Exhibit 107

Ex – Filing Fees

Calculation of Filing Fee Tables

Form 424(b)(5)

(Form Type)

GUARDANT HEALTH, INC.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered and Carry Forward Securities

	Security   Type	Security Class Title(1)	Fee   Calculation   or Carry   Forward   Rule	Amount Registered	Proposed   Maximum   Offering   Price Per   Unit	Maximum   Aggregate   Offering   Price	Fee Rate	Amount of   Registration   Fee	Carry   Forward   Form   Type	Carry   Forward   File   Number	Carry   Forward   Initial   effective   date	Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward
Newly Registered Securities
Fees to Be Paid	Guardant Health, Inc.
	Equity	Common Stock, $0.00001 par value per share	Rule   457(r)(1)	14,375,000   (2)	$28.00	$402,500,000	0.00011020	$44,355.50
Fees   Previously   Paid	N/A	—	—	—	—	—		—
Carry Forward Securities
Carry Forward Securities	N/A	—	—	—	—	—		—	—	—	—	—
	Total Offering Amounts					$402,500,000		$44,355.50
	Total Fees Previously Paid							—
	Total Fee Offsets							—
	Net Fee Due							$44,355.50

(1) The filing fee is calculated and being paid pursuant to Rule 457(r) under the Securities Act of 1933, as amended, or the Securities Act, based on the proposed maximum aggregate offering price, and relates to the registrant’s Registration Statement on Form S-3 (File No. 333-272121) in accordance with Rules 456(b) and 457(r) under the Securities Act.

(2) Includes share of common stock that the underwriters have an option to purchase.