CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Current assets
Cash and cash equivalents	$ 304,696	$ 413,083
Short-term investments	1,021,778	1,078,257
Other current assets	16,643	16,643
Total current assets	1,343,117	1,507,983
Property and equipment, net	17,177	15,824
Long-term investment	3,141	8,218
Right-of-use asset	37,229	37,700
Other long-term assets	20,635	19,049
Total assets	1,421,299	1,588,754
Current liabilities
Accounts payable	27,938	35,163
Accrued liabilities	95,633	108,495
Total current liabilities	123,571	143,658
Lease liability	45,829
Other liabilities	2,617	2,179
Total liabilities	172,017	191,716
Commitments and contingencies (see Note 9)
Shareholders' equity
Preferred stock, $0.001 par value, 10,000,000 shares authorized; none issued and outstanding at both March 31, 2022 and December 31, 2021	0	0
Common stock, $0.001 par value; 100,000,000 authorized; 55,511,476 and 55,356,904 issued and outstanding at March 31, 2022 and December 31, 2021, respectively	56	55
Additional paid-in capital	3,145,368	3,099,937
Accumulated other comprehensive income	4,266	9,068
Accumulated deficit	(1,900,408)	(1,712,022)
Total shareholders' equity	1,249,282	1,397,038
Total liabilities and shareholders' equity	$ 1,421,299	$ 1,588,754