CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets
Cash and cash equivalents	$ 413,083	$ 885,562
Short-term investments	1,078,257	504,544
Other current assets	16,643	13,537
Total current assets	1,507,983	1,403,643
Property and equipment, net	15,824	7,809
Long-term investment	8,218	15,629
Right-of-use asset		39,900
Other long-term assets	19,049	9,157
Total assets	1,588,754	1,476,128
Current liabilities
Accounts payable	35,163	18,117
Accrued liabilities	108,495	53,355
Total current liabilities	143,658	71,472
Lease liability	45,879
Other liabilities	2,179	1,962
Total liabilities	191,716	115,339
Commitments and contingencies (see Note 14)
Shareholders’ equity
Preferred stock, $0.001 par value, 10,000,000 shares authorized; none issued and outstanding at both December 31, 2021 and December 31, 2020	0	0
Common stock, $0.001 par value; 100,000,000 authorized; 55,356,904 and 50,439,069 issued and outstanding at December 31, 2021 and December 31, 2020, respectively	55	50
Additional paid-in capital	3,099,937	2,481,218
Accumulated other comprehensive income	9,068	9,759
Accumulated deficit	(1,712,022)	(1,130,238)
Total shareholders’ equity	1,397,038	1,360,789
Total liabilities and shareholders’ equity	$ 1,588,754	$ 1,476,128