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Shareholders' Equity (Tables)
9 Months Ended
Sep. 30, 2023
Share-Based Payment Arrangement [Abstract]  
Schedule of Employee Service Share-based Compensation Allocation
Total share-based compensation expense included in the condensed consolidated statements of operations and comprehensive loss consisted of the following (in thousands):

Three Months Ended September 30,
Nine Months Ended September 30,
2023202220232022
Research and development expense$19,480 $28,276 $62,518 $77,343 
Selling, general and administrative expense25,073 14,716 68,395 47,238 
$44,553 $42,992 $130,913 $124,581