Accrued Liabilities and Other Liabilities - Summary (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Accrued liabilities:
Accrued clinical expense	$ 45,495	$ 37,604
Accrued manufacturing expense	5,697	6,605
Accrued development expense	5,234	20,107
Accrued compensation and benefits	27,204	40,208
Accrued commercial expense	4,669	3,941
Accrued royalty expense	503	0
Accrued adjustments to product revenue	1,052	152
Other accrued expenses	4,524	4,126
Lease liability (current)	7,902	7,844
Total accrued liabilities	102,280	120,587
Other liabilities	$ 3,304	$ 3,022