Income Taxes - Narrative (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Income Tax [Line Items]
Income tax expense	$ 508,000	$ 3,299,000	$ 0
Amount of increase in valuation allowance	(198,600,000)
Accrual for interest or penalties on tax matters	0	0	0
Foreign Tax Authority
Income Tax [Line Items]
Income tax expense	500,000
US Federal
Income Tax [Line Items]
Income tax expense		$ 3,300,000	$ 0
Tax credit carryforward	1,100,000,000
US Federal | Research Tax Credit Carryforward
Income Tax [Line Items]
Tax credit carryforward	69,700,000
US Federal | Orphan Drug Tax Credit Carryforward
Income Tax [Line Items]
Tax credit carryforward	49,000,000
US State
Income Tax [Line Items]
Tax credit carryforward	1,600,000
US State | Research Tax Credit Carryforward
Income Tax [Line Items]
Tax credit carryforward	30,000,000
CALIFORNIA
Income Tax [Line Items]
Tax credit carryforward	$ 271,800,000