CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Current assets
Cash and cash equivalents	$ 241,925	$ 235,260
Short-term investments	660,369	848,577
Accounts receivable, net	6,227	865
Inventory	3,849	3,020
Other current assets	26,980	21,239
Total current assets	939,350	1,108,961
Property and equipment, net	17,185	17,540
Intangible asset, net	14,655	14,914
Long-term investment	3,353	3,465
Right-of-use asset	35,783	36,122
Other long-term assets	23,435	21,645
Total assets	1,033,761	1,202,647
Current liabilities
Accounts payable	22,320	38,861
Accrued liabilities	102,280	120,587
Total current liabilities	124,600	159,448
Lease liability	43,227	43,661
Other liabilities	3,304	3,022
Total liabilities	171,131	206,131
Commitments and contingencies (see Note 11)
Shareholders' equity
Preferred stock, $0.001 par value, 10,000,000 shares authorized; none issued and outstanding at both March 31, 2023 and December 31, 2022	0	0
Common stock, $0.001 par value; 100,000,000 authorized; 58,148,416 and 57,854,559 issued and outstanding at March 31, 2023 and December 31, 2022, respectively	58	58
Additional paid-in capital	3,501,754	3,453,066
Accumulated other comprehensive loss	(1,707)	(3,719)
Accumulated deficit	(2,637,475)	(2,452,889)
Total shareholders' equity	862,630	996,516
Total liabilities and shareholders' equity	$ 1,033,761	$ 1,202,647