Accrued Liabilities and Other Liabilities - Summary (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Accrued clinical expense	$ 30,411	$ 29,038
Accrued manufacturing expense	33,318	34,153
Accrued development expense	7,282	10,910
Accrued compensation and benefits	15,559	25,845
Other accrued expenses	9,063	8,549
Accrued liabilities, current	$ 95,633	$ 108,495