CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional paid-in capital	Accumulated other comprehensive loss	Accumulated deficit
Balance at beginning of period (shares) at Dec. 31, 2021		55,356,904
Balance at beginning of period at Dec. 31, 2021	$ 1,397,038	$ 55	$ 3,099,937	$ 9,068	$ (1,712,022)
Increase (Decrease) in Stockholders' Equity
Net loss	(538,392)				(538,392)
Issuance of common stock, net of issuance costs (shares)		1,880,097
Issuance of common stock under ATM, net of issuance costs	155,011	$ 2	155,009
Issuance of common stock from ESPP (shares)		29,891
Issuance of common stock from ESPP	995		995
Share-based compensation expense	124,581		124,581
Issuance of common stock under equity incentive plans (shares)		301,877
Issuance of common stock under equity incentive plans	5,018	$ 1	5,017
Unrealized gain (loss) on investments	(5,712)			(5,712)
Foreign currency translation adjustment	(9,485)			(9,485)
Balance at end of period (shares) at Sep. 30, 2022		57,568,769
Balance at end of period at Sep. 30, 2022	1,129,054	$ 58	3,385,539	(6,129)	(2,250,414)
Balance at beginning of period (shares) at Jun. 30, 2022		55,592,631
Balance at beginning of period at Jun. 30, 2022	1,112,004	$ 56	3,185,444	3,357	(2,076,853)
Increase (Decrease) in Stockholders' Equity
Net loss	(173,561)				(173,561)
Issuance of common stock, net of issuance costs (shares)		1,880,097
Issuance of common stock under ATM, net of issuance costs	155,011	$ 2	155,009
Issuance of common stock from ESPP (shares)		0
Issuance of common stock from ESPP			0
Share-based compensation expense	42,992		42,992
Issuance of common stock under equity incentive plans (shares)		96,041
Issuance of common stock under equity incentive plans	2,094	$ 0	2,094
Unrealized gain (loss) on investments	(1)			(1)
Foreign currency translation adjustment	(9,485)			(9,485)
Balance at end of period (shares) at Sep. 30, 2022		57,568,769
Balance at end of period at Sep. 30, 2022	$ 1,129,054	$ 58	3,385,539	(6,129)	(2,250,414)
Balance at beginning of period (shares) at Dec. 31, 2022	57,854,559	57,854,559
Balance at beginning of period at Dec. 31, 2022	$ 996,516	$ 58	3,453,066	(3,719)	(2,452,889)
Increase (Decrease) in Stockholders' Equity
Net loss	(523,403)				(523,403)
Issuance of common stock, net of issuance costs (shares)		11,288,336
Issuance of common stock under ATM, net of issuance costs	332,515	$ 11	332,504
Issuance of common stock from ESPP (shares)		105,352
Issuance of common stock from ESPP	3,328		3,328
Share-based compensation expense	130,913		130,913
Issuance of common stock under equity incentive plans (shares)		863,062
Issuance of common stock under equity incentive plans	4,427	$ 1	4,426
Unrealized gain (loss) on investments	2,175			2,175
Foreign currency translation adjustment	$ (6)			(6)
Balance at end of period (shares) at Sep. 30, 2023	70,111,309	70,111,309
Balance at end of period at Sep. 30, 2023	$ 946,465	$ 70	3,924,237	(1,550)	(2,976,292)
Balance at beginning of period (shares) at Jun. 30, 2023		58,339,232
Balance at beginning of period at Jun. 30, 2023	728,951	$ 58	3,544,996	(1,715)	(2,814,388)
Increase (Decrease) in Stockholders' Equity
Net loss	(161,904)				(161,904)
Issuance of common stock, net of issuance costs (shares)		11,288,336
Issuance of common stock under ATM, net of issuance costs	332,515	$ 11	332,504
Issuance of common stock from ESPP (shares)		0
Issuance of common stock from ESPP			0
Share-based compensation expense	44,553		44,553
Issuance of common stock under equity incentive plans (shares)		483,741
Issuance of common stock under equity incentive plans	2,185	$ 1	2,184
Unrealized gain (loss) on investments	106			106
Foreign currency translation adjustment	$ 59			59
Balance at end of period (shares) at Sep. 30, 2023	70,111,309	70,111,309
Balance at end of period at Sep. 30, 2023	$ 946,465	$ 70	$ 3,924,237	$ (1,550)	$ (2,976,292)