CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional paid-in capital	Accumulated other comprehensive loss	Accumulated deficit
Balance at beginning of period (shares) at Dec. 31, 2021		55,356,904
Balance at beginning of period at Dec. 31, 2021	$ 1,397,038	$ 55	$ 3,099,937	$ 9,068	$ (1,712,022)
Increase (Decrease) in Stockholders' Equity
Net loss	(188,386)				(188,386)
Share-based compensation expense	42,905		42,905
Issuance of common stock under equity incentive plans (shares)		154,572
Issuance of common stock under equity incentive plans	2,527	$ 1	2,526
Unrealized gain (loss) on investments	(4,802)			(4,802)
Foreign currency translation adjustment	0
Balance at end of period (shares) at Mar. 31, 2022		55,511,476
Balance at end of period at Mar. 31, 2022	$ 1,249,282	$ 56	3,145,368	4,266	(1,900,408)
Balance at beginning of period (shares) at Dec. 31, 2022	57,854,559	57,854,559
Balance at beginning of period at Dec. 31, 2022	$ 996,516	$ 58	3,453,066	(3,719)	(2,452,889)
Increase (Decrease) in Stockholders' Equity
Net loss	(184,586)				(184,586)
Share-based compensation expense	46,961		46,961
Issuance of common stock under equity incentive plans (shares)		293,857
Issuance of common stock under equity incentive plans	1,727	$ 0	1,727
Unrealized gain (loss) on investments	2,043			2,043
Foreign currency translation adjustment	$ (31)			(31)
Balance at end of period (shares) at Mar. 31, 2023	58,148,416	58,148,416
Balance at end of period at Mar. 31, 2023	$ 862,630	$ 58	$ 3,501,754	$ (1,707)	$ (2,637,475)