,764
Weighted average grant date fair value (in usd per share) | $ / shares				$ 65.20
Granted (in shares)				0
Vested (in shares)				0
Canceled (in shares)				0
Common stock, shares reserved for future issuance (in shares)				2,260,764		2,260,764
MSUs | Tranche 1 - $120 per share
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Price goal (in dollars per share) | $ / shares			$ 120	$ 120
MSUs | Chief Executive Officer
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total market-based restricted stock units approved and granted (in shares)			1,695,574
Number of tranches | tranche			3
MSUs | Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted-average derivative service period				9 months 29 days
Market-based stock units holding period during vesting			6 months
MSUs | Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted-average derivative service period				2 years 25 days
Market-based stock units holding period during vesting			12 months
Shares available for issuance under the 2018 Employee Stock Purchase Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation not recognized, period for recognition (years)				1 month 6 days
Stock based compensation not recognized, other than options | $				$ 500
Stock-based compensation | $				$ 1,000	$ 800
Purchase price of common stock (as a percent of the fair value of common stock)				85.00%
Common stock, shares reserved for future issuance (in shares)				1,426,264		1,426,264
Shares authorized (in shares)	942,614
Maximum employee subscription rate, ESPP				10.00%
Purchase period				6 months
Common stock issued under employee stock purchase plan (in shares)				0	0
Shares available for issuance under the 2018 Employee Stock Purchase Plan | 2018 Employee Stock Purchase Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares approved (in share)								922,250

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Stock-Based Compensation - Restricted Stock Activity (Details)	3 Months Ended
	Mar. 31, 2022 $ / shares shares
Shares underlying unvested restricted stock units
Outstanding
Beginning unvested balance (in shares) | shares	1,498,553
Granted (in shares) | shares	128,855
Vested and released (in shares) | shares	(23,171)
Canceled (in shares) | shares	(97,859)
Ending unvested balance (in shares) | shares	1,506,378
Weighted-Average Grant Date Fair Value
Beginning balance of options outstanding (in usd per share) | $ / shares	$ 109.72
Granted (in usd per share) | $ / shares	62.10
Vested and released (in usd per share) | $ / shares	105.58
Canceled (in usd per share) | $ / shares	108.53
Ending balance of options outstanding (in usd per share) | $ / shares	$ 105.78
Performance-based restricted stock units
Outstanding
Beginning unvested balance (in shares) | shares	374,596
Canceled (in shares) | shares	(29,514)
Ending unvested balance (in shares) | shares	345,082
Weighted-Average Grant Date Fair Value
Beginning balance of options outstanding (in usd per share) | $ / shares	$ 116.58
Canceled (in usd per share) | $ / shares	113.40
Ending balance of options outstanding (in usd per share) | $ / shares	$ 116.86

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Stock-Based Compensation - Market-based Restricted Stock Units (Details) - MSUs - $ / shares	1 Months Ended	3 Months Ended
	May 31, 2020	Mar. 31, 2022
Tranche 1 - $120 per share
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Price goal (in dollars per share)	$ 120	$ 120
Number of MSUs (in shares)		565,192
Tranche 2 - $150 per share
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Price goal (in dollars per share)		$ 150
Number of MSUs (in shares)		565,191
Tranche 3 - $200 per share
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Price goal (in dollars per share)		$ 200
Number of MSUs (in shares)		565,191

