Accrued Liabilities and Other Liabilities - Summary (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Accrued Liabilities and Other Liabilities [Abstract]
Accrued clinical expense	$ 29,038	$ 19,221
Accrued manufacturing expense	34,153	13,019
Accrued development expense	10,910	5,439
Accrued compensation and benefits	25,845	13,964
Other accrued expenses	8,549	1,712
Total accounts payable and accrued liabilities	$ 108,495	$ 53,355