CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional paid-in capital	Accumulated other comprehensive income (loss)	Accumulated deficit
Balance at beginning of period (shares) at Dec. 31, 2019		39,517,329
Balance at beginning of period at Dec. 31, 2019	$ 382,295	$ 40	$ 1,144,667	$ 9,889	$ (772,301)
Increase (Decrease) in Stockholders' Equity
Net loss	(357,937)				(357,937)
Issuance of common stock and warrants, net of issuance costs (shares)		8,124,168
Issuance of common stock, net of issuance costs	1,203,617	$ 8	1,203,609
Share-based compensation expense	85,847		85,847
Issuance of common stock from ESPP (shares)		14,436
Issuance of common stock from ESPP	1,206		1,206
Issuance of common stock under equity incentive plans (shares)		1,319,901
Issuance of common stock under equity incentive plans	$ 45,891	$ 1	45,890
Net exercise of warrants (shares)	1,400,000	1,463,235
Net exercise of warrants	$ 0	$ 1	(1)
Unrealized gain (loss) on investments	(130)			(130)
Foreign currency translation adjustment	0
Balance at end of period (shares) at Dec. 31, 2020		50,439,069
Balance at end of period at Dec. 31, 2020	1,360,789	$ 50	2,481,218	9,759	(1,130,238)
Increase (Decrease) in Stockholders' Equity
Net loss	(581,784)				(581,784)
Issuance of common stock and warrants, net of issuance costs (shares)		3,448,275
Issuance of common stock, net of issuance costs	474,697	$ 3	474,694
Share-based compensation expense	113,502		113,502
Issuance of common stock from ESPP (shares)		20,672
Issuance of common stock from ESPP	2,567		2,567
Issuance of common stock under equity incentive plans (shares)		825,074
Issuance of common stock under equity incentive plans	$ 27,958	$ 1	27,957
Net exercise of warrants (shares)	623,814	623,814
Net exercise of warrants	$ 0	$ 1	(1)
Unrealized gain (loss) on investments	(691)			(691)
Foreign currency translation adjustment	$ 0
Balance at end of period (shares) at Dec. 31, 2021	55,356,904	55,356,904
Balance at end of period at Dec. 31, 2021	$ 1,397,038	$ 55	3,099,937	9,068	(1,712,022)
Increase (Decrease) in Stockholders' Equity
Net loss	(740,867)				(740,867)
Issuance of common stock and warrants, net of issuance costs (shares)		1,880,097
Issuance of common stock, net of issuance costs	155,011	$ 2	155,009
Share-based compensation expense	186,188		186,188
Issuance of common stock from ESPP (shares)		59,732
Issuance of common stock from ESPP	2,008		2,008
Issuance of common stock under equity incentive plans (shares)		557,826
Issuance of common stock under equity incentive plans	9,925	$ 1	9,924
Unrealized gain (loss) on investments	(3,224)			(3,224)
Foreign currency translation adjustment	$ (9,563)			(9,563)
Balance at end of period (shares) at Dec. 31, 2022	57,854,559	57,854,559
Balance at end of period at Dec. 31, 2022	$ 996,516	$ 58	$ 3,453,066	$ (3,719)	$ (2,452,889)