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Shareholders' Equity - Narrative (Details) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended
Oct. 31, 2020
Jan. 31, 2020
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Jul. 02, 2021
Dec. 31, 2020
Jul. 02, 2020
Class of Stock [Line Items]                  
Stock issued in transaction (shares) 4,585,706 3,538,462              
Sale price of common stock (USD per share) $ 202.00 $ 97.50              
Proceeds from sale of stock $ 879,600,000 $ 324,000,000              
Common stock, par value (USD per share)     $ 0.001   $ 0.001     $ 0.001  
Stock issued pursuant to stock option exercises (shares)     158,139 272,158 695,171 1,092,468      
Proceeds from stock options exercised     $ 8,200,000 $ 12,400,000 $ 24,700,000 $ 36,300,000      
At the Market Facility                  
Class of Stock [Line Items]                  
Common stock, par value (USD per share)                 $ 0.001
Aggregate offering price                 $ 200,000,000
Amended and Restated At the Market Facility                  
Class of Stock [Line Items]                  
Common stock, par value (USD per share)             $ 0.001    
Aggregate offering price             $ 500,000,000