CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Operating activities:
Net loss	$ (538,392)	$ (382,164)
Non-cash adjustments reconciling net loss to operating cash flows
Change in fair value on long-term investment	6,336	4,376
Depreciation of property and equipment	2,038	1,219
Amortization of premium and accretion of discounts on investments	(151)	3,503
Share-based compensation expense	124,581	79,624
Loss on disposal of fixed assets	294	0
Foreign currency adjustments	(9,485)	0
Changes in operating assets and liabilities:
Other current assets	(8,149)	(3,939)
Other long-term assets	(2,009)	(9,218)
Right-of-use asset	1,220	1,718
Lease liability	4,039	3,927
Accounts payable, accrued liabilities and other liabilities	(22,092)	50,139
Cash flows used in operating activities	(441,770)	(250,815)
Investing activities:
Purchases of short-term investments	(719,371)	(1,059,140)
Sales and maturities of short-term investments	889,918	648,223
Purchases of property and equipment	(4,041)	(7,146)
Cash flows provided by (used in) investing activities	166,506	(418,063)
Financing activities:
Proceeds from Issuance of Common Stock	155,011	0
Proceeds from issuance of common stock under equity incentive plans	5,018	24,726
Proceeds from issuances under employee stock purchase plan	995	1,214
Cash flows provided by financing activities	161,024	25,940
Decrease in cash, cash equivalents and restricted cash	(114,240)	(642,938)
Cash, cash equivalents and restricted cash, beginning of period	413,703	886,182
Cash, cash equivalents and restricted cash, end of period	299,463	243,244
Reconciliation of cash, cash equivalents and restricted cash, end of period:
Cash and cash equivalents	298,843	242,624
Restricted cash included in other long-term assets	620	620
Total cash, cash equivalents and restricted cash	299,463	243,244
Supplemental disclosures of non-cash investing activities:
Accrued capital expenditures	$ 367	$ 279