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Collaboration Agreements - Narrative (Details) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Jan. 07, 2018
Oct. 31, 2014
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2020
Jun. 30, 2019
Dec. 31, 2018
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Expenses related to collaboration agreement     $ 65,083,000 $ 38,324,000 $ 136,791,000 $ 72,564,000  
BeiGene Agreement              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Up-front fee received $ 10,000,000.0            
Revenue from performance obligation expected to be earned $ 123,000,000.0            
Termination of contract, period after first commercial sale of product 10 years            
Period required for notice of termination of contract 60 days            
Revenue from performance obligations satisfied during reporting period         29,000    
BeiGene Agreement | Licenses of Intellectual Property              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue from performance obligation earned     0 0 0 0 $ 9,500,000
BeiGene Agreement | Manufacturing Supply Services              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue from performance obligation earned           1,600,000 $ 500,000
Payments received in advance     0 (600,000) (300,000) (1,800,000)  
Revenue from performance obligations satisfied during reporting period           200,000  
BeiGene Agreement | Milestone Payments              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue from performance obligation expected to be earned     5,000,000.0   5,000,000.0    
Milestone payments earned     0 0 0 0  
BeiGene Agreement | Royalties              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Revenue     0 0 0 0  
Pfizer Agreement              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Termination of contract, period after first commercial sale of product   10 years          
Period required for notice of termination of contract   60 days          
Expenses related to collaboration agreement     $ 0 $ 1,500,000 4,500,000 4,000,000.0  
Pfizer Agreement | Milestone Payments              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Expenses related to collaboration agreement         3,000,000.0 1,000,000.0  
Pfizer Agreement | Research and Development Services              
Research and Development Arrangement, Contract to Perform for Others [Line Items]              
Expenses related to collaboration agreement         $ 1,500,000 $ 3,000,000.0