CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Total revenue	$ 12,436	$ 72,092	$ 13,398
Revenue
Total revenue	12,436	72,092	13,398
Operating expenses
Cost of product revenue	600	0	0
Research and development	531,627	508,594	299,349
Selling, general and administrative	239,798	136,679	83,412
Total operating expenses	772,025	645,273	382,761
Loss from operations	(759,589)	(573,181)	(369,363)
Other income (expense), net	19,230	(5,304)	11,426
Net loss before tax	(740,359)	(578,485)	(357,937)
Income tax expense	508	3,299	0
Net loss	(740,867)	(581,784)	(357,937)
Foreign currency translation adjustment	(9,563)	0	0
Unrealized loss on available-for-sale investments	3,224	691	130
Comprehensive loss	$ (753,654)	$ (582,475)	$ (358,067)
Basic net loss per share (USD per share)	$ (13.18)	$ (11.21)	$ (7.96)
Diluted net loss per share (USD per share)	$ (13.18)	$ (11.21)	$ (7.96)
Weighted average common shares outstanding, basic (shares)	56,232,249	51,882,538	44,987,555
Weighted average common shares outstanding, diluted (shares)	56,232,249	51,882,538	44,987,555
Product revenue, net
Total revenue	$ 713	$ 0	$ 0
Revenue
Total revenue	713	0	0
License and collaboration revenues
Total revenue	11,723	72,092	13,398
Revenue
Total revenue	$ 11,723	$ 72,092	$ 13,398