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Shareholders' Equity (Tables)
 9 Months Ended
Sep. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of Employee Service Share-based Compensation Allocation
Total share-based compensation expense by statement of operations and comprehensive loss classification is presented below (in thousands):
Three Months Ended September 30,
Nine Months Ended September 30,
2022202120222021
Research and development expense$28,276 $15,701 $77,343 $46,704 
General and administrative expense14,716 11,232 47,238 32,920 
$42,992 $26,933 $124,581 $79,624