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Shareholders' Equity (Tables)
 6 Months Ended
Jun. 30, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of Employee Service Share-based Compensation Allocation
Total share-based compensation expense by statement of operations and comprehensive loss classification is presented below (in thousands):
Three Months Ended June 30,Six Months Ended June 30,
2021202020212020
Research and development expense$16,469 $11,457 $31,003 $23,305 
General and administrative expense11,500 9,330 21,688 19,049 
$27,969 $20,787 $52,691 $42,354