CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional paid-in capital	Accumulated other comprehensive (loss) income	Accumulated deficit
Balance at beginning of period (shares) at Dec. 31, 2020		50,439,069
Balance at beginning of period at Dec. 31, 2020	$ 1,360,789	$ 50	$ 2,481,218	$ 9,759	$ (1,130,238)
Increase (Decrease) in Stockholders' Equity
Net loss	(382,164)				(382,164)
Share-based compensation expense	79,624		79,624
Issuance of common stock from ESPP (shares)		9,029
Issuance of common stock from ESPP	1,214		1,214
Issuance of common stock under equity incentive plans (shares)		695,171
Issuance of common stock under equity incentive plans	$ 24,726	$ 1	24,725
Net exercise of warrants (shares)	623,814	623,814
Net exercise of warrants	$ 0	$ 1	(1)
Unrealized gain (loss) on investments	(164)			(164)
Foreign currency translation adjustment	0
Balance at end of period (shares) at Sep. 30, 2021		51,767,083
Balance at end of period at Sep. 30, 2021	1,084,025	$ 52	2,586,780	9,595	(1,512,402)
Balance at beginning of period (shares) at Jun. 30, 2021		51,608,944
Balance at beginning of period at Jun. 30, 2021	1,128,920	$ 52	2,551,615	9,601	(1,432,348)
Increase (Decrease) in Stockholders' Equity
Net loss	(80,054)				(80,054)
Share-based compensation expense	26,933		26,933
Issuance of common stock under equity incentive plans (shares)		158,139
Issuance of common stock under equity incentive plans	8,232	$ 0	8,232
Unrealized gain (loss) on investments	(6)			(6)
Foreign currency translation adjustment	0
Balance at end of period (shares) at Sep. 30, 2021		51,767,083
Balance at end of period at Sep. 30, 2021	$ 1,084,025	$ 52	2,586,780	9,595	(1,512,402)
Balance at beginning of period (shares) at Dec. 31, 2021	55,356,904	55,356,904
Balance at beginning of period at Dec. 31, 2021	$ 1,397,038	$ 55	3,099,937	9,068	(1,712,022)
Increase (Decrease) in Stockholders' Equity
Net loss	(538,392)				(538,392)
Issuance of common stock, net of issuance costs (shares)		1,880,097
Issuance of common stock under ATM, net of issuance costs	155,011	$ 2	155,009
Share-based compensation expense	124,581		124,581
Issuance of common stock from ESPP (shares)		29,891
Issuance of common stock from ESPP	995		995
Issuance of common stock under equity incentive plans (shares)		301,877
Issuance of common stock under equity incentive plans	5,018	$ 1	5,017
Unrealized gain (loss) on investments	(5,712)			(5,712)
Foreign currency translation adjustment	$ (9,485)			(9,485)
Balance at end of period (shares) at Sep. 30, 2022	57,568,769	57,568,769
Balance at end of period at Sep. 30, 2022	$ 1,129,054	$ 58	3,385,539	(6,129)	(2,250,414)
Balance at beginning of period (shares) at Jun. 30, 2022		55,592,631
Balance at beginning of period at Jun. 30, 2022	1,112,004	$ 56	3,185,444	3,357	(2,076,853)
Increase (Decrease) in Stockholders' Equity
Net loss	(173,561)				(173,561)
Issuance of common stock, net of issuance costs (shares)		1,880,097
Issuance of common stock under ATM, net of issuance costs	155,011	$ 2	155,009
Share-based compensation expense	42,992		42,992
Issuance of common stock under equity incentive plans (shares)		96,041
Issuance of common stock under equity incentive plans	2,094		2,094
Unrealized gain (loss) on investments	(1)			(1)
Foreign currency translation adjustment	$ (9,485)			(9,485)
Balance at end of period (shares) at Sep. 30, 2022	57,568,769	57,568,769
Balance at end of period at Sep. 30, 2022	$ 1,129,054	$ 58	$ 3,385,539	$ (6,129)	$ (2,250,414)