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Stock-Based Compensation - AMEA 2020 Equity Incentive Plan (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2022	Dec. 31, 2021
Shares Available for Grant
Beginning number of shares, available for grant (in shares)	5,231,624
Ending number of shares, available for grant (in shares)	8,925,158	5,231,624
Shares Subject to Options Outstanding
Beginning number of shares, outstanding (in shares)	2,624,974
Exercised (in shares)	(105,218)
Canceled (in shares)	(17,502)
Ending number of shares, outstanding (in shares)	2,509,506	2,624,974
Options vested and exercisable, number of options (in shares)	1,957,910
Weighted-Average Exercise Price
Beginning balance of options outstanding (in usd per share)	$ 29.17
Exercised (in usd per share)	5.94
Canceled (in usd per share)	74.71
Ending balance of options outstanding (in usd per share)	29.92	$ 29.17
Options vested and exercisable, weighted average exercise price per share (in usd per share)	$ 12.56
Weighted-Average Remaining Contractual Life and Aggregate Intrinsic Value
Options outstanding, weighted average remaining contractual term (in years)	6 years 3 months 18 days	6 years 6 months
Options vested and exercisable, weighted average remaining contractual term (in years)	5 years 7 months 6 days
Options outstanding, aggregate intrinsic value	$ 115,462	$ 193,014
Options vested and exercisable, aggregate intrinsic value	$ 109,604
AMEA 2020 Plan | Class B
Shares Available for Grant
Beginning number of shares, available for grant (in shares)	340,928
Canceled (in shares)	74,999
Ending number of shares, available for grant (in shares)	415,927	340,928
Shares Subject to Options Outstanding
Beginning number of shares, outstanding (in shares)	3,652,219
Exercised (in shares)	(582,020)
Canceled (in shares)	(74,999)
Ending number of shares, outstanding (in shares)	2,995,200	3,652,219
Options vested and exercisable, number of options (in shares)	1,809,430
Weighted-Average Exercise Price
Beginning balance of options outstanding (in usd per share)	$ 0.58
Exercised (in usd per share)	0.58
Canceled (in usd per share)	0.58
Ending balance of options outstanding (in usd per share)	0.58	$ 0.58
Options vested and exercisable, weighted average exercise price per share (in usd per share)	$ 0.58
Weighted-Average Remaining Contractual Life and Aggregate Intrinsic Value
Options outstanding, weighted average remaining contractual term (in years)	8 years 7 months 6 days	8 years 9 months 18 days
Options vested and exercisable, weighted average remaining contractual term (in years)	8 years 4 months 24 days
Options outstanding, aggregate intrinsic value	$ 0	$ 0
Options vested and exercisable, aggregate intrinsic value	$ 0

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Stock-Based Compensation - Stock Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	$ 24,799	$ 55,069
Cost of precision oncology testing
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	1,164	767
Research and development expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	5,343	4,300
Sales and marketing expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	5,525	2,880
General and administrative expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	$ 12,767	$ 47,122

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Stock-Based Compensation - Valuation of Stock Options (Details) - Stock options issued and outstanding	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected dividend yield	0.00%	0.00%
Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected term (in years)	5 years 11 months 19 days	6 years 3 days
Expected volatility	63.30%	63.60%
Risk-free interest rate	1.90%	0.30%
Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected term (in years)		6 years 14 days
Expected volatility		66.40%
Risk-free interest rate		0.80%

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Net Loss Per Share Attributable to Guardant Health, Inc. Common Stockholders - Schedule of Net Loss Per Share (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Earnings Per Share [Abstract]
Net loss	$ (123,228)	$ (107,358)
Adjustment of redeemable noncontrolling interest	0	(2,300)
Net loss attributable to Guardant Health, Inc. common stockholders	(123,228)	(109,658)
Net loss attributable to Guardant Health, Inc. common stockholders	$ (123,228)	$ (109,658)
Net loss per share attributable to Guardant Health, Inc. common stockholders, basic (in usd per share)	$ (1.21)	$ (1.09)
Net loss per share attributable to Guardant Health, Inc. common stockholders, diluted (in usd per share)	$ (1.21)	$ (1.09)
Weighted-average shares used in computing net loss per share attributable to Guardant Health, Inc. common stockholders, basic (in shares)	101,853	100,955
Weighted-average shares used in computing net loss per share attributable to Guardant Health, Inc. common stockholders, diluted (in shares)	101,853	100,955

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Net Loss Per Share Attributable to Guardant Health, Inc. Common Stockholders - Schedule of Antidilutive Securities (Details) - shares	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	14,961,000	15,368,000
Stock options outstanding (in shares)	2,509,506		2,624,974
AMEA 2020 Plan | Class B
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Stock options outstanding (in shares)	2,995,200		3,652,219
Stock options issued and outstanding
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	2,550,000	2,912,000
Restricted stock units
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	1,484,000	1,120,000
MSUs
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	2,261,000	2,646,000
PSUs
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	357,000	407,000
ESPP obligation
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	84,000	47,000
Common stock subject to repurchase
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	0	11,000
Convertible senior notes
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	8,225,000	8,225,000

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Segment and Geographic Information (Details) $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2022 USD ($) segment	Mar. 31, 2021 USD ($)	Dec. 31, 2021
Segment Reporting Information [Line Items]
Number of operating segments | segment	1
Total revenue	$ 96,099	$ 78,665
Assets | Geographic Concentration Risk | Net Assets, Geographic Area
Segment Reporting Information [Line Items]
Concentration risk, percentage	98.00%		98.00%
United States
Segment Reporting Information [Line Items]
Total revenue	$ 90,871	72,300
International
Segment Reporting Information [Line Items]
Total revenue	$ 5,228	$ 6,365

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Label	Element	Value
Accounting Standards Update [Extensible Enumeration]	us-gaap_AccountingStandardsUpdateExtensibleList	Accounting Standards Update 2020-06 [Member]