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Collaboration Agreements - Narrative (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Jan. 07, 2018
Oct. 31, 2014
Mar. 31, 2020
Mar. 31, 2019
Dec. 31, 2018
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Expenses related to collaboration agreement     $ 71,708,000 $ 34,240,000  
BeiGene Agreement          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Up-front fee received $ 10,000,000.0        
Revenue from performance obligation expected to be earned $ 123,000,000.0        
Termination of contract, period after first commercial sale of product 10 years        
Period required for notice of termination of contract 60 days        
Revenue from performance obligations satisfied during reporting period     29,000    
BeiGene Agreement | Licenses of Intellectual Property          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Revenue from performance obligation earned     0 0 $ 9,500,000
BeiGene Agreement | Manufacturing Supply Services          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Revenue from performance obligation earned       1,100,000 $ 500,000
Payments received in advance     (300,000) (1,200,000)  
Revenue from performance obligations satisfied during reporting period       100,000  
Cost-sharing receivable     200,000    
BeiGene Agreement | Milestone Payments          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Revenue from performance obligation expected to be earned     5,000,000.0    
Milestone payments earned     0 0  
BeiGene Agreement | Royalties          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Revenue     0 0  
Pfizer Agreement          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Termination of contract, period after first commercial sale of product   10 years      
Period required for notice of termination of contract   60 days      
Expenses related to collaboration agreement     4,500,000 2,500,000  
Pfizer Agreement | Milestone Payments          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Expenses related to collaboration agreement     3,000,000.0 1,000,000.0  
Pfizer Agreement | Research and Development Services          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Expenses related to collaboration agreement     $ 1,500,000 $ 1,500,000