CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Current assets
Cash and cash equivalents	$ 298,843	$ 413,083
Short-term investments	902,149	1,078,257
Other current assets	24,792	16,643
Total current assets	1,225,784	1,507,983
Property and equipment, net	17,900	15,824
Long-term investment	1,882	8,218
Right-of-use asset	36,460	37,680
Other long-term assets	21,058	19,049
Total assets	1,303,084	1,588,754
Current liabilities
Accounts payable	19,452	35,163
Accrued liabilities	107,534	108,495
Total current liabilities	126,986	143,658
Lease liability	44,093	45,879
Other liabilities	2,951	2,179
Total liabilities	174,030	191,716
Commitments and contingencies (see Note 9)
Shareholders' equity
Preferred stock, $0.001 par value, 10,000,000 shares authorized; none issued and outstanding at both September 30, 2022 and December 31, 2021	0	0
Common stock, $0.001 par value; 100,000,000 authorized; 57,568,769 and 55,356,904 issued and outstanding at September 30, 2022 and December 31, 2021, respectively	58	55
Additional paid-in capital	3,385,539	3,099,937
Accumulated other comprehensive (loss) income	(6,129)	9,068
Accumulated deficit	(2,250,414)	(1,712,022)
Total shareholders' equity	1,129,054	1,397,038
Total liabilities and shareholders' equity	$ 1,303,084	$ 1,588,754