CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Current assets
Cash and cash equivalents	$ 265,602	$ 413,083
Short-term investments	915,726	1,078,257
Other current assets	21,598	16,643
Total current assets	1,202,926	1,507,983
Property and equipment, net	17,163	15,824
Long-term investment	2,635	8,218
Right-of-use asset	36,823	37,680
Other long-term assets	20,243	19,049
Total assets	1,279,790	1,588,754
Current liabilities
Accounts payable	24,269	35,163
Accrued liabilities	94,878	108,495
Total current liabilities	119,147	143,658
Lease liability	45,823	45,879
Other liabilities	2,816	2,179
Total liabilities	167,786	191,716
Commitments and contingencies (see Note 9)
Shareholders' equity
Preferred stock, $0.001 par value, 10,000,000 shares authorized; none issued and outstanding at both June 30, 2022 and December 31, 2021	0	0
Common stock, $0.001 par value; 100,000,000 authorized; 55,592,631 and 55,356,904 issued and outstanding at June 30, 2022 and December 31, 2021, respectively	56	55
Additional paid-in capital	3,185,444	3,099,937
Accumulated other comprehensive income	3,357	9,068
Accumulated deficit	(2,076,853)	(1,712,022)
Total shareholders' equity	1,112,004	1,397,038
Total liabilities and shareholders' equity	$ 1,279,790	$ 1,588,754