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Shareholders' Equity (Tables)
 6 Months Ended
Jun. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of Employee Service Share-based Compensation Allocation
Total share-based compensation expense by statement of operations and comprehensive loss classification is presented below (in thousands):
Three Months Ended June 30,
Six Months Ended June 30,
2022202120222021
Research and development expense$22,807 $16,469 $49,067 $31,003 
General and administrative expense15,877 11,500 32,522 21,688 
$38,684 $27,969 $81,589 $52,691