CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional paid-in capital	Accumulated other comprehensive loss	Accumulated deficit
Balance at beginning of period (shares) at Dec. 31, 2021		55,356,904
Balance at beginning of period at Dec. 31, 2021	$ 1,397,038	$ 55	$ 3,099,937	$ 9,068	$ (1,712,022)
Increase (Decrease) in Stockholders' Equity
Net loss	(364,831)				(364,831)
Issuance of common stock from ESPP (shares)		29,891
Issuance of common stock from employee stock purchase plan	995		995
Share-based compensation expense	81,589		81,589
Issuance of common stock under equity incentive plans (shares)		205,836
Issuance of common stock under equity incentive plans	2,924	$ 1	2,923
Unrealized gain (loss) on investments	(5,711)			(5,711)
Foreign currency translation adjustment	0
Balance at end of period (shares) at Jun. 30, 2022		55,592,631
Balance at end of period at Jun. 30, 2022	1,112,004	$ 56	3,185,444	3,357	(2,076,853)
Balance at beginning of period (shares) at Mar. 31, 2022		55,511,476
Balance at beginning of period at Mar. 31, 2022	1,249,282	$ 56	3,145,368	4,266	(1,900,408)
Increase (Decrease) in Stockholders' Equity
Net loss	(176,445)				(176,445)
Issuance of common stock from ESPP (shares)		29,891
Issuance of common stock from employee stock purchase plan	995		995
Share-based compensation expense	38,684		38,684
Issuance of common stock under equity incentive plans (shares)		51,264
Issuance of common stock under equity incentive plans	397	$ 0	397
Unrealized gain (loss) on investments	(909)			(909)
Foreign currency translation adjustment	0
Balance at end of period (shares) at Jun. 30, 2022		55,592,631
Balance at end of period at Jun. 30, 2022	$ 1,112,004	$ 56	3,185,444	3,357	(2,076,853)
Balance at beginning of period (shares) at Dec. 31, 2022	57,854,559	57,854,559
Balance at beginning of period at Dec. 31, 2022	$ 996,516	$ 58	3,453,066	(3,719)	(2,452,889)
Increase (Decrease) in Stockholders' Equity
Net loss	(361,499)				(361,499)
Issuance of common stock from ESPP (shares)		105,352
Issuance of common stock from employee stock purchase plan	3,328		3,328
Share-based compensation expense	86,360		86,360
Issuance of common stock under equity incentive plans (shares)		379,321
Issuance of common stock under equity incentive plans	2,242	$ 0	2,242
Unrealized gain (loss) on investments	2,069			2,069
Foreign currency translation adjustment	$ (65)			(65)
Balance at end of period (shares) at Jun. 30, 2023	58,339,232	58,339,232
Balance at end of period at Jun. 30, 2023	$ 728,951	$ 58	3,544,996	(1,715)	(2,814,388)
Balance at beginning of period (shares) at Mar. 31, 2023		58,148,416
Balance at beginning of period at Mar. 31, 2023	862,630	$ 58	3,501,754	(1,707)	(2,637,475)
Increase (Decrease) in Stockholders' Equity
Net loss	(176,913)				(176,913)
Issuance of common stock from ESPP (shares)		105,352
Issuance of common stock from employee stock purchase plan	3,328		3,328
Share-based compensation expense	39,399		39,399
Issuance of common stock under equity incentive plans (shares)		85,464
Issuance of common stock under equity incentive plans	515		515
Unrealized gain (loss) on investments	26			26
Foreign currency translation adjustment	$ (34)			(34)
Balance at end of period (shares) at Jun. 30, 2023	58,339,232	58,339,232
Balance at end of period at Jun. 30, 2023	$ 728,951	$ 58	$ 3,544,996	$ (1,715)	$ (2,814,388)