Accrued Liabilities and Other Liabilities - Summary (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Accrued liabilities:
Accrued clinical expense	$ 48,003	$ 29,038
Accrued manufacturing expense	10,763	34,153
Accrued development expense	6,531	10,910
Accrued compensation and benefits	28,563	25,845
Other accrued expenses	6,508	7,208
Lease liability (current)	7,166	1,341
Total accrued liabilities	107,534	108,495
Other liabilities	$ 2,951	$ 2,179