CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional paid-in capital	Accumulated other comprehensive income	Accumulated deficit
Balance at beginning of period (shares) at Dec. 31, 2020		50,439,069
Balance at beginning of period at Dec. 31, 2020	$ 1,360,789	$ 50	$ 2,481,218	$ 9,759	$ (1,130,238)
Increase (Decrease) in Stockholders' Equity
Net loss	(302,110)				(302,110)
Share-based compensation expense	52,691		52,691
Issuance of common stock from ESPP (shares)		9,029
Issuance of common stock from ESPP	1,214		1,214
Issuance of common stock under equity incentive plans (shares)		537,032
Issuance of common stock under equity incentive plans	$ 16,494	$ 1	16,493
Net exercise of warrants (shares)	623,814	623,814
Net exercise of warrants	$ 0	$ 1	(1)
Unrealized gain (loss) on investments	(158)			(158)
Balance at end of period (shares) at Jun. 30, 2021		51,608,944
Balance at end of period at Jun. 30, 2021	1,128,920	$ 52	2,551,615	9,601	(1,432,348)
Balance at beginning of period (shares) at Mar. 31, 2021		51,375,786
Balance at beginning of period at Mar. 31, 2021	1,259,413	$ 51	2,515,824	9,456	(1,265,918)
Increase (Decrease) in Stockholders' Equity
Net loss	(166,430)				(166,430)
Share-based compensation expense	27,969		27,969
Issuance of common stock from ESPP (shares)		9,029
Issuance of common stock from ESPP	1,214		1,214
Issuance of common stock under equity incentive plans (shares)		224,129
Issuance of common stock under equity incentive plans	6,609	$ 1	6,608
Unrealized gain (loss) on investments	145			145
Balance at end of period (shares) at Jun. 30, 2021		51,608,944
Balance at end of period at Jun. 30, 2021	$ 1,128,920	$ 52	2,551,615	9,601	(1,432,348)
Balance at beginning of period (shares) at Dec. 31, 2021	55,356,904	55,356,904
Balance at beginning of period at Dec. 31, 2021	$ 1,397,038	$ 55	3,099,937	9,068	(1,712,022)
Increase (Decrease) in Stockholders' Equity
Net loss	(364,831)				(364,831)
Share-based compensation expense	81,589		81,589
Issuance of common stock from ESPP (shares)		29,891
Issuance of common stock from ESPP	995		995
Issuance of common stock under equity incentive plans (shares)		205,836
Issuance of common stock under equity incentive plans	2,924	$ 1	2,923
Unrealized gain (loss) on investments	$ (5,711)			(5,711)
Balance at end of period (shares) at Jun. 30, 2022	55,592,631	55,592,631
Balance at end of period at Jun. 30, 2022	$ 1,112,004	$ 56	3,185,444	3,357	(2,076,853)
Balance at beginning of period (shares) at Mar. 31, 2022		55,511,476
Balance at beginning of period at Mar. 31, 2022	1,249,282	$ 56	3,145,368	4,266	(1,900,408)
Increase (Decrease) in Stockholders' Equity
Net loss	(176,445)				(176,445)
Share-based compensation expense	38,684		38,684
Issuance of common stock from ESPP (shares)		29,891
Issuance of common stock from ESPP	995		995
Issuance of common stock under equity incentive plans (shares)		51,264
Issuance of common stock under equity incentive plans	397		397
Unrealized gain (loss) on investments	$ (909)			(909)
Balance at end of period (shares) at Jun. 30, 2022	55,592,631	55,592,631
Balance at end of period at Jun. 30, 2022	$ 1,112,004	$ 56	$ 3,185,444	$ 3,357	$ (2,076,853)