CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional paid-in capital	Accumulated other comprehensive income	Accumulated deficit
Balance at beginning of period (shares) at Dec. 31, 2020		50,439,069
Balance at beginning of period at Dec. 31, 2020	$ 1,360,789	$ 50	$ 2,481,218	$ 9,759	$ (1,130,238)
Increase (Decrease) in Stockholders' Equity
Net loss	(135,680)				(135,680)
Share-based compensation expense	24,722		24,722
Issuance of common stock under equity incentive plans (shares)		312,903
Issuance of common stock under equity incentive plans	$ 9,885	$ 0	9,885
Net exercise of warrants (shares)	623,814	623,814
Net exercise of warrants		$ 1	(1)
Unrealized loss on investments	$ (303)			(303)
Balance at end of period (shares) at Mar. 31, 2021		51,375,786
Balance at end of period at Mar. 31, 2021	$ 1,259,413	$ 51	2,515,824	9,456	(1,265,918)
Balance at beginning of period (shares) at Dec. 31, 2021	55,356,904	55,356,904
Balance at beginning of period at Dec. 31, 2021	$ 1,397,038	$ 55	3,099,937	9,068	(1,712,022)
Increase (Decrease) in Stockholders' Equity
Net loss	(188,386)				(188,386)
Share-based compensation expense	42,905		42,905
Issuance of common stock under equity incentive plans (shares)		154,572
Issuance of common stock under equity incentive plans	2,527	$ 1	2,526
Unrealized loss on investments	$ (4,802)			(4,802)
Balance at end of period (shares) at Mar. 31, 2022	55,511,476	55,511,476
Balance at end of period at Mar. 31, 2022	$ 1,249,282	$ 56	$ 3,145,368	$ 4,266	$ (1,900,408)