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Investments
3 Months Ended
Mar. 31, 2022
Investments, Debt and Equity Securities [Abstract]  
Investments
The following tables summarize the Company’s short-term investments (in thousands):
As of March 31, 2022
MaturityAmortized costGross unrealized gainsGross unrealized lossesEstimated fair value
Corporate debt securities
2 years or less
$191,505 $$(1,416)$190,091 
Commercial paper
1 year or less
548,407 — (1,623)546,784 
U.S. Agency bonds
1 years or less
21,000 — (6)20,994 
U.S. Treasury bills
2 years or less
266,120 — (2,211)263,909 
$1,027,032 $$(5,256)$1,021,778 

As of December 31, 2021
Maturity Amortized costGross unrealized gainsGross unrealized lossesEstimated fair value
Corporate debt securities
2 years or less
$236,170 $36 $(248)$235,958 
Commercial paper
1 year or less
621,947 127 (95)621,979 
U.S. Agency bonds
1 years or less
58,092 — — 58,092 
U.S. Treasury bills
2 years or less
162,500 — (272)162,228 
$1,078,709 $163 $(615)$1,078,257 

The Company has classified all of its short-term investments as available-for-sale as the sale of such securities may be required prior to maturity to implement management strategies, and accordingly, these investments are carried at fair value. As of March 31, 2022 and December 31, 2021, the unrealized losses for available-for-sale investments were non-credit related, and the Company does not intend to sell the investments before recovery of their amortized cost basis, which may be at the time of maturity. As of March 31, 2022 and December 31, 2021, no allowance for credit losses was recorded. During the three months ended March 31, 2022 and 2021, the Company did not recognize any impairment losses related to investments.

The long-term investment balance of $3.1 million and $8.2 million as of March 31, 2022 and December 31, 2021, respectively, is comprised of 588,235 shares of ORIC Pharmaceuticals, Inc. (“ORIC”) common stock. As of March 31, 2022 the investment is carried at fair value which is based on the closing price of ORIC’s common stock on the last trading day of the reporting period; unrealized gains and losses are recorded in other expense, net on the Company’s condensed consolidated statements of operations and comprehensive loss. As of December 31, 2021, the fair value was based on the last trading day of the reporting period and was adjusted for a discount for lack of marketability due to an eighteen-month lock-up period which expired during the first quarter of 2022. The Company currently does not intend to sell ORIC shares within 12 months from March 31, 2022. See Note 4 - Fair Value Measurements.