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Warrants
 6 Months Ended
Jun. 30, 2023
Equity [Abstract]  
Warrants
At the Market Facility

On July 2, 2020, the Company entered into a sales agreement pursuant to which the Company may, from time to time, sell shares of the Company’s common stock, par value $0.001 per share, having an aggregate offering price of up to $200.0 million. On July 2, 2021, the Company entered into an amended and restated sales agreement pursuant to which the Company may, from time to time, sell shares of the Company’s common stock, par value $0.001 per share, having an aggregate offering price of up to $500.0 million. During the three and six months ended June 30, 2023 and 2022, no shares of common stock were issued and sold under this sales agreement. As of June 30, 2023, the Company has issued and sold an aggregate of 1,880,097 shares of common stock pursuant to this sales agreement generating net proceeds of $155.0 million.

Share-based Compensation

Total share-based compensation expense included in the condensed consolidated statements of operations and comprehensive loss consisted of the following (in thousands):

Three Months Ended June 30,
Six Months Ended June 30,
2023202220232022
Research and development expense$18,399 $22,807 $43,038 $49,067 
Selling, general and administrative expense21,000 15,877 43,322 32,522 
$39,399 $38,684 $86,360 $81,589 
    
During the three and six months ended June 30, 2023, 85,464 and 379,321 shares of common stock were issued under the Company’s equity incentive plans, generating net proceeds of $0.5 million and $2.2 million, respectively. During the three and six months ended June 30, 2022, 51,264 and 205,836 shares of common stock were issued under the Company’s equity incentive plans, generating net proceeds of $0.4 million and $2.9 million, respectively.
Issuances Under Employee Stock Purchase Plan

On May 11, 2023, an amendment to the Company’s 2013 Employee Stock Purchase Plan (“ESPP”) was approved by the Company’s shareholders, to increase the aggregate number of shares of common stock reserved for issuance under the ESPP by 750,000 shares. During the three and six months ended June 30, 2023, 105,352 shares of common stock were issued under the Company’s ESPP, generating net proceeds of $3.3 million. During the three and six months ended June 30, 2022, 29,891 shares of common stock were issued under the Company’s ESPP, generating net proceeds of $1.0 million.
Warrants

As of June 30, 2023, the following warrants for common stock were issued and outstanding:

Issue DateExpiration DateExercise Price Number of Warrants Outstanding
January 11, 2017None$0.001 3,578,036 
November 20, 2017None$0.001 3,669,360 
June 11, 2018None$0.001 358,415 
7,605,811 
No warrants were exercised during the three and six months ended June 30, 2023 or 2022.