Accrued Liabilities and Other Liabilities - Summary (Details) - USD ($)	Dec. 31, 2022	Dec. 31, 2021
Accrued Liabilities and Other Liabilities [Abstract]
Accrued clinical expense	$ 37,604,000	$ 29,038,000
Accrued manufacturing expense	6,605,000	34,153,000
Accrued development expense	20,107,000	10,910,000
Accrued compensation and benefits	40,208,000	25,845,000
Accrued commercial expense	3,941,000	3,650,000
Accrued adjustments to product revenue	152,000	0
Lease liability (current)	7,844,000	1,341,000
Other accrued expenses	4,126,000	3,558,000
Total accounts payable and accrued liabilities	120,587,000	108,495,000
Other liabilities	$ 3,022,000	$ 2,179,000