CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenue
Total revenue	$ 72,092	$ 13,398	$ 3,335
Expenses
Research and development	508,594	299,349	182,866
General and administrative	136,679	83,412	42,573
Total operating expenses	645,273	382,761	225,439
Loss from operations	(573,181)	(369,363)	(222,104)
Other (expense) income, net	(5,304)	11,426	8,848
Net loss before tax	(578,485)	(357,937)	(213,256)
Income tax expense	3,299	0	0
Net loss	(581,784)	(357,937)	(213,256)
Unrealized (loss) gain on available-for-sale investments	691	130	(410)
Comprehensive loss	$ (582,475)	$ (358,067)	$ (212,846)
Basic net loss per share (USD per share)	$ (11.21)	$ (7.96)	$ (5.69)
Diluted net loss per share (USD per share)	$ (11.21)	$ (7.96)	$ (5.69)
Weighted average common shares outstanding, basic (shares)	51,882,538	44,987,555	37,467,505
Weighted average common shares outstanding, diluted (shares)	51,882,538	44,987,555	37,467,505