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Summary of Significant Accounting Policies - Potentially Dilutive Shares (Details) - shares
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Potentially dilutive securities not included in the calculation of diluted net loss per share (in shares) 12,634,061 13,413,024 7,573,251
Common stock options      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Potentially dilutive securities not included in the calculation of diluted net loss per share (in shares) 2,403,055 1,781,388 38,675
Common stock warrants      
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]      
Potentially dilutive securities not included in the calculation of diluted net loss per share (in shares) 10,231,006 11,631,636 7,534,576