Exhibit 107

Calculation of Filing Fee Tables

Form S-8

(Form Type)

Guardant Health, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered Securities

Security Type

Security Class Title

Fee Calculation Rule

Amount Registered (1)

Proposed Maximum Offering Price Per Share (2)

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Fees to Be Paid

Equity

Common Stock, $0.0001 par value per share

457(c) and 457(h)

3,689,000(3)

$61.26

$225,988,140

$92.70 per $1,000,000

$20,949.10

Fees Previously Paid

Total Offering Amounts

$

225,988,140

$

20,949.10

Total Fees Previously Paid

–

Total Fee Offsets

–

Net Fee Due

$

20,949.10

(1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the “Securities Act”), this registration statement shall also cover any additional shares of the common stock, $0.00001 par value per share (“Common Stock”) of Guardant Health, Inc. (the “Registrant”), that become issuable under the 2018 Incentive Award Plan (the “2018 Plan”) by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration that increases the number of the Registrant’s outstanding shares of Common Stock.

(2) Estimated in accordance with Rule 457(c) and 457(h) solely for the purpose of calculating the registration fee. The maximum price per share and the maximum aggregate offering price are based upon the average of the high and low prices of the Registrant’s Common Stock as reported on the Nasdaq Global Market on February 23, 2022, which date is within five business days prior to filing this Registration Statement.

(3) Represents additional shares of the Registrant’s Common Stock that became available for issuance on January 1, 2022 under the 2018 Plan, by operation of an automatic annual increase provision therein.