CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Total revenue	$ 13,690	$ 5,362	$ 20,857	$ 6,071
Revenue
Total revenue	13,690	5,362	20,857	6,071
Operating expenses
Cost of product revenue	1,025	0	1,583	0
Cost of product revenue - intangible asset amortization	258	0	517	0
Research and development	124,187	128,339	250,870	259,315
Selling, general and administrative	75,490	54,228	148,980	108,179
Total operating expenses	200,960	182,567	401,950	367,494
Loss from operations	(187,270)	(177,205)	(381,093)	(361,423)
Other income (expense), net	10,357	760	19,594	(3,408)
Net loss	(176,913)	(176,445)	(361,499)	(364,831)
Foreign currency translation adjustment	(34)	0	(65)	0
Unrealized gain (loss) on available-for-sale investments	26	(909)	2,069	(5,711)
Comprehensive loss	$ (176,921)	$ (177,354)	$ (359,495)	$ (370,542)
Basic net loss per share (USD per share)	$ (3.04)	$ (3.18)	$ (6.22)	$ (6.57)
Diluted net loss per share (USD per share)	$ (3.04)	$ (3.18)	$ (6.22)	$ (6.57)
Weighted average common shares outstanding, basic (shares)	58,232,084	55,552,438	58,131,954	55,510,649
Weighted average common shares outstanding, diluted (shares)	58,232,084	55,552,438	58,131,954	55,510,649
Product Revenue
Total revenue	$ 13,365	$ 0	$ 19,656	$ 0
Revenue
Total revenue	13,365	0	19,656	0
License and Collaboration Revenue
Total revenue	325	5,362	1,201	6,071
Revenue
Total revenue	$ 325	$ 5,362	$ 1,201	$ 6,071