Income Taxes - Effective Income Tax Rate Reconciliation (Details) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Effective Income Tax Rate Reconciliation, Amount [Abstract]
Net loss before tax	$ (740,359)	$ (578,485)	$ (357,937)
Statutory combined U.S. federal and state tax rate (as a percent)	21.00%	21.00%	21.00%
Tax computed at federal statutory rate	$ (155,475)	$ (121,482)	$ (75,167)
State income taxes, net of federal benefit	(2,305)	(4,657)	(13,490)
Effect of change in valuation allowance	198,064	150,487	110,985
Non-deductible share-based compensation	6,754	4,783	2,724
Tax deductions for share-based compensation	3,876	(17,243)	(17,991)
Tax credits	(73,383)	(30,289)	(15,672)
Dissolution of Canadian entity	24,761	0	0
Foreign withholding taxes	508	3,299	0
Change in tax rate	(11,224)	2,972	0
Unrecognized tax benefits	6,965	7,573	3,857
Return to provision and other true-ups	(3,871)	115	25
Non-deductible officers’ compensation	5,969	8,318	4,697
Other differences	(131)	(577)	32
Income tax expense	$ 508	$ 3,299	$ 0

Effective Income Tax Rate Reconciliation, Combined Federal and State Statutory Income Tax Rate, Percent

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Effective Income Tax Rate Reconciliation, Non-Deductible Officers' Compensation, Amount

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Amount of income (loss) from continuing operations, including income (loss) from equity method investments, before deduction of income tax expense (benefit), and income (loss) attributable to noncontrolling interest.

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